Handbook of Nuclear Medicine and Molecular Imaging for Physicists - Three Volume Set  book cover
1st Edition

Handbook of Nuclear Medicine and Molecular Imaging for Physicists - Three Volume Set

Edited By

Michael Ljungberg

ISBN 9781138593350
Published April 25, 2022 by CRC Press
1024 Pages 673 B/W Illustrations

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Book Description

This state-of-the-art set of handbooks provides medical physicists with a comprehensive overview of the field of nuclear medicine. In addition to describing the underlying, fundamental theories of the field, it includes the latest research and explores the practical procedures, equipment, and regulations that are shaping the field and it's future. This set is split into three volumes, respectively titled: Instrumentation and Imaging Procedures; Modelling, Dosimetry and Radiation Protection; and Radiopharmaceuticals and Clinical Applications.

Volume one, Instrumentation and Imaging Procedures, focuses primarily on providing a comprehensive review into the detection of radiation, beginning with an introduction to the history of nuclear medicine to the latest imaging technology. Volume two, Modelling, Dosimetry and Radiation Protection, explores the applications of mathematical modelling, dosimetry, and radiation protection in nuclear medicine. The third and final volume, Radiopharmaceuticals and Clinical Applications, highlights the production and application of radiopharmaceuticals and their role in clinical nuclear medicine practice.

These books will be an invaluable resource for libraries, institutions, and clinical and academic medical physicists searching for a complete account of what defines nuclear medicine.

  • The most comprehensive reference available providing a state-of-the-art overview of the field of nuclear medicine
  • Edited by a leader in the field, with contributions from a team of experienced medical physicists, chemists, engineers, scientists, and clinical medical personnel
  • Includes the latest practical research in the field, in addition to explaining fundamental theory and the field's history

Table of Contents

 Volume I: Instrumentation and Images Processing.

1.  The History of Nuclear Medicine
Bo-Anders Jönsson

2.  Basics of Nuclear Physics
Gudrun Alm Carlsson and Michael Ljungberg

3.  Basics of Radiation Interaction in Matter
Michael Ljungberg

4.  Radionuclide Production
Hans Lundqvist

5.  Radiometry
Mats Isaksson

6.  Scintillation Detectors
Per Roos

7.  Semiconductor Detectors
Per Roos

8.  Gamma Spectroscopy
Christopher Rääf

9.  Properties of the Digital Image
Katarina Sjögreen Gleisner

10.  Digital Image Processing
Johan Gustafsson

11.  Machine-Learning
Karl Åström

12.  Image File Structures in Nuclear Medicine
Charles Herbst

13.  The Scintillation Camera 
Jonathan Gear

14.  Collimators for Gamma Ray Imaging
Roel van Holen

15.  Image Acquisition Protocols
Jonathan Gear

16.  Single Photon Emission Computed Tomography (SPECT) and SPECT/CT Hybrid Imaging
Michael Ljungberg and Kjell Erlandssson

17.  Dedicated Tomographic Single Photon Systems
Chi Liu and Jing Wu

18.  Positron Emission Tomography (PET)
Stefaan Vandenberghe

19.  Dead Time Effects in Nuclear Medicine Imaging Studies
Carlos Uribe and Anna Celler

20.  Principles of Iterative Reconstruction for Emission Tomography
Andrew J. Reader

21.  Clinical Molecular PET/CT Hybrid Imaging
Dimitris Visvikis

22.  Clinical Molecular PET/MRI Hybrid Imaging
Bernard Sattler

23.  Quality Assurance of Nuclear Medicine Systems
John Dickson

24.  Calibration and Traceability
Brian E. Zimmerman

25.  Activity Quantification from Planar images
Katarina Sjögreen Gleisner

26.  Quantitation in Emission Tomography
Brian F. Hutton, Kjell Erlandsson and Kris Thielemans

27.  Multicenter studies: Hardware and Software Requirements
Terez Sera, Ronald Boellaard, Andres Kaalep and  Michael Ljungberg

28.  Pre-Clinical Molecular Imaging Systems
Magnus Dahlbom

29.  Monte Carlo simulations of Nuclear Medicine Imaging Systems
David Sarrut and Michael Ljungberg

30.  Beta and Alpha Particle Autoradiography
Anders Örbom, Brian W. Miller and Tom Bäck

31.  Principles behind Computed Tomography (CT)
Mikael Gunnarsson and Kristina Ydström

32.  Principles behind Magnetic Resonance Imaging (MRI)
Ronnie Wirestam


Volume II: Dosimetry and Radiation Protection .

1.  Introduction to Biostatistics
Johan Gustafsson and Markus Nilsson

2.  Radiobiology
Lidia Strigari and Marta Cremonesi

3.  Diagnostic Dosimetry
Lennart Johansson and Martin Andersson

4.  Time-Activity Curves: Data, Models, Curve Fitting and Model Selection
Gerhard Glatting

5.  Tracer Kinetic Modelling and its use in PET Quantification
Mark Lubberink and Michel Koole

6.  Principles of Radiological Protection in Healthcare
Sören Mattsson

7.  Controversies in Nuclear Medicine Dosimetry
Michael G. Stabin

8.  Monte Carlo Simulation of Photon and Electron Transport in Matter
José M. Fernández-Varea

9.  Patient Models for Dosimetry Applications
Michael G. Stabin

10.  Patient-Specific Dosimetry Calculations
Manuel Bardiés, Naomi Clayton, Gunjan Kayal and Alex Vergara Gil

11.  Whole Body Dosimetry
Jonathan Gear

12.  Personalized Dosimetry in Radioembolization
Remco Bastiaannet and Hugo W.A.M. de Jong

13.  Thyroid Imaging and Dosimetry
Michael Lassmann and Heribert Hänscheid

14.  Bone Marrow Dosimetry
Cecilia Hindorf

15.  Cellular and Multicellular Dosimetry
Roger W. Howell

16.  Alpha-Particle Dosimetry
Stig Palm

17.  Staff Radiation Protection
Lena Jönsson

18.  IAEA support to Nuclear Medicine
Gian Luca Poli

 Volume III: Radiopharmaceuticals and Clinical Applications.

1.  Principles behind Radiopharmacy
Thuy A. Tran and Erik Samén

2.  Radiopharmaceuticals for diagnostics: Planar/SPECT
Jim Ballinger and Jacek Koziorowski

3.  Radiopharmaceuticals for diagnostics: PET
Philip Elsinga

4.  Radiopharmaceuticals for radionuclide therapy
Meltem Ocak, Emre Demirci, Jessie R. Nedrow and Rebecca Krimins

5.  Design Considerations for a Radiopharmaceutical Production Facility
Nic Gillings

6.  Methods and Equipment for Quality Control of Radiopharmaceuticals
Rolf Zijlma, Danique Giesen, Yvette Kruiter, Philip Elsinga and Gert Luurtsema

7.  Environmental Compliance and Control for Radiopharmaceutical Production: Commercial Manufacturing and Extemporaneous Preparation
Ching-Hung Chiu, Ya-Yao Huang, Wen-Yi Chang and Jacek Koziorowski

8.  GMP - rules and recommendations
Oliver Neels

9.  Management of Radioactive Waste in Nuclear Medicine
Lena Jönsson and Hanna Holstein

10.  Translation of Radiopharmaceuticals: Mouse to Man
Pedro Fragoso Costa, Latifa Rbah-Vidal, An Aerts, Fijs W.B. van Leeuwen and Margret Schottelius

11.  Radionuclide Bone Scintigraphy
Kanhaiyalal Agrawal and Gopinath Gnanasegaran

12.  Radionuclide Examinations of the Kidneys
Martin Šámal and Jiří Trnka

13.  Neuroimaging in Nuclear Medicine
Anne Larsson Strömvall and Susanna Jakobson Mo

14.  Methodology and Clinical Implementation of Ventilation/Perfusion Tomography for Diagnosis and Follow-up of Pulmonary Embolism and Other Pulmonary Diseases Clinical use of hybrid V/P SPECT-CT
Marika Bajc and Ari Lindqvist

15.  Myocardiac Perfusion Imaging
Elin Trägårdh, David Minarik and Mark Lubberink

16.  Infection and Inflammation
Erik H.J.G. Aarntzen and Andor W.J.M. Glaudemans

17.  Special Considerations In Pediatric Nuclear Medicine
Sofie Lindskov Hansen, Søren Holm,  Liselotte Højgaard and Lise Borgwardt

18.  Antibody-Based Radionuclide Imaging
Steffie Peters, Erik H.J.G. Aarntzen and Sandra Heskamp

19.  Radionuclide-Based Diagnosis and Therapy of Prostate Cancer
Sven-Erik Strand,  Mohamed Altai, Joanna Strand and David Ulmert

20.  Peptide Receptor Radionuclide Therapy for Neuroendocrine Tumors
Anna Sundlöv and Katarina Sjögreen Gleisner

21.  Lymphoscintigraphy
Rimma Axelsson, Maria Holstensson and Ulrika Estenberg

22.  Diagnostic Ultrasound
Tomas Jansson

23.  Clinical Trials - Purpose and Procedures
Anna Sundlöv

24.  Introduction to Patient Safety and Improvement Knowledge
Tomas Kirkhorn

25.  Closing remarks
László Pávics

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Michael Ljungberg is a Professor at Medical Radiation Physics, Lund, Lund University, Sweden. He started his research in the Monte Carlo field in 1983 through a project involving a simulation of whole-body counters but later changed the focus to more general applications in nuclear medicine imaging and SPECT. As a parallel to his development of the Monte Carlo code SIMIND, he started working in 1985 with quantitative SPECT and problems related to attenuation and scatter. After obtaining his PhD in 1990, he received a research assistant position that allowed him to continue developing SIMIND for quantitative SPECT applications and establish successful collaborations with international research groups. At this time, the SIMIND program also became used world-wide. Dr. Ljungberg later became an associate professor in 1994 and he received, after a couple of years working clinically as a nuclear medicine medical physicist, a full professorship in the Science Faculty at Lund University in 2005. He became the Head of the Department of Medical Radiation Physics at Lund University in 2013 and a full professor in the Medical Faculty at Lund University in 2015.

Beside from the development of SIMIND to include also new camera system such as CZT detectors, his research includes an extensive project in oncological nuclear medicine, where he, with colleagues, develop dosimetry methods based on quantitative SPECT, Monte-Carlo absorbed dose calculations, and methods for accurate 3D dose planning for internal radionuclide therapy. During the recent years, his has been focused on implementing Monte-Carlo based image reconstruction in SIMIND. He is also involved in the undergraduate education of medical physicists and bio-medical engineers and are supervising MSc and PhD students. In 2012, Professor Ljungberg became a member of the European Association of Nuclear Medicines task group on Dosimetry and served there for six years. He has published over 100 original papers, 18 conference proceedings, 18 books and book chapters and 14 peer-reviewed review papers.