Genetic Toxicology and Cancer Risk Assessment: 1st Edition (Hardback) book cover

Genetic Toxicology and Cancer Risk Assessment

1st Edition

By Wai Nang Choy

CRC Press

406 pages

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Hardback: 9780824702946
pub: 2001-08-31
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pub: 2001-08-31
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Description

Presents state-of-the-art regulatory cancer risk assessment models including a biologically based model for two-hit carcinogenesis and cell proliferation!

This book comprehensively reviews the various roles of genetic toxicology in human cancer risk assessment conducted by United States and worldwide regulatory agencies-discussing hazard identification, dose-response relationships, exposure assessment, and current practices of risk characterization.

Examines predictive values of mutagenicity tests, mechanisms of carcinogenesis, and conventional genotoxicity tests required by the International Conference on Harmonization and the Organization for Economic Cooperation and Development/Environmental Protection Agency guidelines!

Comprised of contributions from prominent experts and risk assessors and including nearly 1200 references to facilitate further study, Genetic Toxicology and Cancer Risk Assessment

  • reviews contemporary human cancer genetics as related to the mutagenic nature of carcinogenesis

  • calculates acceptable exposure levels based on a carcinogenic threshold dose for nongenotoxic carcinogens

  • reveals the rationale and methodology of quantitative estimation of human cancer risks using mathematical models

  • discusses the threshold concept of carcinogenesis

  • demonstrates how bacterial mutagenicity assays are the most reliable for predicting rodent carcinogens

  • considers structural activity relationship (SAR) analysis of chemical carcinogenicity

  • describes the emergence of the mouse lymphoma microwell and in vitro micronucleus assays

  • illustrates the use of genetic biomarkers for dosimetry analysis

  • and more!

    Linking human cancer genetics, mutagenicity assays, mechanisms of carcinogenesis, carcinogenic thresholds, molecular epidemiology, mathematical modeling, and quantitative cancer risk analysis, Genetic Toxicology and Cancer Risk Assessment is a must-have reference for toxicologists; oncologists; geneticists; biostatisticians; reproductive, developmental, cell, and molecular biologists; endocrinologists; biochemists; and upper-level undergraduate, graduate, and medical school students in these disciplines.

  • Reviews

    "

    …engaging and informative….

    …a useful contribution to the field of genetic toxicology.

    "-Doody

    "…well-detailed….

    …a great reference material.

    "-Australian Journal of Medical Science

    "…offers the reader an authoritative, practical insight.

    "-Cancer Forum

    Table of Contents

    Human Cancer Genetics

    Jason W. Barlow and David Malkin

    Genetic Toxicity Tests for Predicting Carcinogenicity

    Errol Zeiger

    Genotoxic and Nongenotoxic Mechanisms of Carcinogenesis

    Wai Nang Choy

    Structure-Activity Relationship (SAR) and its Roles in Cancer Risk Assessment

    David Y. Lai and Yin-tak Woo

    Regulatory Genetic Toxicology Tests

    Wai Nang Choy

    Complementary Genetic Toxicology Assays

    B. Bhaskar Gollapudi

    The Mouse Lymphoma Assay (MLA) Using the Microwell Method

    Masamitsu Honma and Toshio Sofuni

    The In Vitro Micronucleus Assay

    Marilyn J. Aardema and Micheline Kirsch-Volders

    ICH Guidelines on Genotoxicity and Carcinogenicity: Scientific Background and Regulatory Practice

    Lutz Müller, Peter Kasper, and Leonard Schechtman

    New OECD Genetic Toxicology Guidelines and Interpretation of Results

    Michael C. Cimino

    Dose-Response Relationships in Chemical Carcinogenesis and Cancer Risk Assessment

    Werner K. Lutz

    Molecular Epidemiology and Biomarkers

    Jia-Sheng Wang, Jonathan M. Links, John Groopman

    Quantitative Cancer Risk Assessment of Nongenotoxic Carcinogens

    Anna M. Fan and Robert A. Howd

    Risk Assessment of Genotoxic Carcinogens

    Lauren Zeise

    Biologically Based Cancer Risk Assessment Models

    Suresh H. Moolgavkar

    Subject Categories

    BISAC Subject Codes/Headings:
    MED062000
    MEDICAL / Oncology
    MED096000
    MEDICAL / Toxicology