Apoptosis is an essential process in embryonic development and tissue homeostasis, particularly in the prevention of disease. Written from a genetic viewpoint, Genetics of Apoptosis first describes the molecular and cell biology of apoptosis, then examines the process in more detail in several model systems. This volume brings together contributions from internationally renowned authors, and will be a valuable reference to all researchers studying apoptosis.
SECTION I: MOLECULAR BIOLOGY OF APOPTOSIS. Ch 1. Death receptors in apoptosis, R. Ravi and A. Bedi both at The Johns Hopkins University School of Medicine, Baltimore, USA. Ch 2. The role of caspases in apoptosis, S. Kumar and D. Cakouros, both at Hanson Centre for Cancer Research, Adelaide, Australia.Ch 3. Making sense of the Bcl-2 family of apoptosis regulators, L. Haughn and D. Hockenbery both at Fred Hutchinson Cancer Research Center, Seattle, USA. Ch 4. Functional domains in apoptosis proteins, K. Hofmann, Memorec Stoffel GmbH, Cologne, Germany. SECTION II: CELL BIOLOGY OF APOPTOSIS.Ch 5. The role of the endoplasmic reticulum in apoptosis, D.G. Breckenridge and G. C. Shore both at McGill University, Montreal, Canada. Ch 6. Mitochondria in apoptosis induction, B. Antonsson Serono Pharmaceutical Research Institute, Geneva, Switzerland.SECTION III: CELL DEATH IN MODEL SYSTEMS. Ch 7. Regulators and applications of yeast apoptosis, K-U. Fröhlich IMBM, Graz, Austria and Frank Madeo, Universität Tubingen, Germany.Ch 8. Evolution of cell death: caspase mediated mechanisms in early metazoans. non-caspase mechanisms in single- celled eukaryotes, A. Böttger and C. David, University of Munich, Germany.Ch 9. Programme cell death in C. Elegans, A. Gartner, A. Alpi and B. Schumacher all at Max-Planck-Institute for Biochemistry, Martinsried, Germany. Ch 10. Apoptosis in Drosophilia, K. White Massachusetts General Hospital, Charlestown, USA. Ch 11. Cell culture systems in apoptosis, S. Grimm Max-Planck-Institute for Biochemistry, Martinsried, Germany. Ch 12. Caspase-independent cell death, M. Leist and Marja Jäättela H. Lundbeck A/S, Copenhagen-Valby, Copenhagen, Denmark and Denmark Institute for Cancer Biology, Copenhagen, Denmark.