Green Synthesis in Nanomedicine and Human Health  book cover
1st Edition

Green Synthesis in Nanomedicine and Human Health

ISBN 9780367710811
Published March 10, 2021 by CRC Press
342 Pages

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Book Description

Green synthesis is an emerging method for deriving nanoparticles present in natural plants for use in nanomedicine. Written by experts in the field, Green Synthesis in Nanomedicine and Human Health showcases the exciting developments of this specialty and its potential for promoting human health and well-being.

This book gives practical information on novel preparation methods for identifying nanoparticles present in natural plants. It discusses applications of nanoparticles in combating communicable, non-communicable and vector-borne diseases. It also explores the potential for nanoparticles to combat antimicrobial resistance through improvements in treatment methods, diagnostics and drug delivery systems.

  • Features scientific evidence of opportunities for integrating indigenous flora into nanomedicine to develop cost-effective therapeutic and diagnostic solutions for diseases, including cancer, tuberculosis, malaria and diabetes.
  • Places green synthesis and nanomedicine in the African orthodox and traditional healthcare context.
  • Provides policymakers with scientific evidence to inform policies for controlling or mitigating dangerous diseases.

This book is essential reading for students, scientists, policymakers and practitioners of nanotechnology, and will appeal to anyone with an interest in integrating traditional African healthcare and Western medicine.

Table of Contents

SECTION I Green Synthesis of

Nanoparticles from Natural Plant Parts

General Overview

[Maluta Steven Mufamadi, Rofhiwa Mulaudzi, Richard L.K.

Glover and Daniel Nyanganyura]

SECTION II Nanotechnology for

Treatment of Non-Communicable Diseases

Chapter 1 Cancer Nanotheranostics: Next-Generation Early Detection and

Treatment Prioritization for Cancers Using Phytonanotechnology

[Maluta Steven Mufamadi, Marian Jiya John,

Mpho Phehello Ngoepe and Palesa Rose Sekhejane]

Chapter 2 Green Synthesis of Nanoparticles Using Plant Extracts: A

Promising Antidiabetic Agent

[Rofhiwa Bridget Mulaudzi,

Mahwahwatse Johanna Bapela and Thilivhali Emmanuel


Chapter 3 Green Nanoparticles: An Alternative Therapy for Oral


[Razia Z. Adam, Enas Ismail, Fanelwa Ajayi, Widadh Klein,

Germana Lyimo and Ahmed A. Hussein]

SECTION III Nanotechnology for

Treatment of Communicable Diseases

Chapter 4 Nanotechnology and Nanomedicine to Combat Ebola Virus


[Maluta Steven Mufamadi]

Chapter 5 Application of Next-Generation Plant-Derived

Nanobiofabricated Drugs for the Management of Tuberculosis

[Charles Oluwaseun Adetunji, Olugbenga Samuel Michael,

Muhammad Akram, Kadiri Oseni, Ajayi Kolawole Temidayo,

Osikemekha Anthony Anani, Akinola Samson Olayinka,

Olerimi Samson E, Wilson Nwankwo, Iram Ghaffar and

Juliana Bunmi Adetunji]

SECTION IV Nanotechnology for

Treatment of Vector-Borne Diseases

Chapter 6 Biogenic Nanoparticles Based Drugs Derived from Medicinal

Plants: A Sustainable Panacea for the Treatment of Malaria

[Charles Oluwaseun Adetunji, Olugbenga Samuel Michael,

Wilson Nwankwo, Osikemekha Anthony Anani, Juliana Bunmi

Adetunji, Akinola Samson Olayinka and Muhammad Akram]

SECTION V Nanotechnology in

Combating Antimicrobial Resistance

Chapter 7 Bioengineering of Inorganic Nanoparticle Using Plant Materials

to Fight Extensively Drug-Resistant Tuberculosis

[Mpho Phehello Ngoepe and Maluta Steven Mufamadi]

Chapter 8 Recent Advances in the Utilization of Bioengineered Plant-

Based Nanoparticles: A Sustainable Nanobiotechnology for the

Management of Extensively Drug-Resistant Tuberculosis

[Charles Oluwaseun Adetunji, Olugbenga Samuel Michael,

Muhammad Akram, Kadiri Oseni, Olerimi Samson E,

Osikemekha Anthony Anani, Wilson Nwankwo, Hina Anwar,

Juliana Bunmi Adetunji, and Akinola Samson Olayinka]

Chapter 9 Green Synthesis of Nanoparticles and Their Antimicrobial

Efficacy against Drug-Resistant Staphylococcus aureus

[Nonhlanhla Tlotleng, Jiya M. John,

Dumisile W. Nyembe and Wells Utembe]

Chapter 10 Green Metal-Based Nanoparticles Synthesized Using Medicinal

Plants and Plant Phytochemicals against Multidrug-Resistant

Staphylococcus aureus

[Abeer Ahmed Qaed Ahmed, Lin Xiao,

Tracey Jill Morton McKay and Guang Yang]

SECTION VI Cross-Cutting Issues

Chapter 11 Polymer-Based Protein Delivery Systems for Loco-Regional


[Muhammad Haji Mansor, Emmanuel Garcion, Bathabile

Ramalapa, Nela Buchtova, Clement Toullec, Marique Aucamp,

Jean Le Bideau, Francois Hindre, Admire Dube, Carmen

Alvarez-Lorenzo, Moreno Galleni, Christine Jerome, and

Frank Boury]

Chapter 12 Nanomedicines for the Treatment of Infectious Diseases:

Formulation, Delivery and Commercialization Aspects

[Admire Dube, Boitumelo Semete-Makokotlela,

Bathabile Ramalapa, Jessica Reynolds and Frank Boury]

Chapter 13 Green-Synthesized Nanoparticles as Potential Sensors for

Health Hazardous Compounds

[Rachel Fanelwa Ajayi, Sphamandla Nqunqa, Yonela Mgwili,

Siphokazi Tshoko, Nokwanda Ngema, Germana Lyimo,

Tessia Rakgotho, Ndzumbululo Ndou,and Razia Adam]

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Dr Steven Mufamadi is the founder and managing director of Nabio Consulting (Pty) Ltd. He has earned his PhD in (nano)pharmaceutics from Wits University, entrepreneurship short courses from University of Pretoria and Ecole Polytechique Federale de Lausanne (EPFL), Switzerland. His interest is in the health applications of nanotechnology, entrepreneurship and commercialization. He has authored and co-authored three patents, one of which is an international patent, several peer-reviewed scientific publications and book chapters. He was awarded the awards an international inventor by the Wits enterprise & Wits University Innovation Forum, and the best peer reviewed research paper of pharmaceutics (nanomedicine) by South African Academy of Pharmaceutical Sciences. In 2017, he was supported for UNESCO-Kalinga Prize for the popularization of nanotechnology in South Africa by the South African National Commission for UNESCO. From 2014, he is member of the national nanotechnologies committee (ISO TC229) at the South African Bureau of Standards (SABS).

Dr Rofhiwa Bridget Mulaudzi holds a PhD degree in Ethnobotany and MSc in Botany from the University of KwaZulu-Natal. She holds an Honours degree in Biochemistry and BSc degree in Biochemistry and Microbiology from the University of Venda and  is registered with the South African Council for Natural Scientific Professions (SACNASP) as a Professional Natural Scientist. Apart from university degrees, Rofhiwa completed a formal certificate courses  in Basic, Intermediate and Advanced Project Management at University of South Africa and a Certificate in Bio-Entrepreneurship Training Programme at Coach Lab, the Innovation Hub, Pretoria, South Africa. Dr Mulaudzi was a Researcher in Medicinal Plants at the Agricultural Research Council. Her current research projects are focusing on the Research and Development (R&D) of both medicinal plants and indigenous vegetables as medicine for human health and wellbeing. Dr Mulaudzi has published 14 peer reviewed articles in international journals and contributed chapters to books. Her current research interests include development of nanomedicine drugs using African indigenous plants and using African leafy vegetables as source of medicine. She is currently a Researcher/Consultant in natural plants/products at Romukhu (Pty) Ltd, and COO at Anwa Laboratories (Pty) Ltd under the Pecolo Group.

Dr Richard Lander Kwame Glover (Pr. Nat. Sci.) is a Biological Scientist with a bias in Food Microbiology. Dr Glover worked as a Research Officer at the Centre for Scientific Research into Plant Medicine at Mampong-Akwapim in Ghana from 1991 to 1996 where he set up its  Microbiological Screening Laboratory for validation of herbal and traditional medicinal products. He joined the Department of Applied Biology, Faculty of Applied Sciences of the University for Development Studies (UDS), Navrongo Campus as a lecturer/researcher in Microbiology in 1996. He served as Head  of Department and  was a Senior Lecturer when he  left UDS in 2012. Dr Glover also led  DANIDA-sponsored projects on Capability Building for Research in Traditional Fermented Food Processing in West Africa. Dr Glover currently works as Programme Specialist (Biological Sciences) with  the International Science Council [ISC] Regional Office for Africa (formerly International Council for Science-[ICSU] Regional Office for Africa), Pretoria, South Africa. Dr Glover has participated in several international training programmes  and conferences. He has over  twenty peer-reviewed journal publications as well as several conference proceedings to his credit. He is the Regional Programme Officer (RPO) and member of the Steering Committee of the International Network for Government Science Advice (INGSA) Africa Chapter. He is a member of the South African Council for Natural Scientific Professions (SACNASP) with Registration Number 115865. 


Dr Daniel Nyanganyura is the current Regional Director for the International Science Council for Science (ISC) Regional Office for Africa (ROA) since February 2017 and acted in this position from June 2016 to January 2017. He holds a PhD in Atmospheric Physics (2007), an MSc in Agricultural Meteorology (1999), and a BSc 4th Year Honour in Physics (1997) from the University of Zimbabwe; and a Licentiate Degree in Education in the Specialty of Physics and Astronomy from Enrique José Varona Higher Pedagogical Institute, Havana, Cuba (1991). He was Programme Specialist for Physics, Mathematics and Engineering Sciences at the International Council for Science Regional Office for Africa (2008 – 2016); an air pollution research scientist at the Max Planck Institute for Chemistry in Mainz, Germany (August 2007 - July 2008); a Physics lecturer at the University of Zimbabwe (2000 - 2007); an A-Level Physics and Computer Science Teacher (1991 - 1998). At ISC ROA, he manages and oversees ISC scientific programmes/activities in Africa. He is a member of the South African Institute of Physics; South African Society for Atmospheric Sciences; European Geophysical Union; the Air Pollution Information Network for Africa; and International Society for Agricultural Meteorology.