Handbook of Mitochondrial Dysfunction: 1st Edition (Hardback) book cover

Handbook of Mitochondrial Dysfunction

1st Edition

Edited by Shamim I. Ahmad

CRC Press

496 pages | 33 Color Illus. | 51 B/W Illus.

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Hardback: 9781138336087
pub: 2019-06-05
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Description

Mitochondria produce the chemical energy necessary for eukaryotic cell functions; hence mitochondria are an essential component of health, playing roles in both disease and aging. More than 80 human diseases and syndromes are associated with mitochondrial dysfunction; this book focuses upon diseases linked to these ubiquitous organelles. Accumulation of mitochondrial DNA damage results in mitochondrial dysfunction through two main pathways. Mutation in mitochondrial DNA causes diseases such as Kearns-Sayre syndrome and Pearson syndrome. Mutation in chromosomal DNA causes diseases such as Parkinson's disease and schizophrenia. These and many other diseases will be reviewed in this book.

Key selling features:

  • Presents the detailed structure of mitochondria, mitochondrial function, roles of oxidants and antioxidants in mitochondrial dysfunction
  • Includes summary of both causes and effects of these diseases
  • Discusses current and potential future therapies for mitochondrial dysfunction diseases
  • Explores a wide variety of diseases caused by dysfunctional mitochondria
  • Covers animal animal studies

Table of Contents

Introduction to mitochondria. Roles of reactive oxygen species in mitochondrial dysfunction. Transport of cellular mitochondrial proteins into mitochondria. Mutations in mitochondrial and chromosomal genes affecting mitochondrial functions. Diseases of mitochondrial gene mutation. Diseases and syndrome caused by mutation in nuclear genes leading to dysfunction of mitochondrial proteins. Roles of sigma-1 receptors on mitochondrial functions and neurodegenerative diseases. Mitochondrial dynamics in mitochondrial diseases. Mitochondrial protein transport in health and disease. Mitochondrial SIR3 and neurodegenerative brain disorders. Role of melatonin in mitochondrial dysfunction. Mitochondrial dysfunction in obesity. Mitochondrial dysfunction, innate immune responses and inflammation. Dysfunction of endoplasmic reticulum in neurodegeneration. Lysosomal storage disorder and mitochondrial dysfunction. Mitochondrial dysfunction in glial cells. Inflammation and mitochondrial dysfunction in neurodegenerative diseases. Roles of impaired metal ion homeostasis to mitochondrial dysfunction in neurons. Role of platelet mitochondrial dysfunction in human diseases. Targeting mitochondrial dysfunction in diabetic complication. Redox imbalance as diagnostic markers of mitochondrial diseases. Ecological significance of mitochondrial toxicants. IGF therapy to repair mitochondrial dysfunction disease. Mitochondrial theory of aging.

About the Editor

Shamim I. Ahmad received his PhD from Leicester University and has been Lecturer at Nottingham Trent University where he the British Asian Award for "Excellence in Education." He has authored or edited eleven books and dozens of peer reviewed research papers. His research interests are in the field of DNA damage and repair and associated diseases, molecular mechanisms of Fanconi anemia, role of reactive oxygen species (ROS) in health and diseases, skin cancer by sunlight, Anti-AIDS drug development, development of new procedures for treatment of cancer, viral and bacterial infections.

Subject Categories

BISAC Subject Codes/Headings:
MED071000
MEDICAL / Pharmacology
SCI017000
SCIENCE / Life Sciences / Cytology
SCI049000
SCIENCE / Life Sciences / Biology / Molecular Biology