Since the publication of the first edition of the Handbook of Human Immunology in 1997, major scientific achievements have directly contributed to an increased understanding of the complexities of the human immune system in health and disease. Whether as a result of the sequencing of the entire human genome, or of technological advancements, several new components of the immune system have been revealed, along with new technologies for their measurement and evaluation.
Major breakthroughs in the field include an increase in the number of recognized "clusters of differentiation" on the surface of leukocytes and associated cells, the establishment of a chemokine and chemokine receptor nomenclature system, the discovery of more than 30 lymphokines, and humanized monoclonal antibody therapy as a staple of pharmacologic armamentarium
Modeling the previous edition, the text begins with an overview of the immune system, focusing on the role of cell receptors, accessory molecules, and cytokines in immune responses and immunological disorders. It then presents a practical, easy-to-read chapter on "statistics in immunological testing"—an invaluable asset for interpreting test results, validating new tests, and developing reference ranges. Simultaneously, the text emphasizes clinically relevant immunological parameters and clarifies the basic principles underlying immune system assays, and applications and interpretations of immune tests.
A complete guide to molecular and cellular immunology for practicing clinicians, clinical laboratory professionals, and students, this resource combines basic explanations of laboratory tests with more than 100 tables full of references, and up-to-date information on new developments in immunogenetics.
Table of Contents
Overview of Immunity, J.D. Folds
Statistics of Immunological Testing, A.D. Donnenberg
Human Immunoglobulins, R.G. Hamilton
The Complement System, P.Giclas
Cellular Immunology: Monitoring of Immune Therapies, T.L. Whiteside
Understanding Clinical Flow Cytometry, A.D. Donnenberg and V.S. Donnenberg
Leukemia and Lymphoma Immunophenotyping and Cytogenetics, M.A. Proytcheva
Guidelines for the Use of Flow Cytometry in the Management of Patients Infected with the Human Immunodeficiency Virus Type-1 and the Acquired Immunodeficiency Syndrome, M.R.G. O’Gorman
Role of Flow Cytometry in the Diagnosis and Monitoring .
of Primary Immunodeficiency Disease, M.R.G. O’Gorman
Detection and Characterization of the T-Cell Receptor Repertoire, G.Uzel
Human Leukocyte Differentiation Antigens, Cluster of Differentiation: Past, Present, and Future, M.R.G. O’Gorman
Immunologic Diagnosis of Autoimmunity, N.R. Rose
Autoimmune and Immune-Mediated Diseases of the Gastrointestinal Tract, S. Guandalini, M. Setty, and B. Jabri
Serologic Testing for Infectious Diseases, J.L. Schmitz
Molecular Techniques Applied to Infectious Diseases, J.S. Goodrich and M.B. Miller
Cytokines; Regulators of Immune Responses and Key Therapeutic Targets, B. Detrick, C.N. Nagineni, and J.J. Hooks
Measuring Human Cytokines, H.T. Maecker
The Human Major Histocompatibility Complex and .
DNA-Based Typing of Human Lymphocyte Antigens.
(HLA) for Transplantation, S.G. Marino, A. Jaramillo, and M.A. Fernández-Viña
Relevance of Antibody Screening and Crossmatching.
in Solid Organ, Hematopoietic Stem Cell Transplantation, .
and Blood Transfusion, C.L. Saw, D.L. Heaney, H.M. Gebel, and R.A. Bray
Functional Assessment of Immunosuppression: Monitoring
Posttransplant Alloreactivity with Flow Cytometric Mixed
Lymphocyte Cocultures, C.A. Kumar, A. Abdullah, A. Logar, P. Wilson, A. Talukdar, N. Chien, M.Singh, and R. Sindhi