496 pages | 33 Color Illus. | 51 B/W Illus.
Mitochondria produce the chemical energy necessary for eukaryotic cell functions; hence mitochondria are an essential component of health, playing roles in both disease and aging. More than 80 human diseases and syndromes are associated with mitochondrial dysfunction; this book focuses upon diseases linked to these ubiquitous organelles. Accumulation of mitochondrial DNA damage results in mitochondrial dysfunction through two main pathways. Mutation in mitochondrial DNA causes diseases such as Kearns-Sayre syndrome and Pearson syndrome. Mutation in chromosomal DNA causes diseases such as Parkinson's disease and schizophrenia. These and many other diseases will be reviewed in this book.
Key selling features:
Introduction to mitochondria. Roles of reactive oxygen species in mitochondrial dysfunction. Transport of cellular mitochondrial proteins into mitochondria. Mutations in mitochondrial and chromosomal genes affecting mitochondrial functions. Diseases of mitochondrial gene mutation. Diseases and syndrome caused by mutation in nuclear genes leading to dysfunction of mitochondrial proteins. Roles of sigma-1 receptors on mitochondrial functions and neurodegenerative diseases. Mitochondrial dynamics in mitochondrial diseases. Mitochondrial protein transport in health and disease. Mitochondrial SIR3 and neurodegenerative brain disorders. Role of melatonin in mitochondrial dysfunction. Mitochondrial dysfunction in obesity. Mitochondrial dysfunction, innate immune responses and inflammation. Dysfunction of endoplasmic reticulum in neurodegeneration. Lysosomal storage disorder and mitochondrial dysfunction. Mitochondrial dysfunction in glial cells. Inflammation and mitochondrial dysfunction in neurodegenerative diseases. Roles of impaired metal ion homeostasis to mitochondrial dysfunction in neurons. Role of platelet mitochondrial dysfunction in human diseases. Targeting mitochondrial dysfunction in diabetic complication. Redox imbalance as diagnostic markers of mitochondrial diseases. Ecological significance of mitochondrial toxicants. IGF therapy to repair mitochondrial dysfunction disease. Mitochondrial theory of aging.