Handbook of Intelligent Scaffolds for Tissue Engineering and Regenerative Medicine: 2nd Edition (Hardback) book cover

Handbook of Intelligent Scaffolds for Tissue Engineering and Regenerative Medicine

2nd Edition

Edited by Gilson Khang

Pan Stanford

1,440 pages | 183 Color Illus. | 155 B/W Illus.

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Hardback: 9789814745123
pub: 2017-05-02
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Description

Millions of patients suffer from end-stage organ failure or tissue loss annually, and the only solution might be organ and/or tissue transplantation. To avoid poor biocompatibility–related problems and donor organ shortage, however, around 20 years ago a new, hybridized method combining cells and biomaterials was introduced as an alternative to whole-organ and tissue transplantation for diseased, failing, or malfunctioning organs—regenerative medicine and tissue engineering. This handbook focuses on all aspects of intelligent scaffolds, from basic science to industry to clinical applications. Its 10 parts, illustrated throughout with excellent figures, cover stem cell engineering research, drug delivery systems, nanomaterials and nanodevices, and novel and natural biomaterials. The book can be used by advanced undergraduate- and graduate-level students of stem cell and tissue engineering and researchers in macromolecular science, ceramics, metals for biomaterials, nanotechnology, chemistry, biology, and medicine, especially those interested in tissue engineering, stem cell engineering, and regenerative medicine.

Table of Contents

INTRODUCTION

Biomaterials and Manufacturing Methods for Scaffolds in Regenerative Medicine: Update 2015

Introduction

Biomaterials for Regenerative Medicine and Tissue Engineering

Scaffold Fabrication and Characterization

Concluding Remarks and Future Directions

References

CERAMIC AND METAL SCAFFOLDS

Biomineralized Matrices as Intelligent Scaffolds for Bone Tissue Regeneration

Introduction

CaP Biomaterials

CaP-Based Biomaterial-Assisted Osteogenic Differentiation of Stem Cells

CaP Matrices for Bone Tissue Engineering and Repair

CaP Mineral-Based Matrices as a Delivery Vehicle for Growth Factors and Genes

CaP-Assisted Stem Cell Osteogenesis and Bone Tissue Regeneration: Mechanistic Insights

Conclusions and Future Perspectives

References

Bioceramic and Composite Scaffolds in Drug Delivery and Bone Tissue Engineering

Introduction

Bioceramics

Nanotechnology in Bioceramics

Nanoceramics in Drug Delivery

Bone Tissue Engineering

Research Perspective

Basic Questions in Bone Tissue Engineering

Conclusions

References

Recent Development in Materials Innovation in Bone Tissue Regeneration

Overview

Materials’ Innovation

Microstructure and Morphology Optimization of Bioceramic-Based Bone Substitutes

Current Challenges and Future Directions in Bone Substitute Research

Conclusions

References

Carbonate Apatite Scaffolds for Regenerative Medicine

Introduction

Fabrication of Carbonate Apatite by Compositional Transformation Based on Dissolution-Precipitation Reaction Using a Precursor

Cell and Tissue Response to Carbonate Apatite

Porous Carbonate Apatite

Conclusions

References

Mg-Based Biodegradable Metals for Scaffolds

Introduction

Mg-Based Biodegradable Metals for Bone Scaffolds

Mg-Based Biodegradable Metals for Blood Vessel Scaffolds/Stents

Concluding Remarks

References

INTELLIGENT HYDROGELS

Functional DNA Building Blocks and Their Hydrogel Scaffolds for Biomedical Applications

Overview

DNA Nanobuilding Blocks

DNA Hydrogels

Functionalized DNA Hydrogels

Protein-Producing DNA Hydrogels

Conclusions

References

Recent Progress of Intelligent Hydrogels for Tissue Engineering

Introduction

History of Hydrogels

Properties of Hydrogel Scaffolds for Successful Tissue Engineering

Classification of Hydrogels

Conclusions

References

Polyanionic Hydrogels as Biomaterials for Tissue Engineering

Overview

Properties of Polyanionic Hydrogels

Polyanionic Hydrogels for Replacement of Biotissues

Polyanionic Hydrogels for Tissue Regeneration

Conclusions

References

Hyaluronic Acid–Based Hydrogel as a Scaffold for Tissue Engineering

Introduction

Characteristics of Hyaluronic Acid in Tissue Engineering

HA Derivatives

Fabrication of Hyaluronic Acid Hydrogels

Hyaluronic Acid–Based Hybrid Hydrogels

Conclusions and Outlook

References

Biologically Triggered Injectable Hydrogels as Intelligent Scaffolds

Introduction

Injectable Hydrogels as a Regenerative Scaffold

Enzyme-Triggered Hydrogels

Conclusions and Outlook

References

Cytocompatible and Reverse-Transformable Polymeric Hydrogel Matrices

Introduction

Polymer Hydrogel as an Artificial ECM

Physically Forming Crosslinkable Hydrogels

Stimuli-Responsive Hydrogels

Reversible and Spontaneously Forming Hydrogels

Rheological Properties of PMBV/PVA Hydrogels

Control of Cell Proliferation through PMBV/PVA Hydrogels

Differentiation Induction of Stem Cells Encapsulated in the PMBV/PVA Hydrogels

Conclusions and Future Perspectives

References

"Smart" Hydrogels in Tissue Engineering and Regenerative Medicine Applications

Introduction

Stimuli-Responsive Hydrogels: Types, Properties, and Applications

Processing of Hydrogels

Final Remarks and Future Trends

References

Cell-Encapsulating Polymeric Microgels for Tissue Repair

Introduction

Natural and Synthetic Polymers for Cell-Encapsulating Microgels

Fabrication Methods of Microgels for Cell Encapsulation

Design Considerations of Microgels for Cell Encapsulation

The Application of Cell-Encapsulating Microgels for Tissue Repair

Challenges for Clinical Translation

Summary and Future Perspectives

References

Injection Materials for the Larynx

Overview

Anatomy of the Vocal Fold

Pathologic Changes of the Vocal Fold in Glottal Insufficiency

General Principles of Injection Laryngoplasty for Vocal Fold Paralysis

General Characteristics of the Materials Currently Available for Vocal Fold Augmentation

Ideal Materials for Injection Laryngoplasty

Summary

References

Bionanocrystals in Tissue Engineering Strategies: Tools for Reinforcement, Nanopatterning, and/or Nanostructuring of Polymeric Scaffolds and Hydrogels

Introduction

Potential of PNCs in Tissue Engineering Strategies

Nanopatterned Surfaces

Nanostructured Films and Coatings

Porous Foam and Sponge Scaffolds

Fibrous Nanocomposities

Hydrogel Nanocomposites

Concluding Remarks

References

ELECTROSPINNING SCAFFOLDS

Porous Scaffolds Using Dual Electrospinning for in situ Cardiovascular Tissue Engineering

Introduction: Cardiovascular Tissue Engineering

Electrospinning

Cell Infiltration into Electrospun Scaffolds

Scaffold (An)isotropy

Controlling Scaffold Porosity

Mechanical Properties and Degradation Rate

Conclusions

References

Biofunctionalization of Electrospun Fibers for Tissue Engineering and Regenerative Medicine

Introduction

Electrospinning Process

Functionalization of Electrospun Fibers

Applications

Conclusions

References

Electrospun Fibrous Scaffolds

Introduction

Electrospinning Process

Advanced Fabrication Methods

Applications for Tissue Engineering

References

3D PRINTING FOR SCAFFOLDS

3D Printing of Tissue/Organ Scaffolds for Regenerative Medicine

Overview

The Modeling of Tissue/Organ Scaffolds

Material Selection

Technique Limitations

Conclusions and Prospects

References

3D Printing Technology Applied to Tissue Scaffolds

Introduction

3D Printing Methods Applied to Scaffolds

Summary

References

NANO-/BIOCONVERGENCE TECHNOLOGY FOR SCAFFOLDS

Nanomaterial-Assisted Tissue Engineering and Regenerative Medical Therapy

Introduction

Potential Risk of Nanomaterials

Conclusions and Future Perspectives

References

Application of Nanodevices in Sensing and Regenerative Medicine

Introduction

Fabrication of Nanodevices

Applications of Nanodevices

Conclusions

References

Micro-/Nanotech-Based Craniofacial Tissue Engineering

Overview

Micro-/Nanotech-Based Craniofacial Tissue Engineering

Conclusions

References

Carbon Nanotubes: A Kind of Novel Biomaterials for Scaffolds of Tissue Engineering

Introduction

Carbon Nanotubes in Bone Tissue Engineering

Nerve Tissue Engineering

The Others

References

ACELLULAR NATURAL MATRICES FOR SCAFFOLDS

Bacteriophage Scaffolds for Functional Assembly of Molecules and Nanomaterials

Overview

Phage Display

Phage Platform for Biological Applications

Genetic Modification of Phages to Create Inorganic Structures

Phage Display with Extended Genetic Codes

Conclusions

References

Intelligent Scaffold–Mediated Enhancement of the Viability and Functionality of Transplanted Pancreatic Islets to Cure Diabetes Mellitus

Overview

Scaffolds Fabricated with ECM Molecules Decellularized from the Pancreas

Natural Polymer–Based Scaffolds

Synthetic Polymer–Based Scaffold

Natural and Synthetic Polymer Composite–Based Scaffold

Conclusions

References

Extracellular Matrix–Derived Biomaterials: Molecularly Defined Ingredients and Processing Techniques

Introduction

Extracellular Matrix

Molecularly Defined Biomaterials

Techniques and Major Tools for Scaffolding

Summary and Future Perspectives

References

Biological-Derived Biomaterials for Stem Cell Culture and Differentiation

Introduction

Stem Cell Engineering

Biological-Derived Materials

Summary and Future Direction

References

Demineralized Dentin Matrix (DDM) Scaffolds for Alveolar Bone Engineering

History of the Demineralized Dentin Matrix

Characteristics of Scaffolds for Alveolar Bone Repair

Development of DDM Scaffolds

DDM Scaffolds with Recombinant Human BMP-2

Clinical Applications

Tooth Banks: Present and Future

References

Biomimetic Scaffold Fabrication for Tissue Engineering

Introduction

Biomimetic 2D Substrate Fabrication

Biomimetic 2D Substrate Modification

Biomimetic Surface Modification Methods

3D Scaffold Fabrication

Biomimetic Modification of 3D Scaffolds

Future Direction

Conclusions

References

SCAFFOLDS FOR TARGET ORGANS

Scaffolds for Tracheal Regeneration

Structure and Function of the Trachea

Tissue Engineering for Tracheal Stenosis

Scaffolds for Tracheal Regeneration

Cells

Bioreactors

Summary

References

Bladder Tissue Engineering

The Urinary Bladder: Function and Structure

Bladder Reconstruction and Augmentation

Materials for Bladder Tissue Engineering

Cell Seeding

Vascularization

Stem Cells in Bladder Tissue Engineering

Animal Studies and Clinical Trials

Future Perspectives: A Complete Bladder?

Scaffold Applications for Vascular Tissue Engineering

Introduction

Synthetic Biodegradable Polymer Scaffolds

Collagen and Other Biopolymer Scaffolds

Decellularized Tissue Scaffolds

Cell-Based Vascular Tissue Engineering

In situ "Cell Free" Vascular Tissue Engineering

Conclusions

References

Annulus Fibrosus Tissue Engineering: Achievements and Future Development

Introduction

Fundamentals of Annulus Fibrosus

Cells for Annulus Fibrosus Tissue Engineering

Scaffolds for Annulus Fibrosus Tissue Engineering

Growth Stimuli for Annulus Fibrosus Tissue Engineering

Concluding Remarks

References

Corneal Endothelium Regeneration: Basic Concepts

Introduction

Corneal Endothelium

Bioengineered Corneal Endothelium

Conclusions

References

DRUG DELIVERY SYSTEM FOR SCAFFOLDS

High-Throughput Screening of Extracellular Matrix–Based Biomaterials

Basic Principles

Relation to Materiomics

Future Perspectives

Classical Experiment 1: Biomaterial Array

Classical Experiment 2: Gene Expression Microarrays

References

Effect of Scaffolds with Bone Growth Factors on New Bone Formation

Introduction

Bone Lengthening in Preclinical Animal Studies

Growth Factor–/Stem Cell–Mediated Scaffolds for Bone Tissue Engineering

The Use of Scaffolds with or without Growth Factors and Cells for Clinical Trials

References

Drugs as Novel Biomaterials for Scaffolds

Overview

Drug Repositioning

Background and Structure of Fragmin and Protamine

Implications of Drug Repositioning in Tissue Engineering and Regenerative Medicine

Conclusions

References

FUTURE ENABLING TECHNOLOGY FOR SCAFFOLDS

Biocompatible Surface Coatings for Silicone-Based Implants

Overview

Surface Oxidation of Silicone Implants

Surface Coating with Bio-originated Materials

Surface Coating with Artificial Materials

Conclusions

References

Synthetic/PLGA Hybrid Scaffold for Tissue Regeneration: Update 2015

Introduction

Biomaterials for TERM

Hybrid and Composite Scaffold Biomaterials for TERM

PLGA/Natural Hybrid Scaffolds in Our Laboratory

Conclusions

References

Biomedical Applications of Silk Fibroin

Overview

Silk Fibroin Processing

Tissue Engineering Application of Silk Fibroin–Based Biomaterial

Conclusions

References

Tissue Fabrication and Regeneration by Cell Sheet Technology

Overview

Temperature-Responsive Culture Surface and Cell Sheets

Fabrication and Regeneration of 3D Tissues Using Cell Sheet Technology

Automation and Mechanization for Fabrication of 3D Tissues

Conclusions

References

Stem Cell Engineering Using Bioactive Molecules for Bone-Regenerative Medicine

Overview

First-Generation Bioactive Molecules: Proteins

Bioactive Molecules: Peptides

Bioactive Molecules: Small Molecules

Conclusions and Outlook

References

About the Editor

Gilson Khang is a professor at the Department of PolymerNano Science and Technology, Chonbuk National University (Korea) and a visiting professor at Tsinghua University, Peking University, and Zhejiang University (China) and the Wake Forest Institute of Regenerative Medicine (USA). Dr. Khang was elected as the founding Fellow of Tissue Engineering and Regenerative Medicine (FTERM) in 2012. He is a member of the Tissue Engineering and Regenerative Medicine International Society (TERMIS) and a founding member of the TERMIS-AP chapter, of which he is also the continental chair since 2015. He is also an executive board member of TERMIS Global and since 2016 the TERMIS Global president-elect. From 2004 to 2009, Dr. Khang was editor-in-chief of Journal of Tissue Engineering and Regenerative Medicine. He has also served as co-editor-in-chief of International Journal of Tissue Regeneration, in addition to being on the editorial board of many reputed scientific journals. He has co-authored/edited 10 books and published around 550 original research papers and 200 editorials, reviews, and book chapters. His major scientific contribution has been to the analysis of natural/synthetic hybrid scaffolds to reduce host inflammation reactions, as well as the commercialization of tissue-engineered cartilage, bone, retinal pigment epithelium, and corneal endothelium.

Subject Categories

BISAC Subject Codes/Headings:
MED009000
MEDICAL / Biotechnology
SCI010000
SCIENCE / Biotechnology
TEC021000
TECHNOLOGY & ENGINEERING / Material Science