2124 Pages
by
CRC Press
2128 Pages
by
CRC Press
Also available as eBook on:
Understanding the biotransformations of aromatic compounds and how they metabolize in animals, plants, and microbes, is central to the applications in a wide range of industries, such as the design and testing of natural and synthetic pharmaceuticals, oil refining, the development of agrochemicals, bioremediation, and for use in functional genomics and xenobiotics. Presenting the most complete... Read more
PART 1
Alphabetical Listing of Aromatic Compounds
PART 2
REACTIONS INVOLVING THE FORMATION AND DEGRADATION OF THE AROMATIC NUCLEUS
Aromatization of 6-membered carbon and heterocyclic rings
Formation of carbon ring systems
Formation of heterocyclic ring systems
Polymerization reactions
Reactions involving carbon ring fission
Reactions involving heterocyclic ring fission
Dearomatization
Ring expansion
OXIDATIONS AND REDUCTIONS INVOLVING THE AROMATIC NUCLEUS AND NON-ORGANIC SUBSTITUENTS
Hydroxylation of the aromatic nucleus
Formation of quinones and analogues from catechols, quinols and other precursors
Free radicals from phenols
Oxidation of nuclear amino groups and analogues
Oxidation of heterocyclic amines
Reduction of nitro groups and analogues
Oxidation and reduction of sulphur atoms
Reduction of quinones and analogues
Halogens and the aromatic nucleus
Epoxide formation and reduction
Deamination of arylamines without hydroxylation
Dehydroxylation of phenols
Nitro group addition and removal
OXIDATIONS AND REDUCTIONS OF SUBSTITUENT SIDE CHAINS AND NON-AROMATIC RING SYSTEMS (WITHOUT ALTERING CHAIN LENGTH)
Hydroxylation of the carbon side-chain
Alkyl oxidation to ketone
Oxidations and reductions of alcohols, aldehydes and ketones
Reductions of acids
Deamination
Oxidative removal of substituents on amino groups
Oxidations and reductions involving nitrogen atoms
O-Dealkylation
Oxidations and reductions of non-aromatic ring systems
Sulphur replacement
Dehydroxylation
Side chain halogenation
Oxidative rearrangement
FORMATION AND DEGRADATION OF SIDE-CHAINS
Side-Chain Formation
Decarboxylation of phenolic groups without hydroxylation
Decarboxylation reactions of side-chains
Other reactions involving side-chain shortening and removal
Chain lengthening reactions
CONJUGATION AND SUBSTITUTION REACTIONS
Ester formation
Sulphamate formation
Glycoside formation
Conjugation of thiols
Formation of amides and substituted amides
Phosphorylation reactions
Ether formation
N-alkylation
Silane anhydrides
ELIMINATION OF SUBSTITUENTS
Ester hydrolysis
Hydrolysis of glycosides
Hydrolysis of amides
Hydrolysis of phosphates
Miscellaneous reactions
TRANSFER REACTIONS
Transamination
Isomerization
Migrations
Racemization
FORMATION AND REACTIONS OF NON-ARYL DOUBLE AND TRIPLE BONDS
Double and triple bond formation
Reactions of double bonds
HYDRATION OF EPOXIDES
LIGHT-FORMING REACTIONS
INDEX
BIBLIOGRAPHY
Alphabetical Listing of Aromatic Compounds
PART 2
REACTIONS INVOLVING THE FORMATION AND DEGRADATION OF THE AROMATIC NUCLEUS
Aromatization of 6-membered carbon and heterocyclic rings
Formation of carbon ring systems
Formation of heterocyclic ring systems
Polymerization reactions
Reactions involving carbon ring fission
Reactions involving heterocyclic ring fission
Dearomatization
Ring expansion
OXIDATIONS AND REDUCTIONS INVOLVING THE AROMATIC NUCLEUS AND NON-ORGANIC SUBSTITUENTS
Hydroxylation of the aromatic nucleus
Formation of quinones and analogues from catechols, quinols and other precursors
Free radicals from phenols
Oxidation of nuclear amino groups and analogues
Oxidation of heterocyclic amines
Reduction of nitro groups and analogues
Oxidation and reduction of sulphur atoms
Reduction of quinones and analogues
Halogens and the aromatic nucleus
Epoxide formation and reduction
Deamination of arylamines without hydroxylation
Dehydroxylation of phenols
Nitro group addition and removal
OXIDATIONS AND REDUCTIONS OF SUBSTITUENT SIDE CHAINS AND NON-AROMATIC RING SYSTEMS (WITHOUT ALTERING CHAIN LENGTH)
Hydroxylation of the carbon side-chain
Alkyl oxidation to ketone
Oxidations and reductions of alcohols, aldehydes and ketones
Reductions of acids
Deamination
Oxidative removal of substituents on amino groups
Oxidations and reductions involving nitrogen atoms
O-Dealkylation
Oxidations and reductions of non-aromatic ring systems
Sulphur replacement
Dehydroxylation
Side chain halogenation
Oxidative rearrangement
FORMATION AND DEGRADATION OF SIDE-CHAINS
Side-Chain Formation
Decarboxylation of phenolic groups without hydroxylation
Decarboxylation reactions of side-chains
Other reactions involving side-chain shortening and removal
Chain lengthening reactions
CONJUGATION AND SUBSTITUTION REACTIONS
Ester formation
Sulphamate formation
Glycoside formation
Conjugation of thiols
Formation of amides and substituted amides
Phosphorylation reactions
Ether formation
N-alkylation
Silane anhydrides
ELIMINATION OF SUBSTITUENTS
Ester hydrolysis
Hydrolysis of glycosides
Hydrolysis of amides
Hydrolysis of phosphates
Miscellaneous reactions
TRANSFER REACTIONS
Transamination
Isomerization
Migrations
Racemization
FORMATION AND REACTIONS OF NON-ARYL DOUBLE AND TRIPLE BONDS
Double and triple bond formation
Reactions of double bonds
HYDRATION OF EPOXIDES
LIGHT-FORMING REACTIONS
INDEX
BIBLIOGRAPHY
Biography
B.L. Goodwin
"The book is indispensable for my work, and for researchers involved in a variety of fields in academia and industry…The author is a world authority on the subject…I HIGHLY recommend this book…"
- Dr. Iqbal Gill, Head of Biotransformations/Biocatalysis Department, Roche Vitamins Inc.
"…a well-structured book covering the literature of the last thirty years….easy to use and contains plenty of interesting material…contains an immense amount of information on themetabolism of aromatic compounds."
ChemBioChem 2005, volume 6
"This book is an excellent and exhaustive source…a labour of love which should prove to be an essential reference source for those involved in the biotransformation of aromatics as it provides detailed coverage of developments within this field over the past 100 years."
biochemist.org, July 8, 2005
