1st Edition
Gamma-Hydroxybutyrate Pharmacological and Functional Aspects
272 Pages
by
CRC Press
268 Pages
by
CRC Press
268 Pages
by
CRC Press
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Gamma-hydroxybutyrate (GHB) has come a long way since early experiments in animals where it was found to induce a sleep-like state and from its use in general anaesthesia in human subjects. It has been found to be a naturally-occurring compound in the brain, a metabolite of GABA, the emerging ubiquitous inhibitory neurotransmitter. This has opened up a completely new line of research in an effort... Read more
Metabolism and Distribution of Gamma-Hydroxybutyrate in the Brain. The Gamma-hydroxybutyrate Receptor in the Brain. Part of the Pharmacological Actions of Gamma-hydroxybutyrate Are Mediated by GABAB Receptors. Membrane Transport of Gamma-hydroxybutyrate. Action of Gamma-hydroxybutyrate on Neuronal Excitability and Underlying Membrane Conductances. Regulation of Central Dopamine by Gamma-hydroxybutyrate. Effects of Gamma-hydroxybutyrate on Sleep. Gamma-hydroxybutyrate and Absence Seizure Activity. Behavioral Pharmacology of Gamma-hydroxybutyrate. Therapeutic Uses of Gamma-hydroxybutyrate. Abuse Potential and Toxicology of Gamma-hydroxybutyrate. 4-Hydroxybutyric Aciduria. Gamma-Hydroxybutyrate and Oxidative Stress. The Role of Gamma-hydroxybutyrate in Brain Function.
Biography
Gadfrey Tunnicliff, Christopher D. Cash
