Handbook of Human Immunology: 2nd Edition (Hardback) book cover

Handbook of Human Immunology

2nd Edition

Edited by Maurice R.G. O'Gorman, Albert D. Donnenberg

CRC Press

640 pages | 130 B/W Illus.

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Hardback: 9780849319846
pub: 2008-02-15
eBook (VitalSource) : 9780429124341
pub: 2008-02-15
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Since the publication of the first edition of the Handbook of Human Immunology in 1997, major scientific achievements have directly contributed to an increased understanding of the complexities of the human immune system in health and disease. Whether as a result of the sequencing of the entire human genome, or of technological advancements, several new components of the immune system have been revealed, along with new technologies for their measurement and evaluation.

Major breakthroughs in the field include an increase in the number of recognized "clusters of differentiation" on the surface of leukocytes and associated cells, the establishment of a chemokine and chemokine receptor nomenclature system, the discovery of more than 30 lymphokines, and humanized monoclonal antibody therapy as a staple of pharmacologic armamentarium

Modeling the previous edition, the text begins with an overview of the immune system, focusing on the role of cell receptors, accessory molecules, and cytokines in immune responses and immunological disorders. It then presents a practical, easy-to-read chapter on "statistics in immunological testing"—an invaluable asset for interpreting test results, validating new tests, and developing reference ranges. Simultaneously, the text emphasizes clinically relevant immunological parameters and clarifies the basic principles underlying immune system assays, and applications and interpretations of immune tests.

A complete guide to molecular and cellular immunology for practicing clinicians, clinical laboratory professionals, and students, this resource combines basic explanations of laboratory tests with more than 100 tables full of references, and up-to-date information on new developments in immunogenetics.

Table of Contents

Preface Editors


Overview of Immunity, J.D. Folds

Statistics of Immunological Testing, A.D. Donnenberg

Human Immunoglobulins, R.G. Hamilton

The Complement System, P.Giclas

Cellular Immunology: Monitoring of Immune Therapies, T.L. Whiteside

Understanding Clinical Flow Cytometry, A.D. Donnenberg and V.S. Donnenberg

Leukemia and Lymphoma Immunophenotyping and Cytogenetics, M.A. Proytcheva

Guidelines for the Use of Flow Cytometry in the Management of Patients Infected with the Human Immunodeficiency Virus Type-1 and the Acquired Immunodeficiency Syndrome, M.R.G. O’Gorman

Role of Flow Cytometry in the Diagnosis and Monitoring .

of Primary Immunodeficiency Disease, M.R.G. O’Gorman

Detection and Characterization of the T-Cell Receptor Repertoire, G.Uzel

Human Leukocyte Differentiation Antigens, Cluster of Differentiation: Past, Present, and Future, M.R.G. O’Gorman

Immunologic Diagnosis of Autoimmunity, N.R. Rose

Autoimmune and Immune-Mediated Diseases of the Gastrointestinal Tract, S. Guandalini, M. Setty, and B. Jabri

Serologic Testing for Infectious Diseases, J.L. Schmitz

Molecular Techniques Applied to Infectious Diseases, J.S. Goodrich and M.B. Miller

Cytokines; Regulators of Immune Responses and Key Therapeutic Targets, B. Detrick, C.N. Nagineni, and J.J. Hooks

Measuring Human Cytokines, H.T. Maecker

The Human Major Histocompatibility Complex and .

DNA-Based Typing of Human Lymphocyte Antigens.

(HLA) for Transplantation, S.G. Marino, A. Jaramillo, and M.A. Fernández-Viña

Relevance of Antibody Screening and Crossmatching.

in Solid Organ, Hematopoietic Stem Cell Transplantation, .

and Blood Transfusion, C.L. Saw, D.L. Heaney, H.M. Gebel, and R.A. Bray

Functional Assessment of Immunosuppression: Monitoring

Posttransplant Alloreactivity with Flow Cytometric Mixed

Lymphocyte Cocultures, C.A. Kumar, A. Abdullah, A. Logar, P. Wilson, A. Talukdar, N. Chien, M.Singh, and R. Sindhi

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Clinical Medicine
MEDICAL / Immunology
SCIENCE / Life Sciences / Biology / Microbiology