1st Edition

Genomics Data Analysis False Discovery Rates and Empirical Bayes Methods

By David R. Bickel Copyright 2020
140 Pages 10 B/W Illustrations
by Chapman & Hall

140 Pages 10 B/W Illustrations
by Chapman & Hall

140 Pages 10 B/W Illustrations
by Chapman & Hall

Statisticians have met the need to test hundreds or thousands of genomics hypotheses simultaneously with novel empirical Bayes methods that combine advantages of traditional Bayesian and frequentist statistics. Techniques for estimating the local false discovery rate assign probabilities of differential gene expression, genetic association, etc. without requiring subjective prior distributions.... Read more

1.Basic probability and statistics, 2. Introduction to likelihood, 3. False discovery rates, 4. Simulating and analyzing gene expression data, 5. Variations in dimension and data, 6. Correcting bias in estimates of the false discovery rate, 7. The L value: An estimated local false discovery rate to replace a p value, 8. Maximum likelihood and applications, Appendix A. Generalized Bonferroni correction derived from conditional compatibility, Appendix B. How to choose a method of hypothesis testing.

Biography

David R. Bickel is an Associate Professor in the Department of Biochemistry, Microbiology and Immunology of the University of Ottawa and a Core Member of the Ottawa Institute of Systems Biology. Since 2011, he has been teaching classes focused on the statistical analysis of genomics data. While working as a biostatistician in academia and industry, he has published new statistical methods for analyzing genomics data in leading statistics and bioinformatics journals. He is also investigating the foundations of statistical inference. For recent activity, see davidbickel.com or follow him at @DavidRBickel (Twitter).