Handbook of Mitochondrial Dysfunction  book cover
1st Edition

Handbook of Mitochondrial Dysfunction

Edited By

Shamim I. Ahmad





ISBN 9781138336087
Published June 6, 2019 by CRC Press
502 Pages 33 Color & 51 B/W Illustrations

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Book Description

Mitochondria produce the chemical energy necessary for eukaryotic cell functions; hence mitochondria are an essential component of health, playing roles in both disease and aging. More than 80 human diseases and syndromes are associated with mitochondrial dysfunction; this book focuses upon diseases linked to these ubiquitous organelles. Accumulation of mitochondrial DNA damage results in mitochondrial dysfunction through two main pathways. Mutation in mitochondrial DNA causes diseases such as Kearns-Sayre syndrome and Pearson syndrome. Mutation in chromosomal DNA causes diseases such as Parkinson's disease and schizophrenia. These and many other diseases are reviewed in this book.





Key Features







  • Presents the detailed structure of mitochondria, mitochondrial function, roles of oxidants and antioxidants in mitochondrial dysfunction.






  • Includes summary of both causes and effects of these diseases.






  • Discusses current and potential future therapies for mitochondrial dysfunction diseases






  • Explores a wide variety of diseases caused by dysfunctional mitochondria.


Table of Contents

Contents

Preface ........................................................................................................................................................................... xi

Acknowledgment......................................................................................................................................................... xiii

About the Editor .......................................................................................................................................................... xv

Contributors ............................................................................................................................................................... xvii

SECTION I Introduction: Structure and Function of Mitochondria

Chapter 1 Mitochondrial Structure and Function ....................................................................................................... 3

Marcos Roberto de Oliveira

Chapter 2 Structure, Function and Evolutionary Aspects of Mitochondria ................................................................ 9

Puja Agarwal, Mehali Mitra, and Sujit Roy

Chapter 3 Mitochondrial Genome Damage, Dysfunction and Repair ........................................................................23

Kalyan Mahapatra, Sayanti De, and Sujit Roy

SECTION II Mitochondrial Dysfunction and Diseases

Chapter 4 Instability of Human Mitochondrial DNA, Nuclear Genes and Diseases ..................................................39

Katarzyna Tonska

Chapter 5 Kearns-Sayre Syndrome .............................................................................................................................55

Josef Finsterer

Chapter 6 Mitochondrial Dysfunction and Barth Syndrome......................................................................................61

Arianna F. Anzmann, Steven M. Claypool, and Hilary Vernon

Chapter 7 Mitochondrial Dysfunction in the Pathophysiology of Alzheimer’s Disease ..............................................79

Isaac G. Onyango

Chapter 8 Mitochondrial Dysfunction in Multiple Sclerosis.......................................................................................87

Angela Dziedzic, Elzbieta Miller, Joanna Saluk-Bijak, and Michal Bijak

Chapter 9 Mitochondrial Dysfunction in Chronic Kidney Disease.............................................................................93

Maria V. Irazabal and Alfonso Eirin

Chapter 10 Mitochondrial Dysfunction in Breast Cancer: A Potential Target from the Bench to Clinical

Therapeutics.............................................................................................................................................103

Thalita Basso Scandolara, Letícia Madureira Pacholak, Thayse Fachin Cormanique, Rodrigo Kern,

and Carolina Panis

Chapter 11 Mitochondrial Dysfunction and DNA Methylation in Atherosclerosis ....................................................115

Silvio Zaina and Gertrud Lund

Chapter 12 Mitochondrial Dysfunction and Heart Diseases ......................................................................................127

Dao-Fu Dai

Chapter 13 The Role of Mitochondrial Dysfunction in Mitophagy and Apoptosis and Its Relevance to Cancer .......143

Jan Ježek

Chapter 14 Mitochondrial Dysfunction Linking Obesity and Asthma .......................................................................151

Naveen K. Bhatraju and Anurag Agrawal

Chapter 15 Mitochondrial Dysfunction and Hearing Loss.........................................................................................163

María de la Luz Arenas Sordo

Chapter 16 Superoxide Dismutase, Mitochondrial Dysfunction, and Neurodegenerative Diseases ............................171

Jahaun Azadmanesh and Gloria E. O. Borgstahl

Chapter 17 Role of Post-Translational Modifications of Mitochondrial Complex I in Mitochondrial Dysfunction

and Human Brain Pathologies .................................................................................................................191

Vismaya, Yogachar Chithra, and Muchukunte Mukunda Srinivas Bharath

Chapter 18 Heme Oxygenase-1 in Kidney Health and Disease: Perspective of Mitochondrial Homeostasis ..............205

Pu Duann, Elias A. Lianos, and Pei-Hui Lin

Chapter 19 Mitochondrial Transplantation in Myocardial Ischemia and Reperfusion Injury ....................................217

David Blitzer, Borami Shin, Alvise Guariento, Pedro J. del Nido, and James D. McCully

Chapter 20 Mitochondrial Dysfunction in Diabetes ...................................................................................................231

Eric L. Johnson

Chapter 21 Clinical Manifestation of Mitochondrial Disorders in Childhood............................................................243

Martin Magner

Chapter 22 Mitochondrial Dysfunction and Epilepsies ..............................................................................................265

Bindu Parayil Sankaran and Arun B. Taly

Chapter 23 Mitochondrial Dysfunction and Allergic Disease.....................................................................................277

Kritika Khanna and Anurag Agrawal

SECTION III Factors Affecting Mitochondrial Function

Chapter 24 Role of Carnosic Acid in Protection of Brain Mitochondria ....................................................................293

Marcos Roberto de Oliveira

Chapter 25 Mitochondrial Dysfunction and Its Impact on Oxidative Capacity of Muscle .........................................309

Teet Seene

Chapter 26 The Effects of Resveratrol on the Brain Mitochondria.............................................................................319

Marcos Roberto de Oliveira

Chapter 27 Pathophysiology and Biomarkers of Mitochondrial Dysfunction Induced by Heavy Exercise .................335

Sergej M. Ostojic

Chapter 28 Mitochondrial Pathologies and Their Neuromuscular Manifestations .....................................................341

Carlos Ortez and Andrés Nascimento

Chapter 29 Mitochondrial Stress and Cellular Senescence..........................................................................................361

Irene L. Tan and Michael C. Velarde

Chapter 30 Role of Mitochondrial Dysfunction in Human Obesity ...........................................................................379

David Albuquerque, Sara Silva, Daniel Álvarez-Vaca, Célia Aveleira, and Clévio Nóbrega

Chapter 31 Roles of Melatonin in Maintaining Mitochondrial Welfare: Focus on Renal Cells...................................389

Feres José Mocayar Marón, Emiliano Diez, Russel J. Reiter, and Walter Manucha

Chapter 32 Mitochondrial Dysfunction Affecting the Peripheral Nervous System in Diabetic Neuropathy

and Avenues for Therapy..........................................................................................................................399

Jennifer Jossart, Taylor N. Dennis, and J. Jefferson P. Perry

Chapter 33 Mitochondrial Dysfunction and Oxidative Stress in the Pathogenesis of Metabolic Syndrome................409

Qiaozhu Su and Hao Wang

SECTION IV Immunity and Toxicity

Chapter 34 Regulation of Antiviral Immunity by Mitochondrial Dynamics ..............................................................425

Mohsin Khan, Hasan Imam, and Saiful Anam Mir

Chapter 35 Mitochondrial Dysfunction, Immune Systems, Their Diseases, and Possible Treatments.........................443

Elise Jacquin, Eric Hervouet, and Michaël Boyer-Guittaut

Chapter 36 Organophosphorus Compound-Induced Mitochondrial Disruption........................................................461

Alan J. Hargreaves

Chapter 37 Mitochondrial Dysfunction in Friedreich Ataxia .....................................................................................471

Rosella Abeti, Annalisa Baccaro, and Paola Giunti

Index............................................................................................................................................................................477

...
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Editor(s)

Biography

Shamim I. Ahmad earned his



Master’s degree in Botany from



Patna University, Bihar, India, and



his PhD in Molecular Genetics



from Leicester University, England.



He then joined Nottingham



Polytechnic as a grade 1 lecturer and subsequently was



promoted to the post of Senior Lecturer. Ahmad now



spends much of his time producing/writing medical



books. For more than three decades he researched different



areas of molecular biology/genetics including thymineless



death in bacteria, genetic control of nucleotide



catabolism, development of anti-AIDs drug, control of



microbial infection of burns, phages of thermophilic bacteria,



and microbial flora of Chernobyl after the nuclear



power station accident. But his main interest is DNA



damage and repair specifically by near-ultraviolet light



mostly through the photolysis of biological compounds,



production of reactive oxygen species, and their implications



on human health including skin cancer. He also



investigates near-ultraviolet photolysis of non-biological



compounds such as 8-metoxypsoralen, mitomycin C, and



their importance in psoriasis treatment and in Fanconi



anemia. He has collaborated with the University of



Osaka, Japan, and he and his colleagues were able to



show that a number of naturally occurring enzymes were



able to scavenge the reactive oxygen species.



In 2003 he received a prestigious Asian Jewel Award



in Britain for Excellence in Education. His long time ambition



to produce medical books started in 2007 and since



then he has published Molecular mechanisms of Fanconi



Anemia, Molecular Mechanisms of Xeroderma Pigmentosum;



Molecular Mechanisms of Cockayne Syndrome;



Molecular Mechanisms of Ataxia Telangiectasia; Diseases



of DNA repair; Neurodegenerative diseases; Diabetes: an



Old Disease a New Insight, Obesity: a Practical Guide,



Thyroid: Basic Science and Clinical Practice, and Ultraviolet



light in Human Health, diseases and environment; also



as a co-author the book on Diabetes: A comprehensive



Treatise for patients and Caregivers. His most recent books



are Reactive Oxygen Species in Biology and Human Health



and Aging: Exploring a Complex Phenomenon.



 

Reviews

"This book presents a compilation of the current knowledge associated with
mitochondrial dysfunction. Although titled as a handbook, it represents a
textbook that covers multiple aspects of the role of mitochondria in human
disease. It is an extensive and detailed review of the biological importance of
mitochondria." - Luis F Escobar, MD., MS., Peyton Manning Children's Hospital