Geometric Induction of Bone Formation  book cover
1st Edition

Geometric Induction of Bone Formation

  • Available for pre-order. Item will ship after December 30, 2020
ISBN 9780367195786
December 30, 2020 Forthcoming by CRC Press
264 Pages 93 Color Illustrations

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Book Description

This novel book describes new biomaterials that offer mechanistic osteogenic surfaces for rapid autonomous bone repair and generation. The chapters frame our understanding of regenerative medicine in primate species, including humans. The goal is to unravel the fundamental biological mechanisms of bone formation and repair unique humans. The target audience is broad and dovetails with several disciplines both in the academic and private biotech sectors primarily involved in molecular biology, tissue biology, tissue engineering, biomaterial science, reconstructive surgery, orthopedic, plastic and dental surgery.

Table of Contents

When and Why Bone Forms and Sometime Repair and Regenerate:

The Enigmatic Myth and the Dream of Regenerative Medicine.

The Osteogenic Proteins of the Transforming Growth Factor-β (TGF-β) Supergene Family: Pleiotropism and Redundancy.

Functionalized surfaces Beyond Morphogens and Stem Cells.

Geometric Cues, Concavity and Induction.

Coral-Derived and Sintered Macroporous Constructs Initiate Spontaneous Induction in Heterotopic Extraskeletal Sites: Morphological Time Studies.

Molecular Pathways Regulating Induction: Sintering and Embedding Osteogenic Proteins by Nanotopographic Geometric


The Spontaneous Induction by an Intrinsically Osteoinductive Bioreactor for Human patients: Osteoinductive

Hydroxyapatite-Coated Titanium Implants.

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Ugo Ripamonti is a leader in the field of tissue induction and differentiation in postnatal osteogenesis. His principal achievement is the demonstration of the induction of bone formation in non-human primate models. In 1994 he was appointed professor at the Medical School University of the Witwatersrand in South Africa, leading its newly founded Bone Research Laboratory. He has written more than 200 publications, given more than 120 invited lectures at international symposia, and organized a series of workshops and symposia at the World Biomaterials Congresses and the International Conferences on Bone Morphogenetic Proteins.