Handbook of Drug Metabolism  book cover
1st Edition

Handbook of Drug Metabolism

ISBN 9780367399856
Published June 19, 2019 by CRC Press
612 Pages

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Book Description

Bringing together nearly forty collaborators from academic and industrial laboratories, this reference furnishes an overview of the subject from a historical, kinetic, and chemical context. A source of expertise for a rapidly changing and expanding field, the book provides a framework for drug metabolism in drug discovery and development. Containing tables, drawings, photographs, and equations, it highlights the importance of pharmacokinetics and cytochrome P450, explains clearance, volume of distribution, sequential metabolism, and nonlinear kinetics, summarizes concepts of Phase 1 and 2 metabolites, evaluates tertiary amine metabolism and reactive metabolite chemistry, and more.

Table of Contents

Fundamental Aspects of Drug Metabolism. Factors Affecting Drug Metabolism. Technologies. Metabolism in Drug Discovery and Development.

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Thomas F. Woolf