Handbook of Design and Analysis of Experiments: 1st Edition (Hardback) book cover

Handbook of Design and Analysis of Experiments

1st Edition

Edited by Angela Dean, Max Morris, John Stufken, Derek Bingham

Chapman and Hall/CRC

960 pages | 144 B/W Illus.

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pub: 2015-06-26
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Handbook of Design and Analysis of Experiments provides a detailed overview of the tools required for the optimal design of experiments and their analyses. The handbook gives a unified treatment of a wide range of topics, covering the latest developments.

This carefully edited collection of 25 chapters in seven sections synthesizes the state of the art in the theory and applications of designed experiments and their analyses. Written by leading researchers in the field, the chapters offer a balanced blend of methodology and applications.

The first section presents a historical look at experimental design and the fundamental theory of parameter estimation in linear models. The second section deals with settings such as response surfaces and block designs in which the response is modeled by a linear model, the third section covers designs with multiple factors (both treatment and blocking factors), and the fourth section presents optimal designs for generalized linear models, other nonlinear models, and spatial models. The fifth section addresses issues involved in designing various computer experiments. The sixth section explores "cross-cutting" issues relevant to all experimental designs, including robustness and algorithms. The final section illustrates the application of experimental design in recently developed areas.

This comprehensive handbook equips new researchers with a broad understanding of the field’s numerous techniques and applications. The book is also a valuable reference for more experienced research statisticians working in engineering and manufacturing, the basic sciences, and any discipline that depends on controlled experimental investigation.


"The volumes should be of primary interest to researchers and graduate students from (bio)statistics, but also appeal to scientists where the methodology is applied to real problems. … Each section contains between two and five chapters. All chapters have been written by leading researchers. … Most of the chapters indeed provide a thorough overview of the state of the art in the theory of a specific subfield of design and analysis of experiments."

—Peter Goos, KU Leuven University of Antwerp, in Journal of the American Statistical Association, May 2017

"This handbook contains 25 thoughtfully assembled articles that have been written by leading researchers in the field of experimental design. The themes addressed by these articles are theories and computational methods in experimental design. They are well organized in seven sections that cover classical and new approaches for designing scientific experiments. Each section can be read independently from the others, and all articles within a section provide excellent references for further reading. … The reader can find here a rich theory and methodology in understanding traditional and new problems in experimental design, mostly from the frequentist point of view. At times, the material gets deep and technical but there are many useful references on theoretical and computational issues, which can be found throughout the book. Although it is hard to cover all existing research in experimental design, this handbook manages to give a comprehensive review of many fundamental approaches in experimental design. It is undoubtedly a valuable guide for researchers in statistics, as well as practitioners in the fields of engineering, medicine, biology, or any other discipline that uses experimental investigation. This book could be of value for graduate courses in advanced experimental design with a focus on optimal design theory. It could also be suitable for use as an additional text in any course in advanced experimental design."

—Tena I. Katsaounis, Ohio State University, in Technometrics, October 2016

Table of Contents

General Principles

History and Overview of Design and Analysis of Experiments Klaus Hinkelmann

Introduction to Linear Models Linda M. Haines

Designs for Linear Models

Blocking with Independent Responses John P. Morgan

Crossover Designs Mausumi Bose and Aloke Dey

Response Surface Experiments and Designs André I. Khuri and Siuli Mukhopadhyay

Design for Linear Regression Models with Correlated Errors Holger Dette, Andrey Pepelyshev, and Anatoly Zhigljavsky

Designs Accommodating Multiple Factor

Regular Fractional Factorial Designs Robert Mee and Angela Dean

Multistratum Fractional Factorial Designs Derek Bingham

Nonregular Factorial and Supersaturated Designs Hongquan Xu

Structures Defined by Factors R.A. Bailey

Algebraic Method in Experimental Design Hugo Maruri-Aguilar and Henry P. Wynn

Optimal Design for Nonlinear and Spatial Models

Optimal Design for Nonlinear and Spatial Models: Introduction and Historical Overview Douglas P. Wiens

Designs for Generalized Linear Models Anthony C. Atkinson and David C. Woods

Designs for Selected Nonlinear Models Stefanie Biedermann and Min Yang

Optimal Design for Spatial Models Zhengyuan Zhu and Evangelos Evangelou

Computer Experiments

Design of Computer Experiments: Introduction and Background Max Morris and Leslie Moore

Latin Hypercubes and Space-Filling Designs C. Devon Lin and Boxin Tang

Design for Sensitivity Analysis William Becker and Andrea Saltelli

Expected Improvement Designs William I. Notz

Cross-Cutting Issues

Robustness of Design Douglas P. Wiens

Algorithmic Searches for Optimal Designs Abhyuday Mandal, Weng Kee Wong, and Yaming Yu

Design for Contemporary Applications

Design for Discrete Choice Experiments Heiko Grossmann and Rainer Schwabe

Plate Designs in High-Throughput Screening Experiments for Drug Discovery Xianggui Qu (Harvey) and Stanley Young

Up-and-Down Designs for Dose-Finding Nancy Flournoy and Assaf P. Oron

Optimal Design for Event-Related fMRI Studies Jason Ming-Hung Kao and John Stufken


About the Editors

Angela Dean is professor emeritus in the Department of Statistics and a member of the Emeritus Academy at The Ohio State University. She is a fellow of the American Statistical Association and the Institute of Mathematical Statistics and an elected member of the International Statistical Institute. Her primary research focuses on the design of screening experiments.

Max Morris is professor and chair of the Department of Statistics at Iowa State University, where he also holds a courtesy appointment in the Department of Industrial and Manufacturing Systems Engineering. He is a fellow of the American Statistical Association. His research program focuses on the design and analysis of experiments, with special emphasis on those that involve computer models.

John Stufken is the Charles Wexler Professor in Statistics in the School of Mathematical and Statistical Sciences at Arizona State University. He is a fellow of the American Statistical Association and the Institute of Mathematical Statistics and an elected member of the International Statistical Institute. His primary area of research interest is the design and analysis of experiments.

Derek Bingham is professor in the Department of Statistics and Actuarial Science at Simon Fraser University, Burnaby. His primary research interests lie in the design and analysis of physical and computer experiments.

About the Series

Chapman & Hall/CRC Handbooks of Modern Statistical Methods

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Subject Categories

BISAC Subject Codes/Headings:
MATHEMATICS / Probability & Statistics / General