Handbook of Ion Channels  book cover
1st Edition

Handbook of Ion Channels

ISBN 9781466551404
Published February 25, 2015 by CRC Press
691 Pages 20 Color & 238 B/W Illustrations

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Book Description

The New Benchmark for Understanding the Latest Developments of Ion Channels

Ion channels control the electrical properties of neurons and cardiac cells, mediate the detection and response to sensory stimuli, and regulate the response to physical stimuli. They can often interact with the cellular environment due to their location at the surface of cells. In nonexcitable tissues, they also help regulate basic salt balance critical for homeostasis. All of these features make ion channels important targets for pharmaceuticals.

Handbook of Ion Channels illustrates the fundamental importance of these membrane proteins to human health and disease. Renowned researchers from around the world introduce the technical aspects of ion channel research, provide a modern guide to the properties of major ion channels, and present powerful methods for modeling ion channel diseases and performing clinical trials for ion channel drugs.

Conveniently divided into five parts, the handbook first describes the basic concepts of permeation and gating mechanisms, balancing classic theories and the latest developments. The second part covers the principles and practical issues of both traditional and new ion channel techniques and their applications to channel research. The third part organizes the material to follow the superfamilies of ion channels. This part focuses on the classification, properties, gating mechanisms, function, and pharmacology of established and novel channel types. The fourth part addresses ion channel regulation as well as trafficking and distribution. The final part examines several ion channel-related diseases, discussing genetics, mechanisms, and pharmaceutical advances.

Table of Contents

Basic Concepts
Electricity, nerves, batteries: A short history Clay M. Armstrong
Ion selectivity and conductance Dorothy M. Kim, Jason G. McCoy, and Crina M. Nimigean
Basic mechanisms of voltage sensing Sandipan Chowdhury and Baron Chanda
Ligand-dependent gating mechanism William N. Zagotta
Mechanosensitive channels and their emerging gating mechanisms Sergei Sukharev and Andriy Anishkin

Ion Channel Methods
Patch clamping and single-channel analysis León D. Islas
Models of ion channel gating Frank T. Horrigan and Toshinori Hoshi
Utilizing Markov chains to model ion channel sequence variation and kinetics Anthony Fodor
Investigation of ion channel structure using fluorescence spectroscopy Rikard Blunck
A practical guide to solving the structure of an ion channel protein Tahmina Rahman and Declan A. Doyle
Structural study of ion channels by cryo-electron microscopy Qiu-Xing Jiang and Liang Shi
Rosetta structural modeling Vladimir Yarov-Yarovoy
Genetic methods for studying ion channel function in physiology and disease Andrea L. Meredith
Ion channel inhibitors Jon Sack and Kenneth S. Eum
High-throughput methods for ion channels Haibo Yu and Min Li

Ion Channel Families
Voltage-gated sodium channels William A. Catterall
BK channels Huanghe Yang and Jianmin Cui
Inward rectifying potassium channels Monica Sala-Rabanal and Colin G. Nichols
Two-pore domain potassium channels Leigh D. Plant and Steve A.N. Goldstein
KCNQ channels Nikita Gamper and Mark S. Shapiro
Ionotropic glutamate receptors Andrew Plested
5-HT3 receptors Sarah C.R. Lummis
GABAA receptors Trevor G. Smart
Cyclic nucleotide–gated channels Michael D. Varnum and Gucan Dai
Acid-sensing ion channels Cecilia Canessa
Degenerin/ENaC channels James D. Stockand
TRPC channels Jin-Bin Tian, Dhananjay Thakur, Yungang Lu, and Michael X. Zhu
TRPV channels Sharona E. Gordon
TRPM channels David D. McKemy
TRPML channels Qiong Gao, Xiaoli Zhang, and Haoxing Xu
CLC chloride channels and transporters Giovanni Zifarelli and Michael Pusch
Ca-activated chloride channels Xiuming Wong and Lily Jan
Store-operated CRAC channels Murali Prakriya

Ion Channel Regulation
Mechanism of G-protein regulation of K+ channels Rahul Mahajan and Diomedes E. Logothetis
Calmodulin regulation of voltage-gated calcium channels and beyond Manu Ben-Johny and David T. Yue
Phosphorylation of voltage-gated ion channels James S. Trimmer and Hiroaki Misonou
Alternative splicing Andrea L. Meredith
Single transmembrane regulatory subunits of voltage-gated potassium channels William R. Kobertz and Anatoli Lvov

Ion Channel Physiology and Diseases
Ion channels of the heart Donald M. Bers and Eleonora Grandi
Ion channels in pain J.P. Johnson, Jr.
CLC-related proteins in diseases Allan H. Bretag and Linlin Ma
Cystic fibrosis and the CFTR anion channel Yoshiro Sohma and Tzyh-Chang Hwang
Drugs targeting ion channels KeWei Wang


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Jie Zheng, PhD, is a professor in the Department of Physiology and Membrane Biology at the University of California Davis School of Medicine. He earned a PhD in physiology from Yale University and received his postdoctoral training at the Howard Hughes Medical Institute (HHMI) and the University of Washington. Dr. Zheng has published over ten book chapters and review articles as well as numerous original research papers. His current research focuses on the activation mechanism of the temperature-dependent thermoTRP channels.

Matthew Trudeau, PhD, is an associate professor in the Department of Physiology at the University of Maryland School of Medicine. He earned a PhD in physiology from the University of Wisconsin-Madison and was a postdoctoral fellow at the University of Washington and the Howard Hughes Medical Institute (HHMI). Dr. Trudeau’s current work focuses on hERG potassium channels.


"… for several years now, researchers have discussed the need for a new, updated, and modern standard work for the field particularly given the explosion of new approaches to channel research, some of which barely existed in 2001. And now we have it. Jie Zheng and Matthew Trudeau have organized an authoritative multi-author handbook covering much of the ion channel field, encompassing the conceptual, technical, organizational, and pathophysiological aspects of ion channel function … I enjoyed reading it and learned a lot, particularly in areas that I haven’t kept up with. It will be a great reference."
—Richard W. Aldrich, The Journal of General Physiology, July 2015

"… an excellent source to those wanting to understand, or better understand, basic mechanisms and the diversity of ion channels with respect to cellular function."
The Physiologist, July 2015

"This is the most comprehensive reference book on ion channels to date. It covers from basic concepts and mechanisms to advanced topics and applications. All chapters are written by leading experts in their fields."
—Yongchang Chang, MD, PhD, Laboratory of Ion Channel Biophysics, Division of Neurobiology, Barrow Neurological Institute

"Today we have single-channel recording, genes, hundreds of ion channel subtypes, evolutionary trees, crystal structures, 300,000 papers, many targeted drugs, and very many investigators contributing to this vigorous and mainstream field. The chapters in this volume are testimony to that beautiful success…"
—From the Foreword by Professor Bertil Hille, University of Washington