1st Edition

Handbook of H+-ATPases

Edited By

Suguru Nakamura

ISBN 9789814411912
Published March 19, 2014 by Jenny Stanford Publishing
504 Pages 23 Color & 45 B/W Illustrations

USD $210.00

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Book Description

This handbook on vacuolar and plasma membrane H+-ATPases is the first to focus on an essential link between vacuolar H+-ATPase and the glycolysis metabolic pathway to understand the mechanism of diabetes and the metabolism of cancer cells. It presents recent findings on the structure and function of vacuolar H+-ATPase in glucose promoting assembly and signaling, in addition to describing the regulatory mechanisms of vacuolar H+-ATPase in yeast cells, neural stem cells, kidney cells, cancer cells, as well as under diabetic conditions.

Table of Contents

Vacuolar H+-ATPase Assembly

Structure of Prokaryotic V type ATPase/synthase

The function of V-ATPase in the degradation of gluconeogenic enzymes in the yeast vacuole

The Role of Vacuolar ATPase in the Regulation of Npt2a Trafficking

Cytosolic pH regulated by glucose promotes V-ATPase assembly

Vacuolar H+-ATPase (V-ATPase) activated by glucose, a possible link to diabetic disease

Vacuolar proton pump (V-ATPase) and insulin secretion

Role of V-ATPase, cytohesin-2/Arf6 and aldolase in regulation of endocytosis: Implications for diabetic nephropathy

Renal Vacuolar H+-ATPase Regulation

Long-term Regulation of Vacuolar H+-ATPase by Angiotensin II in Proximal Tubule Cells

Vacuolar H+-ATPase in Distal Renal Tubular Acidosis and Diabetes

Vacuolar H+-ATPase in Cancer and Diabetes

The a2 isoform of Vacuolar ATPase and Cancer-Related Inflammation

V-ATPases in oral squamous cell carcinoma

Vacuolar H(+)-ATPase : functional mechanism and potential as a target for cancer chemotherapy

Vacuolar H+-ATPase Maintains Neural Stem Cells in the Developing Mouse Cortex

The relationship between glucose-induced calcium signaling and activation of the plasma membrane H+-ATPase in Saccharomyces cerevisiae cells

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Dr. Nakamura received his M.D. degree from the Jiangxi Medical University in 1984 and his Ph.D. from the Tokyo Medical and Dental University in 1995. Dr. Nakamura joined Murray State University in 2003 and his current position is Associate Professor of Biological Sciences. His research is focused on the physiological studies of acid-base balance and ion transports in the kidney.