In the fast-developing field of nanomedicine, a broad variety of materials have been used for the development of advanced delivery systems for drugs, genes, and diagnostic agents. With the recent breakthroughs in the field, we are witnessing a new age of disease management, which is governed by precise regulation of dosage and delivery.
This book presents the advances in the use of polymeric nanomaterials for medical imaging, diagnosis, theranostics, and drug delivery. Beginning with the combinatorial approach for polymer design, it discusses star-shaped amphiphilic polymers, self-assembling polymer–drug conjugates, amphiphilic dendrimers, dendrimer nanohybrids, sustainable green polymeric nanoconstructs, chitosan-based nanogels, and multifunctional hybrid nanogels. The book provides all available information about these materials and describes in detail their advantages and disadvantages and the areas where they could be utilized successfully.
Table of Contents
Combinatorial Approach to Polymer Design for Nanomedicines
Amit Singh, Meghana Rawal, and Mansoor M. Amiji
Star-Shaped Amphiphilic Polymers as Soluble Carriers for Drug Delivery
Karolina A. Kosakowska and Scott M. Grayson
Self-Assembling Polymer–Drug Conjugates Nanomedicine for Drug Delivery
Jasbir Singh and Harmeet Kaur
Amphiphilic Dendrimers for Drug Delivery
Calvin A. Omolo et al.
Dendrimer Nanohybrids for Drug Delivery
Avinash Gothwal, Iliyas Khan, and Umesh Gupta
Physico-Chemical Bases of the Fabrication of Platforms for Encapsulating Active Compounds Using the Layer-by-Layer Method
Eduardo Guzmán, Francisco Ortega, and Ramón G. Rubio
Sustainable Green Polymeric Nanoconstructs for Active and Passive Cancer Therapeutics
Ankit Rochani, Sreejith Raveendran, and D. Sakthi Kumar
Chitosan-Based Nanogels for Biomedical Applications
Leyre Pérez-Álvarez, Leire Ruiz-Rubio, and José Luis Vilas-Vilela
Multifunctional Hybrid Nanogels for Medicine
Nanogels in Medicine
Khushwant S. Yadav and Bala Prabhakar
Vladimir Torchilin is University Distinguished Professor of pharmaceutical sciences and the Director of the Center for Pharmaceutical Biotechnology and Nanomedicine at Northeastern University, USA. His research interests include drug delivery and targeting, nanomedicine, multifunctional and stimulisensitive pharmaceutical nanocarriers, biomedical polymers, experimental cancer therapy, cancer immunology, and novel imaging agents. He has published more than 450 original papers, more than 150 reviews and book chapters, and 12 books and holds more than 40 patents. Google Scholar gives more than 66,000 citations of his work with H-index of 114. Prof. Torchilin is editor-in-chief of Drug Delivery and Current Drug Discovery Technologies and is on the editorial boards of several leading journals in the field, including Journal of Controlled Release (review editor), Bioconjugate Chemistry, Advanced Drug Delivery Reviews, European Journal of Pharmaceutics and Biopharmaceutics, Journal of Drug Targeting, Molecular Pharmaceutics, and Journal of Biomedical Nanotechnology. He is also a Full Member of the European Academy of Sciences and Fellow of the American Institute of Medical and Biological Engineering, American Association of Pharmaceutical Scientists (AAPS), and the Controlled Release Society. He is a recipient of the 1982 Lenin Prize in Science and Technology (the highest scientific award in the former USSR), the 2005 Research Achievements in Pharmaceutics and Drug Delivery Award from the AAPS, 2007 Research Achievements Award from the Pharmaceutical Sciences World Congress, 2009 AAPS Journal Award, 2009 International Journal of Nanomedicine Distinguished Scientist Award, 2010 Controlled Release Society Founders Award, 2012 Life Time Achievements Award from the Journal of Drug Targeting, 2012 Alec Bangham Life Time Award, and 2013 Blaise Pascal Medal for Biomedicine from the European Academy of Sciences.