1st Edition

Handbook of Mitochondrial Dysfunction

Edited By Shamim I. Ahmad Copyright 2019
    504 Pages 33 Color & 51 B/W Illustrations
    by CRC Press

    502 Pages 33 Color & 51 B/W Illustrations
    by CRC Press

    502 Pages 33 Color & 51 B/W Illustrations
    by CRC Press

    Mitochondria produce the chemical energy necessary for eukaryotic cell functions; hence mitochondria are an essential component of health, playing roles in both disease and aging. More than 80 human diseases and syndromes are associated with mitochondrial dysfunction; this book focuses upon diseases linked to these ubiquitous organelles. Accumulation of mitochondrial DNA damage results in mitochondrial dysfunction through two main pathways. Mutation in mitochondrial DNA causes diseases such as Kearns-Sayre syndrome and Pearson syndrome. Mutation in chromosomal DNA causes diseases such as Parkinson's disease and schizophrenia. These and many other diseases are reviewed in this book.





    Key Features







    • Presents the detailed structure of mitochondria, mitochondrial function, roles of oxidants and antioxidants in mitochondrial dysfunction.






    • Includes summary of both causes and effects of these diseases.






    • Discusses current and potential future therapies for mitochondrial dysfunction diseases






    • Explores a wide variety of diseases caused by dysfunctional mitochondria.


    Contents

    Preface ........................................................................................................................................................................... xi

    Acknowledgment......................................................................................................................................................... xiii

    About the Editor .......................................................................................................................................................... xv

    Contributors ............................................................................................................................................................... xvii

    SECTION I Introduction: Structure and Function of Mitochondria

    Chapter 1 Mitochondrial Structure and Function ....................................................................................................... 3

    Marcos Roberto de Oliveira

    Chapter 2 Structure, Function and Evolutionary Aspects of Mitochondria ................................................................ 9

    Puja Agarwal, Mehali Mitra, and Sujit Roy

    Chapter 3 Mitochondrial Genome Damage, Dysfunction and Repair ........................................................................23

    Kalyan Mahapatra, Sayanti De, and Sujit Roy

    SECTION II Mitochondrial Dysfunction and Diseases

    Chapter 4 Instability of Human Mitochondrial DNA, Nuclear Genes and Diseases ..................................................39

    Katarzyna Tonska

    Chapter 5 Kearns-Sayre Syndrome .............................................................................................................................55

    Josef Finsterer

    Chapter 6 Mitochondrial Dysfunction and Barth Syndrome......................................................................................61

    Arianna F. Anzmann, Steven M. Claypool, and Hilary Vernon

    Chapter 7 Mitochondrial Dysfunction in the Pathophysiology of Alzheimer’s Disease ..............................................79

    Isaac G. Onyango

    Chapter 8 Mitochondrial Dysfunction in Multiple Sclerosis.......................................................................................87

    Angela Dziedzic, Elzbieta Miller, Joanna Saluk-Bijak, and Michal Bijak

    Chapter 9 Mitochondrial Dysfunction in Chronic Kidney Disease.............................................................................93

    Maria V. Irazabal and Alfonso Eirin

    Chapter 10 Mitochondrial Dysfunction in Breast Cancer: A Potential Target from the Bench to Clinical

    Therapeutics.............................................................................................................................................103

    Thalita Basso Scandolara, Letícia Madureira Pacholak, Thayse Fachin Cormanique, Rodrigo Kern,

    and Carolina Panis

    Chapter 11 Mitochondrial Dysfunction and DNA Methylation in Atherosclerosis ....................................................115

    Silvio Zaina and Gertrud Lund

    Chapter 12 Mitochondrial Dysfunction and Heart Diseases ......................................................................................127

    Dao-Fu Dai

    Chapter 13 The Role of Mitochondrial Dysfunction in Mitophagy and Apoptosis and Its Relevance to Cancer .......143

    Jan Ježek

    Chapter 14 Mitochondrial Dysfunction Linking Obesity and Asthma .......................................................................151

    Naveen K. Bhatraju and Anurag Agrawal

    Chapter 15 Mitochondrial Dysfunction and Hearing Loss.........................................................................................163

    María de la Luz Arenas Sordo

    Chapter 16 Superoxide Dismutase, Mitochondrial Dysfunction, and Neurodegenerative Diseases ............................171

    Jahaun Azadmanesh and Gloria E. O. Borgstahl

    Chapter 17 Role of Post-Translational Modifications of Mitochondrial Complex I in Mitochondrial Dysfunction

    and Human Brain Pathologies .................................................................................................................191

    Vismaya, Yogachar Chithra, and Muchukunte Mukunda Srinivas Bharath

    Chapter 18 Heme Oxygenase-1 in Kidney Health and Disease: Perspective of Mitochondrial Homeostasis ..............205

    Pu Duann, Elias A. Lianos, and Pei-Hui Lin

    Chapter 19 Mitochondrial Transplantation in Myocardial Ischemia and Reperfusion Injury ....................................217

    David Blitzer, Borami Shin, Alvise Guariento, Pedro J. del Nido, and James D. McCully

    Chapter 20 Mitochondrial Dysfunction in Diabetes ...................................................................................................231

    Eric L. Johnson

    Chapter 21 Clinical Manifestation of Mitochondrial Disorders in Childhood............................................................243

    Martin Magner

    Chapter 22 Mitochondrial Dysfunction and Epilepsies ..............................................................................................265

    Bindu Parayil Sankaran and Arun B. Taly

    Chapter 23 Mitochondrial Dysfunction and Allergic Disease.....................................................................................277

    Kritika Khanna and Anurag Agrawal

    SECTION III Factors Affecting Mitochondrial Function

    Chapter 24 Role of Carnosic Acid in Protection of Brain Mitochondria ....................................................................293

    Marcos Roberto de Oliveira

    Chapter 25 Mitochondrial Dysfunction and Its Impact on Oxidative Capacity of Muscle .........................................309

    Teet Seene

    Chapter 26 The Effects of Resveratrol on the Brain Mitochondria.............................................................................319

    Marcos Roberto de Oliveira

    Chapter 27 Pathophysiology and Biomarkers of Mitochondrial Dysfunction Induced by Heavy Exercise .................335

    Sergej M. Ostojic

    Chapter 28 Mitochondrial Pathologies and Their Neuromuscular Manifestations .....................................................341

    Carlos Ortez and Andrés Nascimento

    Chapter 29 Mitochondrial Stress and Cellular Senescence..........................................................................................361

    Irene L. Tan and Michael C. Velarde

    Chapter 30 Role of Mitochondrial Dysfunction in Human Obesity ...........................................................................379

    David Albuquerque, Sara Silva, Daniel Álvarez-Vaca, Célia Aveleira, and Clévio Nóbrega

    Chapter 31 Roles of Melatonin in Maintaining Mitochondrial Welfare: Focus on Renal Cells...................................389

    Feres José Mocayar Marón, Emiliano Diez, Russel J. Reiter, and Walter Manucha

    Chapter 32 Mitochondrial Dysfunction Affecting the Peripheral Nervous System in Diabetic Neuropathy

    and Avenues for Therapy..........................................................................................................................399

    Jennifer Jossart, Taylor N. Dennis, and J. Jefferson P. Perry

    Chapter 33 Mitochondrial Dysfunction and Oxidative Stress in the Pathogenesis of Metabolic Syndrome................409

    Qiaozhu Su and Hao Wang

    SECTION IV Immunity and Toxicity

    Chapter 34 Regulation of Antiviral Immunity by Mitochondrial Dynamics ..............................................................425

    Mohsin Khan, Hasan Imam, and Saiful Anam Mir

    Chapter 35 Mitochondrial Dysfunction, Immune Systems, Their Diseases, and Possible Treatments.........................443

    Elise Jacquin, Eric Hervouet, and Michaël Boyer-Guittaut

    Chapter 36 Organophosphorus Compound-Induced Mitochondrial Disruption........................................................461

    Alan J. Hargreaves

    Chapter 37 Mitochondrial Dysfunction in Friedreich Ataxia .....................................................................................471

    Rosella Abeti, Annalisa Baccaro, and Paola Giunti

    Index............................................................................................................................................................................477

    Biography

    Shamim I. Ahmad earned his



    Master’s degree in Botany from



    Patna University, Bihar, India, and



    his PhD in Molecular Genetics



    from Leicester University, England.



    He then joined Nottingham



    Polytechnic as a grade 1 lecturer and subsequently was



    promoted to the post of Senior Lecturer. Ahmad now



    spends much of his time producing/writing medical



    books. For more than three decades he researched different



    areas of molecular biology/genetics including thymineless



    death in bacteria, genetic control of nucleotide



    catabolism, development of anti-AIDs drug, control of



    microbial infection of burns, phages of thermophilic bacteria,



    and microbial flora of Chernobyl after the nuclear



    power station accident. But his main interest is DNA



    damage and repair specifically by near-ultraviolet light



    mostly through the photolysis of biological compounds,



    production of reactive oxygen species, and their implications



    on human health including skin cancer. He also



    investigates near-ultraviolet photolysis of non-biological



    compounds such as 8-metoxypsoralen, mitomycin C, and



    their importance in psoriasis treatment and in Fanconi



    anemia. He has collaborated with the University of



    Osaka, Japan, and he and his colleagues were able to



    show that a number of naturally occurring enzymes were



    able to scavenge the reactive oxygen species.



    In 2003 he received a prestigious Asian Jewel Award



    in Britain for Excellence in Education. His long time ambition



    to produce medical books started in 2007 and since



    then he has published Molecular mechanisms of Fanconi



    Anemia, Molecular Mechanisms of Xeroderma Pigmentosum;



    Molecular Mechanisms of Cockayne Syndrome;



    Molecular Mechanisms of Ataxia Telangiectasia; Diseases



    of DNA repair; Neurodegenerative diseases; Diabetes: an



    Old Disease a New Insight, Obesity: a Practical Guide,



    Thyroid: Basic Science and Clinical Practice, and Ultraviolet



    light in Human Health, diseases and environment; also



    as a co-author the book on Diabetes: A comprehensive



    Treatise for patients and Caregivers. His most recent books



    are Reactive Oxygen Species in Biology and Human Health



    and Aging: Exploring a Complex Phenomenon.



     

    "This book presents a compilation of the current knowledge associated with
    mitochondrial dysfunction. Although titled as a handbook, it represents a
    textbook that covers multiple aspects of the role of mitochondria in human
    disease. It is an extensive and detailed review of the biological importance of
    mitochondria." - Luis F Escobar, MD., MS., Peyton Manning Children's Hospital