Handbook of Biotransformations of Aromatic Compounds: 1st Edition (Hardback) book cover

Handbook of Biotransformations of Aromatic Compounds

1st Edition

By B.L. Goodwin

CRC Press

2,128 pages

Purchasing Options:$ = USD
Hardback: 9780415271769
pub: 2004-11-10
SAVE ~$144.00
$720.00
$576.00
x
eBook (VitalSource) : 9780429095603
pub: 2004-11-10
from $360.00


FREE Standard Shipping!

Description

Understanding the biotransformations of aromatic compounds and how they metabolize in animals, plants, and microbes, is central to the applications in a wide range of industries, such as the design and testing of natural and synthetic pharmaceuticals, oil refining, the development of agrochemicals, bioremediation, and for use in functional genomics and xenobiotics.

Presenting the most complete resource of its kind, the Handbook of Biotransformations of Aromatic Compounds examines 20,000 aromatic compounds researched since 1972, and assembled from all the major, relevant journals. The author focuses his coverage on the biotransformation in animals, plants, and microbes while remaining within the scope of aromatic compounds that contain, or are fused with, at least one aromatic C6 ring. Part One lists each compound alphabetically along with the forward and reverse mechanisms of its metabolism in specific organisms. Part Two characterizes the different types of organic reactions that have been identified - including formation and degradation, oxidations and reductions, substitution, and transfer reactions - and the enzymes associated with those reactions. The author cites selected references for enzymes that are well documented while filling in the details for those with little research literature. This book also contains a searchable CD-ROM of the author's previous work covering aromatic compounds researched from 1900 through 1972.

Presenting the most complete resource of its kind, this well-established author draws on his firsthand knowledge to organize a large body of information into a user-friendly and indispensable handbook for professionals, policymakers, and researchers alike.

Reviews

"The book is indispensable for my work, and for researchers involved in a variety of fields in academia and industry…The author is a world authority on the subject…I HIGHLY recommend this book…"

- Dr. Iqbal Gill, Head of Biotransformations/Biocatalysis Department, Roche Vitamins Inc.

"…a well-structured book covering the literature of the last thirty years….easy to use and contains plenty of interesting material…contains an immense amount of information on themetabolism of aromatic compounds."

ChemBioChem 2005, volume 6

"This book is an excellent and exhaustive source…a labour of love which should prove to be an essential reference source for those involved in the biotransformation of aromatics as it provides detailed coverage of developments within this field over the past 100 years."

biochemist.org, July 8, 2005

Table of Contents

PART 1

Alphabetical Listing of Aromatic Compounds

PART 2

REACTIONS INVOLVING THE FORMATION AND DEGRADATION OF THE AROMATIC NUCLEUS

Aromatization of 6-membered carbon and heterocyclic rings

Formation of carbon ring systems

Formation of heterocyclic ring systems

Polymerization reactions

Reactions involving carbon ring fission

Reactions involving heterocyclic ring fission

Dearomatization

Ring expansion

OXIDATIONS AND REDUCTIONS INVOLVING THE AROMATIC NUCLEUS AND NON-ORGANIC SUBSTITUENTS

Hydroxylation of the aromatic nucleus

Formation of quinones and analogues from catechols, quinols and other precursors

Free radicals from phenols

Oxidation of nuclear amino groups and analogues

Oxidation of heterocyclic amines

Reduction of nitro groups and analogues

Oxidation and reduction of sulphur atoms

Reduction of quinones and analogues

Halogens and the aromatic nucleus

Epoxide formation and reduction

Deamination of arylamines without hydroxylation

Dehydroxylation of phenols

Nitro group addition and removal

OXIDATIONS AND REDUCTIONS OF SUBSTITUENT SIDE CHAINS AND NON-AROMATIC RING SYSTEMS (WITHOUT ALTERING CHAIN LENGTH)

Hydroxylation of the carbon side-chain

Alkyl oxidation to ketone

Oxidations and reductions of alcohols, aldehydes and ketones

Reductions of acids

Deamination

Oxidative removal of substituents on amino groups

Oxidations and reductions involving nitrogen atoms

O-Dealkylation

Oxidations and reductions of non-aromatic ring systems

Sulphur replacement

Dehydroxylation

Side chain halogenation

Oxidative rearrangement

FORMATION AND DEGRADATION OF SIDE-CHAINS

Side-Chain Formation

Decarboxylation of phenolic groups without hydroxylation

Decarboxylation reactions of side-chains

Other reactions involving side-chain shortening and removal

Chain lengthening reactions

CONJUGATION AND SUBSTITUTION REACTIONS

Ester formation

Sulphamate formation

Glycoside formation

Conjugation of thiols

Formation of amides and substituted amides

Phosphorylation reactions

Ether formation

N-alkylation

Silane anhydrides

ELIMINATION OF SUBSTITUENTS

Ester hydrolysis

Hydrolysis of glycosides

Hydrolysis of amides

Hydrolysis of phosphates

Miscellaneous reactions

TRANSFER REACTIONS

Transamination

Isomerization

Migrations

Racemization

FORMATION AND REACTIONS OF NON-ARYL DOUBLE AND TRIPLE BONDS

Double and triple bond formation

Reactions of double bonds

HYDRATION OF EPOXIDES

LIGHT-FORMING REACTIONS

INDEX

BIBLIOGRAPHY

Subject Categories

BISAC Subject Codes/Headings:
MED008000
MEDICAL / Biochemistry
MED071000
MEDICAL / Pharmacology
SCI013040
SCIENCE / Chemistry / Organic