2nd Edition

Handbook for Critical Cleaning Applications, Processes, and Controls, Second Edition

Edited By Barbara Kanegsberg, Ed Kanegsberg Copyright 2011
    574 Pages 140 B/W Illustrations
    by CRC Press

    574 Pages 140 B/W Illustrations
    by CRC Press

    Applications, Processes, and Controls is the second volume in the Handbook for Critical Cleaning, Second Edition.

    Should you clean your product during manufacturing? If so, when and how? Cleaning is essential for proper performance, optimal quality, and increased sales. Inadequate cleaning of product elements can lead to catastrophic failure of the entire system and serious hazards to individuals and the general public.

    Gain a competitive edge with proven cleaning and contamination-control strategies

    A decade after the bestselling original, the Handbook for Critical Cleaning, Second Edition helps manufacturers meet today’s challenges, providing practical information and perspective about cleaning chemistries, equipment, processes, and applications. With 90% new or revised chapters plus supplementary online material, the handbook has grown into two comprehensive volumes: Cleaning Agents and Systems, and Applications, Processes, and Controls.

    Helping manufacturers become more efficient and productive, these books:

    • Show how to increase profitability and meet both existing and expected product demand
    • Clarify the sea of print and Internet information about cleaning chemistries and techniques
    • Address challenges of performance, miniaturization, and cost, as well as regulatory and supply chain pressures
    • Offer clearly written guidance from the viewpoints of more than 70 leading industry contributors in technical, management, academic, and regulatory disciplines

    Overview chapters by the editors, industry icons Barbara and Ed Kanegsberg, meld the different viewpoints and compile and critique the options. The result is a complete, cohesive, balanced perspective that helps manufacturers better select, implement, and maintain a quality, value-added cleaning process.

    The second volume, Handbook for Critical Cleaning: Applications, Processes, and Controls, addresses how to implement, validate, monitor, and maintain a critical cleaning process. Topics include cleanrooms, materials compatibility, worker safety, sustainability, and environmental constraints. The book shows readers how to draw from diverse disciplines—including aerospace, art conservation, electronics, food, life sciences, military, optics, and semiconductors—to achieve superior productivity.

    Part I: Process Implementation and Control

    Evaluating, Choosing, and Implementing the Process: How to Get Vendors to Work with You, B. Kanegsberg

    Cleaning Agent Balancing Act, B. Kanegsberg

    Blunders, Disasters, Horror Stories, and Mistakes You Can Avoid, A. Gillman

    Cleaning Practices and Pollution Prevention, M.S. Callahan

    Basis of Design for Life Science Cleanroom Facilities, S.E. Mackler

    Validating and Monitoring the Cleanroom, K. O’Donoghue

    Cleanroom Management, Validation of a Cleanroom Garment System, and Gowning Procedure, J. Eudy

    Principles of Wiping and Cleaning Validation, K.F. Bonnell and H. Siegerman

    Overview to Analytical and Monitoring Techniques, E. Kanegsberg

    Practical Aspects of Analyzing Surfaces, B. Schiefelbein

    How Clean Is Clean? Measuring Surface Cleanliness and Defining Acceptable Levels of Cleanliness, M.K. Chawla

    Cleaning Validations Using Extraction Techniques, K. Andrascik

    Biomedical Applications: Testing Methods for Verifying Medical Device Cleanliness, D.E. Albert

    Material Compatibility, E. Eichinger


    Part II: Applications

    Clean Critically: An Overview of Cleaning Applications, B. Kanegsberg

    Cleaning Validation of Reusable Medical Devices: An Overview of Issues in Designing, Testing, and Labeling of Reusable Devices, J.E. Broad and D.A.B. Smith

    Critical Cleaning for Pharmaceutical Applications, P. Lopolito

    Cleaning in the Food Processing Industry, H.A. Timmerman

    Electronic Assembly Cleaning Process Considerations, M. Bixenman

    Precision Cleaning in the Electronics Industry: Surfactant-Free Aqueous Chemistries, H. Wack

    Contamination-Induced Failure of Electronic Assemblies, H. Schweigart

    Surface Cleaning: Particle Removal, A.A. Busnaina

    Cleaning Processes for Semiconductor Wafer Manufacturing (Aluminum Interconnect), S. Sahbari, M. Toofan, and J. Chu

    Advanced Cleaning Processes for Electronic Device Fabrication (Copper Interconnect and Particle Cleaning), S. Sahbari and M. Toofan

    The Cleaning of Paintings, R.C. Wolbers and C. Stavroudis

    Road Map for Cleaning Product Selection for Pollution Prevention, J. Marshall

    Wax Removal in the Aerospace Industry, B. Breault, J. Soma, and C. Fouts

    Implementation of Environmentally Preferable Cleaning Processes for Military Applications, W. Ziegler and T. Torres


    Part III: Safety and Regulations

    Worker Protection and the Environment: Current Editorial Observations, B. Kanegsberg

    Health and Safety, J.L. Unmack

    Critical Cleaning and Working with Regulators: From a Regulator’s Viewpoint, M. Balagopalan

    Momentum from the Phaseout of Ozone-Depleting Solvents Drives Continuous Environmental Improvement, S.O. Andersen and M. Sheppard

    Screening Techniques for Environmental Impact of Cleaning Agents, D.J. Wuebbles


    Glossary of Terms and Acronyms


    Barbara Kanegsberg is president of BFK Solutions LLC, Pacific Palisades, California, an independent consulting company established in 1994. BFK Solutions is the industry leader in critical cleaning. As a recognized consultant in the areas of critical cleaning, contamination control, surface quality, and process validation, she helps companies optimize manufacturing cleaning processes, improve yield, resolve regulatory issues, and maintain trouble-free production. She has participated in projects that include aerospace/military equipment, electronics assembly, medical devices, engineered coatings, metals, pump repair, and optical and nanotechnological devices. She has also participated in a number of product development- and intellectual property-related projects for manufacturers of cleaning chemicals and industrial equipment. Barbara is a recipient of the U.S. EPA Stratospheric Ozone Protection Award for her achievements in implementing effective, environment-friendly manufacturing processes. She has numerous publications to her credit in the areas of surface preparation, contamination control, critical cleaning, method validation, analytical techniques, and regulatory issues.


    Ed Kanegsberg is the vice president of BFK Solutions, Pacific Palisades, California. He is also a chemical physicist and engineer who troubleshoots and solves manufacturing production problems. Ed is a recognized advisor and consultant in the areas of industrial cleaning process design and process performance. He uses his four decades of practical experience along with his background in physics and engineering to help companies solve production problems and optimize their cleaning and contamination control processes.

    … an excellent resource for the manufacturer and for those researchers and consultants like myself who support the manufacturers. … This Handbook's strongest suit is the presentation of the Kanegsbergs’ philosophy of process development and improvement. … they have produced a very useful resource in these two handbooks.
    —Darren Williams, Controlled Environments Magazine, Mar 1, 2012

    Mazel tov on your new edition!!! I really didn't know what to expect from a ‘cleaning’ book. So surprised—it is an incredible treasure trove of information!! It is really interesting, beautifully written and honestly I can't stop reading it. Thankfully it is two volumes so Scott and I don't have to fight over it. Really, it is the most fascinating technical book I've ever seen so it should fly off the shelves-or the Internet.
    —Debra Kimless-Garber MD, Scott Garber MD, DIFLUOREX

    ... a tour de force, a work written by experts who have worked at the interface between science and industry and who write from that basis, not from an ivory tower. The price of these two formidable volumes is not insignificant. But set against the cost of defective production, just for one hour’s downtime or components having to be re-worked or completely rejected, it is an investment that will pay for itself many times over. On that basis, one is more than happy to strongly recommend it.
    —Anselm Kuhn, Galvanotechnik, July 2011

    There are a number of excellent chapters specific to electronics applications; these include materials, equipment, processes and failure modes. Cleaning printed board assemblies for selected applications is on the increase where no clean has quite rightly dominated the market place for many years since the demise of CFC’s. There are many reasons why cleaning is a hot topic again and a great time for the release of an encyclopaedia on cleaning.
    —Bob Willis, Global SMT & Packaging Magazine, July 2011

    Any firm serious about managing its cleaning operations should have this book available to their staff responsible for that operation. It’s a strong contribution to the technical literature supporting industrial cleaning because of the diversity of its coverage and strengths of many chapters, …. Every chapter is replete with references—something not provided with a Google (or other search engine) Internet search.
    —John Durkee, Metal Finishing Magazine, August 2011

    Industry expert Ed Kanegsberg discusses the necessity for cleaning prior to manufacturing