Gene Therapy describes the delivery systems now available to target a given tissue with specific gene or oligonucleotide sequences, and explores the utility of animal modules as test systems. In the context of selected disease states, it summarises in vitro and in vivo studies and clinical trials performed to date.
Table of Contents
Scope and limitations of gene therapy, K. Sikora. Tissue-directed gene delivery systems, C.R. Middaugh et al. Retroviral vectors, W.H. Gunzburg and B. Salmons. Adenovirus vectors, C.J.A. Ring. Adeno-associated virus vectors for human gene therapy, J.S. Bartlett and R.J. Samulski. Liposome delivery systems, R.K. Scheule and S.H. Cheng. Development of mammalian artificial chromosome vectors: prospects for somatic gene transfer, Z. Larin. Infectious herpes vectors for gene therapy, J.-M.H. Vos et al. Role of animal models in gene therapy, J.R. Dorin and D.J. Porteous. Gene targeting as an approach to gene therapy, A. Porter. Cystic fibrosis, N.J. Caplen and E.W.F.W. Alton. Gene therapy for haemophilia B, K. Kurachi and J.-M. Wang. Gene therapy for adenosine deaminase deficiency, H.B. Gaspar and C. Kinnon. Cardiovascular disease, B.A. French. Cancer gene therapy I: genetic intervention strategies, L.-A. Martin and N.R. Lemoine. Cancer gene therapy II: immunomodulation strategies, J. Galea-Lauri and J. Gaken. The muscular dystrophies, C.A. Sewry and T.A. Partridge. Recent developments in gene therapy for neurological disorders, P.R. Lowenstein.
Cooper, David; Lemoine, Prof Nick
'Extremely well written and well documented and gives a balanced view of a complex area of scientific endeavor.' - Genetical Research
'Enjoyable and easy to read good use made of illustrations and tables and excellent and comprehensive review of the major topics associated with gene therapy, and it should become a standard reference for anyone in the field.' - Molecular Medicine Today
'I recommend it to anyone wishing to find out more about gene therapy, whether they are a qualified clinician, basic scientist or student in training.' - Biologist