This book describes the identification and characterization of genetic loci that determine susceptibility to liver, mammary, or skin carcinogenesis in rodents. It focuses on protein kinases and phospholipases, and stress-related signal transduction.
Part I: Genetic Variants for Responses to Carcinogens, Tumor Promoters, and Growth Factors 1. Genetic Control of Hepatocarcinogenesis in Inbred Mice 2. Modulation of Mammary Carcinogenesis by Enhancer and Suppressor Genes 3. Genetic Determinants of Susceptibility to Mouse Skin Tumor Promotion in Inbred Mice 4. Suppression and Expression of the Transformed Phenotype in Two-Stage C3H10T1/2 Transformants 5. Genetic Analysis of Transformation by the src Oncogene 6. Transduction of Mitogenic Signals in Normal and Malignant Cells Impaired in Na+ :H+ Antiport-Mediated pH Regulation Part II: Genes That Confer Susceptibility to Neoplastic Transformation 7. Genes and Signals Involved in Tumor Promoter-Induced Transformation 8. Regulation of Gene Expression by the Tumor Promoter 12-0-Tetr adecanoylphorbol-13 -Acetate 9. Gene Activation During Multistage Carcinogenesis in Mouse Skin 10. Tumor Promotion by 2,3,7,8-Tetrachlorodibenzo-p-dioxin 11. Genes That Confer Susceptibility to Neoplastic Transformation on Rat Fibroblasts 12. Regulation of Human Papillomavirus Gene Expression Part III: Signal Transduction: Protein Kinases and Phospholipases 13. Protein Kinase C: Structural Definition 14. Role of Protein Kinase C in Stimulation of Interleukin 2 Production 15. Lipocortins, a Family of Phospholipase A2-Inhibitory Proteins 16. Role of rafand myc Oncogenes in Signal Transduction Part IV: Stress-Associated Signals and Gene Regulation 17. fos and the Immediate-Early Response in the Central Nervous System 18. Free Radicals and Signal Transduction in Tumor Promotion 19. cis- and trans-Acting Genetic Elements Responsible for Induction of Specific Genes by Tumor Promoters, Serum Factors, and Stress 20. Structure Function Analysis of fos Protein