1st Edition
Handbook of Nuclear Medicine and Molecular Imaging for Physicists - Three Volume Set
This state-of-the-art set of handbooks provides medical physicists with a comprehensive overview of the field of nuclear medicine. In addition to describing the underlying, fundamental theories of the field, it includes the latest research and explores the practical procedures, equipment, and regulations that are shaping the field and it's future. This set is split into three volumes, respectively titled: Instrumentation and Imaging Procedures; Modelling, Dosimetry and Radiation Protection; and Radiopharmaceuticals and Clinical Applications.
Volume one, Instrumentation and Imaging Procedures, focuses primarily on providing a comprehensive review into the detection of radiation, beginning with an introduction to the history of nuclear medicine to the latest imaging technology. Volume two, Modelling, Dosimetry and Radiation Protection, explores the applications of mathematical modelling, dosimetry, and radiation protection in nuclear medicine. The third and final volume, Radiopharmaceuticals and Clinical Applications, highlights the production and application of radiopharmaceuticals and their role in clinical nuclear medicine practice.
These books will be an invaluable resource for libraries, institutions, and clinical and academic medical physicists searching for a complete account of what defines nuclear medicine.
- The most comprehensive reference available providing a state-of-the-art overview of the field of nuclear medicine
- Edited by a leader in the field, with contributions from a team of experienced medical physicists, chemists, engineers, scientists, and clinical medical personnel
- Includes the latest practical research in the field, in addition to explaining fundamental theory and the field's history
1. The History of Nuclear Medicine
Bo-Anders Jönsson
2. Basics of Nuclear Physics
Gudrun Alm Carlsson and Michael Ljungberg
3. Basics of Radiation Interaction in Matter
Michael Ljungberg
4. Radionuclide Production
Hans Lundqvist
5. Radiometry
Mats Isaksson
6. Scintillation Detectors
Per Roos
7. Semiconductor Detectors
Per Roos
8. Gamma Spectroscopy
Christopher Rääf
9. Properties of the Digital Image
Katarina Sjögreen Gleisner
10. Digital Image Processing
Johan Gustafsson
11. Machine-Learning
Karl Åström
12. Image File Structures in Nuclear Medicine
Charles Herbst
13. The Scintillation Camera
Jonathan Gear
14. Collimators for Gamma Ray Imaging
Roel van Holen
15. Image Acquisition Protocols
Jonathan Gear
16. Single Photon Emission Computed Tomography (SPECT) and SPECT/CT Hybrid Imaging
Michael Ljungberg and Kjell Erlandssson
17. Dedicated Tomographic Single Photon Systems
Chi Liu and Jing Wu
18. Positron Emission Tomography (PET)
Stefaan Vandenberghe
19. Dead Time Effects in Nuclear Medicine Imaging Studies
Carlos Uribe and Anna Celler
20. Principles of Iterative Reconstruction for Emission Tomography
Andrew J. Reader
21. Clinical Molecular PET/CT Hybrid Imaging
Dimitris Visvikis
22. Clinical Molecular PET/MRI Hybrid Imaging
Bernard Sattler
23. Quality Assurance of Nuclear Medicine Systems
John Dickson
24. Calibration and Traceability
Brian E. Zimmerman
25. Activity Quantification from Planar images
Katarina Sjögreen Gleisner
26. Quantitation in Emission Tomography
Brian F. Hutton, Kjell Erlandsson and Kris Thielemans
27. Multicenter studies: Hardware and Software Requirements
Terez Sera, Ronald Boellaard, Andres Kaalep and Michael Ljungberg
28. Pre-Clinical Molecular Imaging Systems
Magnus Dahlbom
29. Monte Carlo simulations of Nuclear Medicine Imaging Systems
David Sarrut and Michael Ljungberg
30. Beta and Alpha Particle Autoradiography
Anders Örbom, Brian W. Miller and Tom Bäck
31. Principles behind Computed Tomography (CT)
Mikael Gunnarsson and Kristina Ydström
32. Principles behind Magnetic Resonance Imaging (MRI)
Ronnie Wirestam
Volume II: Dosimetry and Radiation Protection .
1. Introduction to Biostatistics
Johan Gustafsson and Markus Nilsson
2. Radiobiology
Lidia Strigari and Marta Cremonesi
3. Diagnostic Dosimetry
Lennart Johansson and Martin Andersson
4. Time-Activity Curves: Data, Models, Curve Fitting and Model Selection
Gerhard Glatting
5. Tracer Kinetic Modelling and its use in PET Quantification
Mark Lubberink and Michel Koole
6. Principles of Radiological Protection in Healthcare
Sören Mattsson
7. Controversies in Nuclear Medicine Dosimetry
Michael G. Stabin
8. Monte Carlo Simulation of Photon and Electron Transport in Matter
José M. Fernández-Varea
9. Patient Models for Dosimetry Applications
Michael G. Stabin
10. Patient-Specific Dosimetry Calculations
Manuel Bardiés, Naomi Clayton, Gunjan Kayal and Alex Vergara Gil
11. Whole Body Dosimetry
Jonathan Gear
12. Personalized Dosimetry in Radioembolization
Remco Bastiaannet and Hugo W.A.M. de Jong
13. Thyroid Imaging and Dosimetry
Michael Lassmann and Heribert Hänscheid
14. Bone Marrow Dosimetry
Cecilia Hindorf
15. Cellular and Multicellular Dosimetry
Roger W. Howell
16. Alpha-Particle Dosimetry
Stig Palm
17. Staff Radiation Protection
Lena Jönsson
18. IAEA support to Nuclear Medicine
Gian Luca Poli
Volume III: Radiopharmaceuticals and Clinical Applications.
1. Principles behind Radiopharmacy
Thuy A. Tran and Erik Samén
2. Radiopharmaceuticals for diagnostics: Planar/SPECT
Jim Ballinger and Jacek Koziorowski
3. Radiopharmaceuticals for diagnostics: PET
Philip Elsinga
4. Radiopharmaceuticals for radionuclide therapy
Meltem Ocak, Emre Demirci, Jessie R. Nedrow and Rebecca Krimins
5. Design Considerations for a Radiopharmaceutical Production Facility
Nic Gillings
6. Methods and Equipment for Quality Control of Radiopharmaceuticals
Rolf Zijlma, Danique Giesen, Yvette Kruiter, Philip Elsinga and Gert Luurtsema
7. Environmental Compliance and Control for Radiopharmaceutical Production: Commercial Manufacturing and Extemporaneous Preparation
Ching-Hung Chiu, Ya-Yao Huang, Wen-Yi Chang and Jacek Koziorowski
8. GMP - rules and recommendations
Oliver Neels
9. Management of Radioactive Waste in Nuclear Medicine
Lena Jönsson and Hanna Holstein
10. Translation of Radiopharmaceuticals: Mouse to Man
Pedro Fragoso Costa, Latifa Rbah-Vidal, An Aerts, Fijs W.B. van Leeuwen and Margret Schottelius
11. Radionuclide Bone Scintigraphy
Kanhaiyalal Agrawal and Gopinath Gnanasegaran
12. Radionuclide Examinations of the Kidneys
Martin Šámal and Jiří Trnka
13. Neuroimaging in Nuclear Medicine
Anne Larsson Strömvall and Susanna Jakobson Mo
14. Methodology and Clinical Implementation of Ventilation/Perfusion Tomography for Diagnosis and Follow-up of Pulmonary Embolism and Other Pulmonary Diseases Clinical use of hybrid V/P SPECT-CT
Marika Bajc and Ari Lindqvist
15. Myocardiac Perfusion Imaging
Elin Trägårdh, David Minarik and Mark Lubberink
16. Infection and Inflammation
Erik H.J.G. Aarntzen and Andor W.J.M. Glaudemans
17. Special Considerations In Pediatric Nuclear Medicine
Sofie Lindskov Hansen, Søren Holm, Liselotte Højgaard and Lise Borgwardt
18. Antibody-Based Radionuclide Imaging
Steffie Peters, Erik H.J.G. Aarntzen and Sandra Heskamp
19. Radionuclide-Based Diagnosis and Therapy of Prostate Cancer
Sven-Erik Strand, Mohamed Altai, Joanna Strand and David Ulmert
20. Peptide Receptor Radionuclide Therapy for Neuroendocrine Tumors
Anna Sundlöv and Katarina Sjögreen Gleisner
21. Lymphoscintigraphy
Rimma Axelsson, Maria Holstensson and Ulrika Estenberg
22. Diagnostic Ultrasound
Tomas Jansson
23. Clinical Trials - Purpose and Procedures
Anna Sundlöv
24. Introduction to Patient Safety and Improvement Knowledge
Tomas Kirkhorn
25. Closing remarks
László Pávics
Biography
Michael Ljungberg is a Professor at Medical Radiation Physics, Lund, Lund University, Sweden. He started his research in the Monte Carlo field in 1983 through a project involving a simulation of whole-body counters but later changed the focus to more general applications in nuclear medicine imaging and SPECT. As a parallel to his development of the Monte Carlo code SIMIND, he started working in 1985 with quantitative SPECT and problems related to attenuation and scatter. After obtaining his PhD in 1990, he received a research assistant position that allowed him to continue developing SIMIND for quantitative SPECT applications and establish successful collaborations with international research groups. At this time, the SIMIND program also became used world-wide. Dr. Ljungberg later became an associate professor in 1994 and he received, after a couple of years working clinically as a nuclear medicine medical physicist, a full professorship in the Science Faculty at Lund University in 2005. He became the Head of the Department of Medical Radiation Physics at Lund University in 2013 and a full professor in the Medical Faculty at Lund University in 2015.
Beside from the development of SIMIND to include also new camera system such as CZT detectors, his research includes an extensive project in oncological nuclear medicine, where he, with colleagues, develop dosimetry methods based on quantitative SPECT, Monte-Carlo absorbed dose calculations, and methods for accurate 3D dose planning for internal radionuclide therapy. During the recent years, his has been focused on implementing Monte-Carlo based image reconstruction in SIMIND. He is also involved in the undergraduate education of medical physicists and bio-medical engineers and are supervising MSc and PhD students. In 2012, Professor Ljungberg became a member of the European Association of Nuclear Medicines task group on Dosimetry and served there for six years. He has published over 100 original papers, 18 conference proceedings, 18 books and book chapters and 14 peer-reviewed review papers.
"This is a high quality, three volume set, bound in striking glossy red and black. The formatting is clear and the text printed in dark grey ink, an unusual choice that nevertheless makes the dense pages of text, formulae, grey and white diagrams and photographs an easier read during prolonged study. Edited by professor of medical radiation physics Michael Ljungberg from Lund University, a renowned authority on Monte Carlo modelling, it includes contributions from medical physicists who will be familiar names to many in the UK community. The content is predominantly written from a European perspective, although a chapter on the IAEA is included to provide some broader international context.
Volume I covers instrumentation and imaging procedures. This wideranging volume opens with a brief history of nuclear medicine before moving on to discuss radiation and detector physics, and the details of gamma cameras, PET, CT, MR and hybrid systems, as well as more niche imaging technologies. There are shorter chapters on acquisition protocols for clinical imaging, providing examples of how this knowledge is applied in practice. Volume II covers modelling, dosimetry and radiation protection. This volume provides the reader with a grounding in biostatistics, radiobiology, kinetic analysis and radiation protection, before a detailed and focused discussion of the application of these principles in dosimetry and radiation safety. Volume III covers radiopharmaceuticals and clinical applications. It begins with an overview of the principles behind radiopharmacy before moving on to the details of radiopharmaceuticals, all aspects of their production, and both clinical and research applications…The set covers a wide range of relevant material…each chapter stands on its own merits and provides valuable, in-depth information from subject experts…Ljundberg’s trilogy would make an excellent addition to any nuclear medicine department library."
— Dr Heather Williams, consultant medical physicist, The Christie NHS Foundation Trust, Manchester in RAD Magazine, May, 2023
