Handbook of Dynein (Second Edition): 2nd Edition (Hardback) book cover

Handbook of Dynein (Second Edition)

2nd Edition

Edited by Keiko Hirose

Pan Stanford

350 pages | 34 Color Illus. | 48 B/W Illus.

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Hardback: 9789814800013
pub: 2019-03-31
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Dyneins are molecular motors that are involved in various cellular processes, such as cilia and flagella motility, vesicular transport, and mitosis. Since the first edition of this book was published in 2012, there has been a significant breakthrough: the crystal structures of the motor domains of cytoplasmic dynein have been solved and the previously unknown details of this huge and complex molecule have been unveiled. This new edition contains 14 chapters written by researchers in the US, Europe, and Asia, including 3 new chapters that incorporate new fields. The other chapters have also been substantially updated. Compared with the earlier edition, this book focuses more on the motile mechanisms of dynein, especially by biophysical methods such as cryo-EM, X-ray crystallography, and single-molecule nanometry.

Table of Contents

Dyneins: Ancient Protein Complexes Gradually Reveal Their Secrets.

L Amos & K Hirose

Structural and Functional Analysis of the Dynein Motor Domain.

T Shima & T Kon

Electron Microscopy Studies of Dynein: From Subdomains to Microtubule-Bound Assemblies.

A Roberts et al.

Subunit Architecture of the Cytoplasmic Dynein Tail.

M Ichikawa et al.

Measuring the Motile Properties of Single Dynein Molecules.

H Higuchi & C Shingyoji

Mechanics of Dynein: Motility

A Yildiz

Interactions of Multiple Dynein Motors Studied Using DNA Scaffolding.

N Derr

Cytoplasmic Dynein Force Regulation in Vitro and in Vivo.

C Wynne & R Vallee

Dynein in Endosome and Phagosome Maturation

A Rai, D Pathak & R Mallik

Dynein in Intraflagellar Transport.

K Lechtreck

Diversity of Chlamydomonas Axonemal Dyneins.

T Yagi & R Kamiya

Motility of Axonemal Dyneins

M Shiraga et al.

Axonemal Dyneins in Cilia and Flagella.

T Ishikawa

Regulatory Mechanism of Axonemal Dynein.

K Inaba

About the Editor

Keiko Hirose has been working in the field of molecular motors for more than 30 years. She has a PhD from the University of Tokyo and was a postdoctoral fellow at the University of Pennsylvania and at the MRC Laboratory of Molecular Biology, Cambridge, UK. Dr. Hirose has been working at the National Institute of Advanced Industrial Science and Technology, Japan, since 1997.

Subject Categories

BISAC Subject Codes/Headings:
SCIENCE / Life Sciences / Biophysics
SCIENCE / Biotechnology
SCIENCE / Life Sciences / Cytology
SCIENCE / Life Sciences / Biology / Molecular Biology