1st Edition
Genetic Polymorphism and Disease
Genetic polymorphisms are important determinants of phenotypic variations and may modulate the risk to or even cause various diseases including genetic disorders and multifactorial diseases. Genetic polymorphisms also serve as important genetic, population and evolutionary markers that allow the study of genetic and evolutionary aspects of individuals, populations and organisms and aid in tracing the evolutionary and parental lineages. Genetic polymorphisms in low penetrance genes are responsible for the alterations in the gene expression of critical signal transduction proteins and metabolic enzymes. Some of these polymorphisms are linked to increased susceptibility to various diseases especially cancers, cardiovascular diseases, immune disorders, neurological pathologies. This book collates the reviews on the roles played by polymorphisms in critical metabolic, signal transduction, cell cycle or DNA repair genes either directly or indirectly in the disease mechanisms. The focus is on various techniques for identifying the various Single Nucleotide Polymorphisms (SNPs). Polymorphism studies document the affect SNPs, and their expressions have upon the functionality of the enzymes, proteins.
Key Features
- Describes the genetic polymorphism and its various types
- Discusses the role of genetic polymorphisms in modulating the risk of various human diseases
- Explores various molecular techniques used for detecting GPs
- Characterizes the role of SNPs in modulating the susceptibility of human diseases
- Provides a genetic basis for individual variations in response to therapeutics
Chapter 1 - Genetic Polymorphisms - Classification, Structure, Detection and Function
Mujeeb Zafar Banday
Aga Syed Sameer
Saniya Nissar
Chapter 2 - Clinical relevance of Pharmacogenomics a road to personalized medicine
Nusrath Yasmeen
Shobana John
Vikram Kumar
Moudi M Alasmari
Chapter 3 - Diabetes and Role of SNPs in diabetes susceptibility
Johra Khan
Sayequa Dandoti
Chapter 4 - Genetic polymorphism associated with innate immune response to Malaria
Amre Nasr
Amir Abushouk
Chapter 5 - Xenobiotic Metabolic Enzyme Polymorphisms and cancer susceptibility
Saniya Nissar
Aga Syed Sameer
Mujeeb Zafar Banday
Fouzia Rashid
Chapter 6 - Genetic Polymorphisms in Matrix Metallo-Proteinase (MMP) Genes and Cancer
Mujeeb Zafar Banday
Saniya Nissar
Aga Syed Sameer
Ehtishamul Haq
Sabhiya Majid
Chapter 7 - Vitamin D receptor polymorphisms and diseases
Aga Syed Sameer
Mujeeb Zafar Banday
Saniya Nissar
Mansour AlQurashi
Abdullah Awadh
Alqassem Hakami
Israa A Malli
Chapter 8 - Genetic Polymorphism in Fatty Acid Metabolism Genes and Cancer Susceptibility
Mosin S Khan
Sunia Faiz
Iqra Farooq
Suhail S Lone
Sabhiya Majid
Waseem Qureshi
Chapter 9 - Single nucleotide polymorphisms (SNPs) and Parkinson's disease
Saniya Nissar
Aga Syed Sameer
Mujeeb Zafar Banday
Sabhiya Majid
Chapter 10 - Genetic Polymorphisms, role in drug metabolism and effect on Clinical Pharmacy
Muneeb U Rehman
Shagufta Sheikh
Sanjeev Rana
Hilal A Wani
Aarif Ali
Qazi Danish
Sabhiya Majid
Nisar A Naikoo
Nouroz Sehar
Amjad Faihan Binlebdah
Azher Arafah
Chapter 11 - Role of genetic polymorphisms om Chronic Inflammatory disease
Saniya Nissar
Aga Syed Sameer
Mujeeb Zafar Banday
Roohi Rasool
Chapter 12 - Single nucleotide polymorphism related computational-resources part I: Databases
Nadiem Nazir Bhat
Showkat Ahmad Dar
Manmeet Kaur
Pallawi Kumari
Chapter 13 - Single nucleotide polymorphism related computational-resources part II: Algorithms
Nadiem Nazir Bhat
Showkat Ahmad Dar
Manmeet Kaur
Pallawi Kumari
Chapter 14 - Role of single nucleotide polymorphisms (SNPs) in common migraine
Aga Syed Sameer
Saniya Nissar
Mujeeb Zafar Banday
Kulsum Akhtar
Razaz Felemban
Moudi M Alasmari
Faheem Hyder Potto
Sheikh A Saeed
Chapter 15 - The Role of Vitamin D Single Nuclear Polymorphisms in Cancer Susceptibility
Abdullah A. Awadh
Chapter 16 - Genetic polymorphisms in fatty acid metabolism genes and cancer susceptibility
Racha Kerek
Chapter 17 - Toll-Like Receptor (TLR) Polymorphisms in Prostate Cancer
Payam BEHZADI
Chapter 18 - Role of Single Nucleotide Polymorphism of Cytochrome P450 Genes in Cancer Susceptibility
Faheem Hyder Pottoo
Sachin Kuma
Rajiv Kumar Tonk
Chapter 19 - Role of Single Nucleotide Polymorphisms of Inflammatory molecules in susceptibility to Cardiovascular diseases (CVDs)
Saniya Nissar
Vishal Kumar Deb
Ahmad Rabbani
Sabhiya Majid
Amir Abushouk
Johra Khan
Bader H Khawaji
Ruqaya Aziz
Mujeeb Zafar Banday
Yasmeen Nusrath
Chapter 20 - Role of Single Nucleotide Polymorphisms of Inflammatory molecules in susceptibility to Cardiovascular diseases (CVDs)
Syed Mudassar
Kulsum Akhtar
Ishrat Parveiz Bhat
Chapter 21 - Cytokine polymorphism and their role in modulating cancer risk
Mosin S Khan
Iqra Farooq
Sunia Faiz
Suhail S Lone
Sabhiya Majid
Waseem Qureshi
Chapter 22 - Gastric Cancer and genetic polymorphism in modulating the susceptibility
Muneeb U Rehman
Shagufta Sheikh
Sanjeev Rana
Hilal A Wani
Aarif Ali
Nouroz Sehar
Sabhiya Majid
Nisar A Naikoo
Bashayr M. Alsuwayni
Azher Arafah
Chapter 23 - Cytokine Gene Polymorphisms & their Role in Autoimmune Diseases
Syed Mudassar
Kulsum Akhtar
Ishrat Parveiz Bhat
Aga Syed Sameer
Syed Douhath Yousuf
Chapter 24 - Genomic disturbances associated with penile cancer and novel therapies
Herney Andrés García-Perdomo
María Juliana Chaves-Medina
Chapter 25 - Role of Genetic Polymorphisms in Gastric Cancer Susceptibility
Syed Mudassar
Syed Douhath Yousuf
Biography
Dr. Syed Sameer Aga is currently working as an Assistant Professor of Biochemistry in the Department of Basic Medical Sciences, College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia. He is also serving as the Chairman of the Quality Assurance Unit in College of Medicine, KSAU-HS. Dr. Syed is a life-time member of many societies related to genetics, molecular biology and medical education like the Royal Society of Biology, Biochemical Society, Association of Clinical Biochemists of India, Society of Indian Academy of Medical Genetics, Middle East Molecular Biology Sources, Asian Council of Science Editors, and Saudi Society of Medical Education, etc. He is also serving as the Associate Editor in five Journals, Frontiers in Oncology – Molecular Biosciences section, BioMed Research International, Education Research International, World Journal of Biological Chemistry and Current Drug Metabolism. He also serves as a full time reviewer for various journals including European Journal of Cancer Prevention (Lippincott Williams & Wilkins), PLOS One & PLOS Genetics (Public Library of Science), World Journal of Gastroenterology (Baishideng Publishing), BMC Medical Genetics (BMC-Springer), Gene & Meta Gene (Elsevier Publishing), Bioscience Reports (Portland Press), Journal of Clinical Laboratory Analysis (John Wiley & Sons) and Tumor Biology (Sage Journals) etc. His research interests are focused on cancer biology and he has published more than ninety research and review articles in high repute journals with an h-index of 22 and authored ten books.
Dr. Mujeeb Zafar Banday is presently working as a Senior Researcher and Lecturer in the Department of Biochemistry, Govt. Medical College, Srinagar. Dr. Banday has completed his Ph.D., M.Phil. and M.Sc. in Biochemistry from the University of Kashmir, J&K, India. He is serving as the review editor and associate reviewer for the journal, Frontiers in Oncology - Cancer Epidemiology and Prevention (Frontiers Group) and full time reviewer for various journals including Gene (Elsevier Publishing), Bioscience Reports (Portland Press), BioMed Research International (Hindawi Publishing) and Toxicology and Environmental Health Sciences Review (Springer Nature). He has authored more than twenty research and review articles and three books.
Dr. Saniya Nissar is presently working as a Senior Researcher and Lecturer in the Department of Biochemistry, Govt. Medical College, Srinagar. She has completed her PhD, MPhil, and MSc in clinical biochemistry from the University of Kashmir, J&K, India. She works as free-lance scientific content writer with many scientific magazines. She has published more than thirty research and review articles and authored four books.
This book will be useful to researchers interested in one of the diseases described and those who are new to studying the relationship between a particular disease and inherited variation...[and] is a welcome addition to the currently available literature."
- Mark F. Sanders, PhD (UC Davis College of Biological Sciences)
