Genome Stability: DNA Repair and Recombination, 1st Edition (Paperback) book cover

Genome Stability

DNA Repair and Recombination, 1st Edition

By James Haber

Garland Science

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Paperback: 9780815344858
pub: 2013-12-16
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Description

Genome Stability: DNA Repair and Recombination describes the various mechanisms of repairing DNA damage by recombination, most notably the repair of chromosomal breaks. The text presents a definitive history of the evolution of molecular models of DNA repair, emphasizing current research. The book introduces the central players in recombination. An overview of the four major pathways of homologous recombinational repair is followed by a description of the several mechanisms of nonhomologous end-joining. Designed as a textbook for advanced undergraduate and graduate students with a molecular biology and genetics background, researchers and practitioners, especially in cancer biology, will also appreciate the book as a reference.

Table of Contents

Chapter 1: Restarting DNA Replication by Recombination

Chapter 2. Double-strand Break Repair Pathways

Chapter 3: RecA/Rad51 and the Search for Homology

Chapter 4. Preparation of the RecA/Rad51 Filament

Chapter 5. Single-Strand Annealing

Chapter 6. Gene Conversion

Chapter 7. In vivo Biochemistry: Recombination in Yeast

Chapter 8: Break-induced Replication

Chapter 9: Sister Chromatid Repair

Chapter 10. Gene Targeting

Chapter 11. Site-specific Recombination

Chapter 12. Cytology and Genetics of Meiosis

Chapter 13. Molecular Events During Meiotic Recombination

Chapter 14 Holliday Junction Resolvases and Crossing-over

Chapter 15. Nonhomologous End-joining

Chapter 16. DNA Damage Checkpoints and Genome Instability

About the Author

James Haber is at Brandeis University, Biology Deptartment, USA.

Subject Categories

BISAC Subject Codes/Headings:
SCI017000
SCIENCE / Life Sciences / Cytology
SCI029000
SCIENCE / Life Sciences / Genetics & Genomics
SCI049000
SCIENCE / Life Sciences / Biology / Molecular Biology
SCI086000
SCIENCE / Life Sciences / General