2nd Edition

Handbook of Drug Screening

Edited By Ramakrishna Seethala, Litao Zhang Copyright 2009
    504 Pages 100 B/W Illustrations
    by CRC Press

    Building upon the foundation of basics discussed in the previous edition, the Second Edition provides a more in-depth look at the latest methods and technologies of advanced drug screening, an essential function of drug discovery.

    With extensively updated content and 21 new chapters, this text examines:

    • quality and efficiency of drug target validation and potential drug compound selection
    • reducing assay costs and improvement in assay technology
    • data quality improvement
    • trends in drug discovery
    • how drug screening can minimize adverse drug effects
    • recent advancements, including: high content screening; protein-protein interactions; high-throughput crystallization; lead optimization; chemoinformatics and microfluidics technologies; target validation by genomics, proteomics, and siRNA; structure-based drug design; automation; and medicinal chemistry

    Key Factors for Successful High-Throughput Screening, John G. Houston
    Critical Components in High-Throughput Screening: Challenges and New Trends, Litao Zhang, Martyn N. Banks, and John G. Houston
    Hit-to-Probe-to-Lead Optimization Strategies: A Biology Perspective to Conquer the Valley of Death, Anuradha Roy, Byron Taylor, Peter R. McDonald, Ashleigh Price, and Rathnam Chaguturu
    Signal Detection Platforms for Screening in Drug Discovery, Ramakrishna Seethala
    Proteomic Analysis in Drug Discovery, Haiteng Deng, Yang Xu, and Linqi Zhang
    Screening and Characterization of G-Protein–Coupled Receptor Ligands for Drug Discovery, Ge Zhang and Mary Ellen Cvijic
    Nuclear Hormone Receptor Screening in Drug Discovery, Ramakrishna Seethala and Litao Zhang
    Emerging Novel High-Throughput Screening Technologies for Cell-Based Assays, Ilona Kariv, Alexander A. Szewczak, Nathan W. Bays, Nadya Smotrov, and Christopher M. Moxham
    In Vitro Strategies for Ion Channel Screening in Drug Discovery, Ravikumar Peri, Mark Bowlby, and John Dunlop
    Wheat from Chaff: General andMechanistic Triage of Screening Hits for Enzyme Targets, Mark R. Harpel
    Protein Kinases and Phosphatases, Pirthipal Singh
    MicroRNA Strategies in Drug Discovery, Wishva B. Herath, Dwi S. Karolina, Arunmozhiarasi Armugam, and Kandiah Jeyaseelan
    Strategies for Screening of Biologic Therapeutics, Ian Foltz and Francesca Civoli
    Cryopreserved Cells in Functional Cell–Based HTS Assays, Geetha Shankar and Kirk McMillan
    High-Content Screening with a Special Emphasis on Cytotoxicity and Cell Health Measurementsn Ralph J. Garippa and Ann F. Hoffman
    Effective Application of DrugMetabolism and Pharmacokinetics in Drug Discovery, Sharon Diamond and Swamy Yeleswaram
    Compound Management for Drug Discovery: An Overview, Moneesh Chatterjee and Martyn N. Banks
    Practical Approach to Quantitative High Throughput Screening, Wei Zheng, Ke Liu, and James Inglese
    Enabling the Large-Scale Analysis of Quantitative High-Throughput Screening Data, Noel T. Southall, Ajit Jadhav, Ruili Huang, Trung Nguyen, and Yuhong Wang
    Application of Nanobiotechnologies for Drug Discovery, K. K. Jain
    Index

    Biography

    Ramakrishna Seethala, Litao Zhang