Handbook of Neurophotonics: 1st Edition (Hardback) book cover

Handbook of Neurophotonics

1st Edition

Edited by Francesco S. Pavone, Shy Shoham

CRC Press

600 pages | 32 Color Illus. | 118 B/W Illus.

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Hardback: 9781498718752
pub: 2020-04-15
Available for pre-order. Item will ship after 15th April 2020

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The Handbook of Neurophotonics provides a dedicated overview of neurophotonics, covering the use of advanced optical technologies to record, stimulate, and control the activity of the brain, yielding new insight and advantages over conventional tools due to the adaptability and non-invasive nature of light.

Including 32 colour figures, this book addresses functional studies of neurovascular signaling, metabolism, electrical excitation, and hemodynamics, as well as clinical applications for imaging and manipulating brain structure and function. The unifying theme throughout is not only to highlight the technology, but to show how these novel methods are becoming critical to breakthroughs that will lead to advances in our ability to manage and treat human diseases of the brain.

Key Features:

  • Provides the first dedicated book on state-of-the-art optical techniques for sensing and imaging across at the cellular, molecular, network, and whole brain levels.
  • Highlights how the methods are used for measurement, control, and tracking of molecular events in live neuronal cells, both in basic research and clinical practice.
  • Covers the entire spectrum of approaches, from optogenetics to functional methods, photostimulation, optical dissection, multiscale imaging, microscopy, and structural imaging.
  • Includes chapters that show use of voltage-sensitive dye imaging, hemodynamic imaging, multiphoton imaging, temporal multiplexing, multiplane microscopy, optoacoustic imaging, near-infrared spectroscopy, and miniature neuroimaging devices to track cortical brain activity.

Table of Contents

Miniaturized Optical Neuroimaging Systems - Hang Yu, Janaka Senarathna, Betty M. Tyler, Nitish V. Thakor, Arvind P. Pathak

Functional Imaging with Light-Sheet Microscopy - Raghav K. Chhetri and Philipp J. Keller

Two-Photon Microscopy in the Mammalian Brain - Hod Dana and Shy Shoham

Light Field Microscopy for in vivo Ca2+ imaging - Tobias Nöbauer and Alipasha Vaziri

Genetically Encoded Activity Indicators - Chenchen Song and Thomas Knöpfel

Functional Optoacoustic Imaging - Daniel Razansky

Imaging deep in the brain with wavefront engineering - Changhuei Yang and Roarke Horstmeyer

Nanoscopic Imaging to Understand Synaptic Function - Daniel Choquet

Chemical Clearing of Brains - Hans Ulrich Dodt

Advanced light-sheet microscopy to explore brain structure on organ-wide scale - Francesco Pavone

Optogenetic modulation of neural circuits - Ofer Yizhar

Molecular photoswitches for synthetic optogenetics - Shai Berlin and Ehud Isacoff

Applications of nanoparticles for optical modulation of neuronal behavior - Paul Stoddart

Optical Stimulaton of Neural Circuits in Freely-Moving Animals - Eran Stark

Holographic Optical Neural Interfaces (HONIs) - Shy Shoham

Multi-photon Nanosurgery - Francesco Pavone

High resolution diffuse optical tomography of the human brain - Adam Eggebrecht

Human Brain Imaging by Optical Coherence Tomography - David Boas

Acousto Optic Cerebral Monitoring - Michal Balberg and Revital Pery-Shechter

Neurophotonic vision restoration - Shy Shoham

Optical cochlear implants - Claus Peter Richter

Label-ree fluorescence interrogation of brain tumors - Laura Marcu

Higher Harmonic Generation Imaging for Neuropathology - Nikolay Kuzmin, Sander Idema, Eleonora Aronica, Philip C. de Witt Hamer, Pieter Wesseling, Marie Louise Groot

About the Editors

Francesco S. Pavone is full professor at the University of Florence in the Department of Physics and at the European Laboratory for Non-Linear Spectroscopy (LENS), and group leader at the Biophotonics Laboratories. He obtained a PhD in optics in 1993 and spent two years as postdoctoral fellow at the Ecole Normale Superieure with the group of Claude Cohen Tannoudjy (Nobel Prize, 1997). His research group is involved in
developing new microscopy techniques for high-resolution and high-sensitivity imaging, and laser manipulation purposes. These techniques have been applied in singlemolecule biophysics, single-cell imaging, and optical manipulation. He is also engaged in tissue imaging research, for which nonlinear optical techniques have been applied to skin and neural tissue imaging. He is the author of more than 100 peer-reviewed journal articles, has delivered more than 60 invited talks. He coordinates various European projects and has organized international congresses. He is director of the international PhD program at LENS. He is on the editorial board of the journal Neurophotonics and is a principal investigator for the Human Brain Project, an EU Flagship initiative.

Shy Shoham is an Associate Professor at the Department of Biomedical Engineering in the Technion - Israel Institute of Technology. He was born in Rehovot, Israel, and holds a B.Sc. degree in Physics from Tel Aviv University and a Ph.D. in Bioengineering from the University of Utah. After completing his Ph.D., he was a Lewis-Thomas postdoctoral fellow at the department of Molecular Biology, Princeton University. In 2005 he joined the Technion's faculty of Biomedical Engineering, where he established the Neural Interface Engineering laboratory. His lab focuses on the development of implant-less retinal prostheses aimed at restoring vision loss from outer-retinal degenerative diseases, and on developing advanced technologies for acoustic neuromodulation, microscopic neuro-imaging and for bioengineering brain-like tissues. He is a recipient of a starting grant from the European Research Council, and of the Daniel Shiran and Juludan awards for engineering advances in bio-medicine, and is a member of the editorial boards of Journal of Neural Engineering, and of Translational Vision Science & Technology.

About the Series

Series in Cellular and Clinical Imaging

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Subject Categories

BISAC Subject Codes/Headings:
SCIENCE / Physics
SCIENCE / Life Sciences / Neuroscience