Handbook of Drug Screening: 2nd Edition (Hardback) book cover

Handbook of Drug Screening

2nd Edition

Edited by Ramakrishna Seethala, Litao Zhang

CRC Press

504 pages | 100 B/W Illus.

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Hardback: 9781420061680
pub: 2009-06-24
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pub: 2016-04-19
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Building upon the foundation of basics discussed in the previous edition, the Second Edition provides a more in-depth look at the latest methods and technologies of advanced drug screening, an essential function of drug discovery.

With extensively updated content and 21 new chapters, this text examines:

  • quality and efficiency of drug target validation and potential drug compound selection
  • reducing assay costs and improvement in assay technology
  • data quality improvement
  • trends in drug discovery
  • how drug screening can minimize adverse drug effects
  • recent advancements, including: high content screening; protein-protein interactions; high-throughput crystallization; lead optimization; chemoinformatics and microfluidics technologies; target validation by genomics, proteomics, and siRNA; structure-based drug design; automation; and medicinal chemistry

Table of Contents

Key Factors for Successful High-Throughput Screening, John G. Houston

Critical Components in High-Throughput Screening: Challenges and New Trends, Litao Zhang, Martyn N. Banks, and John G. Houston

Hit-to-Probe-to-Lead Optimization Strategies: A Biology Perspective to Conquer the Valley of Death, Anuradha Roy, Byron Taylor, Peter R. McDonald, Ashleigh Price, and Rathnam Chaguturu

Signal Detection Platforms for Screening in Drug Discovery, Ramakrishna Seethala

Proteomic Analysis in Drug Discovery, Haiteng Deng, Yang Xu, and Linqi Zhang

Screening and Characterization of G-Protein–Coupled Receptor Ligands for Drug Discovery, Ge Zhang and Mary Ellen Cvijic

Nuclear Hormone Receptor Screening in Drug Discovery, Ramakrishna Seethala and Litao Zhang

Emerging Novel High-Throughput Screening Technologies for Cell-Based Assays, Ilona Kariv, Alexander A. Szewczak, Nathan W. Bays, Nadya Smotrov, and Christopher M. Moxham

In Vitro Strategies for Ion Channel Screening in Drug Discovery, Ravikumar Peri, Mark Bowlby, and John Dunlop

Wheat from Chaff: General andMechanistic Triage of Screening Hits for Enzyme Targets, Mark R. Harpel

Protein Kinases and Phosphatases, Pirthipal Singh

MicroRNA Strategies in Drug Discovery, Wishva B. Herath, Dwi S. Karolina, Arunmozhiarasi Armugam, and Kandiah Jeyaseelan

Strategies for Screening of Biologic Therapeutics, Ian Foltz and Francesca Civoli

Cryopreserved Cells in Functional Cell–Based HTS Assays, Geetha Shankar and Kirk McMillan

High-Content Screening with a Special Emphasis on Cytotoxicity and Cell Health Measurementsn Ralph J. Garippa and Ann F. Hoffman

Effective Application of DrugMetabolism and Pharmacokinetics in Drug Discovery, Sharon Diamond and Swamy Yeleswaram

Compound Management for Drug Discovery: An Overview, Moneesh Chatterjee and Martyn N. Banks

Practical Approach to Quantitative High Throughput Screening, Wei Zheng, Ke Liu, and James Inglese

Enabling the Large-Scale Analysis of Quantitative High-Throughput Screening Data, Noel T. Southall, Ajit Jadhav, Ruili Huang, Trung Nguyen, and Yuhong Wang

Application of Nanobiotechnologies for Drug Discovery, K. K. Jain


About the Series

Drugs and the Pharmaceutical Sciences

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Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Pharmacology
MEDICAL / Pharmacy