1st Edition

Gene Delivery Systems Development and Applications

Edited By Yashwant V. Pathak Copyright 2022
    316 Pages 23 B/W Illustrations
    by CRC Press

    This unique volume in our Drugs and Pharmaceutical Sciences series covers the development of gene therapy today, the technology involved, clinical applications of siRNA, non-viral vector-based mRNA delivery using nanotechnology, and RNA based vaccines for treating the infectious diseases. It also presents the current application of the CRISPR/Cas9 gene-editing technique which has revolutionized genome editing and which was awarded the 2020 Nobel Prize in Chemistry. Several new drug delivery systems are explored for the applications of gene therapy. These are found to be useful in treating chronic illnesses, including cancer and infectious diseases.

    Key Features:

    • Overview of the development of gene therapy
    • Provides the most up to date information on the development of gene therapy, from the technology involved to gene correction and genome editing
    • Presents CRISPR gene therapy recent trends and applications
    • Discusses siRNA, mRNA, and DNA plasmids


    About the Editor

    List of Contributors

    1. Overview of Development of Gene Therapy

    Ofosua Adi-Dako, Doris Kumadoh, Yashwant V. Pathak and Nana Kwame Gyamerah

    2. Understanding the Technologies Involved in Gene Therapy

    Manish P. Patel, Jayvadan K. Patel, Mukesh Patel and Govind Vyas

    3. Gene Therapy and Gene Correction: Target, Progress and Challenges to Treat Human Diseases

    Manish P. Patel, Sagar A. Popat and Jayvadan K. Patel

    4. Clinical Applications of siRNA

    Seth Kwabena Amponsah, Ismaila Adams and Kwasi Agyei Bugyei

    5. Human Genomics Projects, Gene Therapy and Precision Medicine

    Sakshi Thassu and Yashwant V. Pathak

    6. The Current State of Non-Viral Vector–Based mRNA Medicine Using Various Nanotechnology Applications

    Kshama Patel, Preetam Dasika and Yashwant V. Pathak

    7. RNA-Based Vaccines for Infectious Disease

    Deepa Dehari, Aiswarya Chaudhuri, Sanjay Singh, and Ashish Kumar Agrawal

    8. Conditional Replication of Oncolytic Virus Based on Detection of Oncogenic mRNA

    Rakesh Sharma, Arvind Trivedi and Robert Moffatt

    9. Unilateral Ex Vivo Gene Therapy by GDNF in Neurodegenerative Diseases

    Sonia Barua and Yashwant V. Pathak

    10. Gene Therapy for Cancer Treatment: Recent Trends and Clinical Evidence

    Manish P. Patel, Mansi S. Shah, Mansi N. Athalye and Jayvadan K. Patel

    11. Gene Therapy for Retina and Eye Diseases

    Khushboo Faldu and Jigna Shah

    12. COVID-19 Vaccine Development and Applications

    Kavita Trimal and Kalpana Joshi

    13. In Vivo Gene Therapy: AAV2 Vectors

    Vandit Shah and Jigna Shah

    14. Gene Therapy for Acquired Tissue Damage: Scope, Quality, Non-Clinical and Clinical Guidelines of Gene Therapy Medical Products

    Rakesh Sharma, Robert Moffatt, Yuvraj Singh Negi and Shashi Prabha Singh

    15. iMRI for Clinical Gene Therapy

    Disha Patel, Khushboo Faldu and Jigna Shah



    Dr. Yashwant Pathak completed a PhD in Pharmaceutical Technology at Nagpur University, India and EMBA & MS in Conflict Management from Sullivan University. He is Professor and Associate Dean for Faculty Affairs at College of Pharmacy, University of South Florida. Tampa, Florida. With extensive experience in academia as well as industry, he has more than 100 publications and 2 patent and 2 patent application, 20 edited books published, including 7 books in Nanotechnology and 6 in Nutraceuticals and drug delivery systems. Dr Yashwant Pathak is also a Professor of Global health with College of Public health at USF, and recently his student completed PhD in Global health on Homeopathy medicine and its efficacy, a survey of 1274 patients in Pune in India.