As many as 250,000 people in the United States have dystonia, making it the third most common movement disorder following essential tremor and Parkinson's disease.
Authoritative and reader-friendly, Handbook of Dystonia, Second Edition provides a wide-ranging overview of the latest research and developments regarding the pathogenesis, evaluation, and management of the disease. The book offers detailed coverage of every available treatment option for dystonia and includes four categorized sections on medical management, botulinum toxin injections, phenol and neurolytic therapy, and surgical intervention.
The book reviews the genetic factors of dystonia and supplies in-depth coverage of the neuroanatomy, neurophysiology, and neuropathology of the disease. It covers secondary causes of dystonia, including drug-induced and psychogenic presentations. It also examines non-motor symptoms relating to movement disorders and analyzes innovative approaches for treatment including deep brain stimulation.
New to the Second Edition:
- Four new chapters dedicated to the discussion of individual botulinum toxins recently approved to treat dystonia: Botox, Myobloc, Disport, and Xeomin
- Dystonic symptoms associated with Parkinson’s disorders
- The use of Transcranial Magnetic Stimulation (TMS) as a treatment option for dystonia
- Spasticity and its pathogenesis, evaluation, and treatment with toxins, other injectables and surgical therapies
Summarizing what is known about the disorder, the book dramatically improves the recognition and understanding of this debilitating disease.
SECTION I: EPIDEMIOLOGY AND PATHOGENESIS
Introduction to Dystonia
Joohi Shahed; Joseph Jankovic
Epidemiology Dystonia
Giovanni Defazio
Genetic Evaluation in Hereditary Dystonia
Christine Klein; Laurie J. Ozelius
Functional Anatomy of the Basal Ganglia
Jonathan W. Mink
Physiology of Primary Dystonia
Holly A. Shill; Mark Hallett
Pathology of the Dystonias
Ruth H. Walker; Kevin StP. McNaught; Daniel Perl
Neuroimaging in Dystonia
A. R. Troiano; A. J. Stoessl
SECTION II: SIGNS AND SYMPTOMS
Primary Generalized Dystonia
Johan Samanta
Cranial Dystonia
Pankaj Satija; William G. Ondo
Cervical Dystonia
Khashayar Dashtipour; Mark Lew
Limb Dystonia
Barbara I. Karp
Spasmodic Dysphonia
Tanya K. Meyer; Andrew Blitzer
Embouchure and Other Task-Specific Musician’s Dystonias
Steven E. Lo; Steven J. Frucht
Sports-Related Task-Specific Dystonia: The Yips
Charles H. Adler
Dopa-Responsive Dystonia
Masaya Segawa; Yoshiko Nomura; Nobuyoshi Nishiyama
Rapid Onset Dystonia-Parkinson
Allison Brashear
Secondary Dystonia
Arif Dalvi; Kelly E. Lyons; Rajesh Pahwa
Dystonic Symptoms Associated with Parkinsonian Disorder
Eduardo Tolosa
Drug-Induced Dystonia
Francisco Cardoso
Psychogenic Dystonia
Anette Schrag; Anthony E. Lang
Nonmotor Symptoms in Dystonia
Stewart A. Factor; Daniel Huddleston; Felicia C. Goldstein; Lynn Marie Trott
Spasticity
Volker Dietz
SECTION III: TREATMENT OPTIONS
Medical Therapy for Dystonia
Roongroj Bhidayasiri; Daniel Tarsy
Anatomic Principles for Botulinum Toxin Injection
Richard L. Barbano
Botulinum Toxin: From Molecule to Clinic
Nicole Calakos
Botulinum Toxins in the Treatment of Dystonia
Mark A. Stacy; Patrick Hickey
Botox onabotulinumtoxinA
David Charles; Chandler Gill
Myobloc rimabotulinumtoxinB
Christina Sampaio
Dysport abobotulinumtoxinA
Werner Poewe; Sascha Hering
Xeomin incobotulinumtoxinA
Dirk Dressler
Peripheral neurolysis in the treatment if dystonia
Alberto Esquenazi
Selective Denervation in Cervical Dystonia
Carlos A. Arce
Repetitive transcranial Magnetic Stimulation in the Treatment for Dystonia
Angelo Antonini; Francesca Morgante
Brain Surgery for Dystonia
Camilla Kilbane; William J. Marks, Jr.
Biography
Mark A. Stacy, Duke University Medical Center, North Carolina, USA
Handbook of Dystonia, Second Edition, will again be edited by Mark A. Stacy, whose reputation in the industry as an expert in this movement disorder has only grown since he developed the very successful first edition. Dr. Stacy, now a professor of neurology at Duke University, has attracted a team of internationally-recognised movement disorder specialists to write the first edition of the book. These experts have returned to update their chapters, and new treatment specialists have been recruited to write the new botulinum toxin chapters.
