1st Edition

General and Comparative Endocrinology An Integrative Approach

By A.M. Schreiber Copyright 2024
    677 Pages 300 Color & 191 B/W Illustrations
    by CRC Press

    677 Pages 300 Color & 191 B/W Illustrations
    by CRC Press

    677 Pages 300 Color & 191 B/W Illustrations
    by CRC Press

    General and Comparative Endocrinology: An Integrative Approach, takes a holistic approach to endocrinology, introducing students to the diverse facets of this interdisciplinary science ranging from the medical to comparative domains, while also exploring evolutionary, environmental, and conservation specializations within the field. The textbook is founded on the principle that students interested in the health sciences will benefit from understanding how proficiency in endocrine function among a diversity of organisms contributes to advances in modern medicine. Likewise, students intrigued by comparative physiology will benefit from the wealth of knowledge derived from medical/clinical endocrinology, the historical bedrock of the field. This textbook represents the modern field of endocrinology in its totality by addressing topics and recent advances not currently discussed in other introductory endocrinology textbooks.

    Key Features

    • Introduces the broad and interdisciplinary scope of endocrinology.
    • Provides clear chapter objectives and key concepts.
    • Includes summary and synthesis questions for each chapter that are suitable for exams and quizzes.
    • Includes a chapter devoted to endocrine-disrupting chemicals.
    • Describes the roles played by the endocrine system in important health challenges related to appetite regulation, obesity, diabetes, and other diseases stemming from ‘mismatches to modernity’.
    • Integrates evolutionary and comparative approaches to hormones and health.



    Author Biography

    List of Abbreviations

    Unit Overview Unit I. Introduction to Endocrinology

    1. The Scope and Growth of Endocrinology

    2. Fundamental Features of Endocrine Signaling

    3. Evolution of Endocrine Signaling

    Unit Overview Unit II. Mechanisms of Hormone Action

    4. Hormone Classes and Biosynthesis

    5. Receptors

    6. Receptor Binding Kinetics

    Unit Overview Unit III. Neuroendocrinology

    7. Neurosecretion and Hypothalamic Control of the Pituitary

    8. The Pituitary Gland and Its Hormones

    9. Central Control of Biological Rhythms

    Unit Overview Unit IV. Developmental Endocrinology

    10. Thyroid Hormones. Development and

    11. Insect Molting and Metamorphosis

    12. Calcium/Phosphate Homeostasis, Skeletal Remodeling, and Growth

    Unit Overview Unit V. Stress, Blood Pressure, and Ion Balance

    13. The Multifaceted Adrenal Gland

    14. Adrenal Hormones and the Stress Response

    15. Blood Pressure and Osmoregulation

    Unit Overview Unit VI. Appetite, Digestion, and Metabolism

    16. Digestion

    17. Appetite

    18. Energy Homeostasis

    19. Metabolic Dysregulation and Disruption

    Unit Overview Unit VII. Reproduction

    20. Sexual Determination and Differentiation

    21. Male Reproductive System

    22. Female Reproductive System

    23. The Timing of Puberty and Seasonal Reproduction

    24. Pregnancy, Birth, and Lactation

    Unit Overview Unit VIII. Endocrine-Disrupting Chemicals

    25. EDCs: Assessing the Risk

    Appendix 1. Endocrine-Related Nobel Prizes Awarded in the Last Century

    Appendix 2. Some Examples of Endocrine Breakthroughs Using Non- Mammalian Model Organisms

    Appendix 3. Classical and Modern Concepts in Endocrinology

    Appendix 4. Some Vertebrate and Arthropod Hormones and Their Characteristics

    Appendix 5. Some Diseases Associated with GPCR Dysfunction

    Appendix 6. Some Diseases Associated with Nuclear Receptor Dysfunction and Their Treatments

    Appendix 7. The 48 Known Members of the Human Nuclear Receptor Family Categorized According to Sequence Homology

    Appendix 8. Primary Enzymes of Steroid Hormone Biosynthesis

    Appendix 9. A Summary of Steps in Human Digestion

    Appendix 10. Failures in Contraceptive Function during the First Year of Use

    Appendix 11. Secondary Sexual Characteristics in Females and Males Associated with Puberty

    Appendix 12A. Tanner Stages of Breast and Pubic Hair Development in Females

    Appendix 12B. Tanner Stages of External Genitalia and Pubic Hair Development in Males

    Appendix 13. Classifications of Some Common Endocrine-Disrupting Chemicals




    Alex Schreiber is a comparative endocrinologist at St. Lawrence University where he holds the R. Sheldon ‘68 and Virginia H. Johnson Professorship in the Sciences. He teaches classes in endocrinology, cell biology, and physiology. His research addresses vertebrate metamorphosis, focusing on the influences of thyroid hormones and glucocorticoid stress hormones on amphibian development. He received a B.A. in biology from the University of Colorado, Boulder. After serving in the U.S. Peace Corps in Kenya, he went on to earn an M.S. in biology from Eastern Washington University studying the osmoregulatory physiology of migrating salmon under the tutelage of Dr. Ronald J. White. He then earned a PhD in zoology at the University of Rhode Island studying the endocrinology of flatfish metamorphosis with Dr. Jennifer Specker. He pursued postdoctoral research at the Carnegie Institution’s Department of Embryology, studying the molecular biology of amphibian metamorphosis in Dr. Donald Brown’s laboratory. His summers are spent in East Africa where he teaches classes in wildlife biology and high altitude physiology.