Handbook of Nuclear Medicine and Molecular Imaging for Physicists : Radiopharmaceuticals and Clinical Applications, Volume III book cover
1st Edition

Handbook of Nuclear Medicine and Molecular Imaging for Physicists
Radiopharmaceuticals and Clinical Applications, Volume III

  • Available for pre-order. Item will ship after December 16, 2021
ISBN 9781138593312
December 16, 2021 Forthcoming by CRC Press
280 Pages 153 B/W Illustrations

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Book Description

This state-of-the-art handbook, the third and final in a series that provides medical physicists with a comprehensive overview into the field of nuclear medicine, focuses on highlighting the production and application of radiopharmaceuticals. With this, the book also describes the chemical composition of these compounds, as well as some of the main clinical applications where radiopharmaceuticals may be used.

Following an introduction to the field of radiopharmacy, three chapters in this book are dedicated towards in-depth descriptions of common radionuclides and radiopharmaceuticals used during diagnostic studies utilizing planar/Single Photon Emission Computed Tomography (SPECT) imaging, in addition to during Positron Emission Tomography (PET) imaging, and, finally, radiotherapy. These chapters are followed by those describing procedures relating to quality control and manufacturing (good manufacturing practices) also encompassing aspects such as environmental compliance. Furthermore, this volume illustrates how facilities handling these chemicals should be designed to comply with set regulations.

Like many pharmaceuticals, the development of radiopharmaceuticals relies heavily on the use of mouse models. Thus, the translation of radiopharmaceuticals (i.e., the process undertaken to assure that the functionality and safety of a newly developed drug is maintained also in a human context), is covered in a later chapter. This is followed by a chapter emphasising the importance of safe waste disposal and how to assure that these procedures meet the requirements set for the disposal of hazardous waste.

Several chapters have also been dedicated towards describing various medical procedures utilizing clinical nuclear medicine as a tool for diagnostics and therapeutics. As physicists may be involved in clinical trials, a chapter describing the procedures and regulations associated with these types of studies is included. This is followed by a chapter focusing on patient safety and another on an imaging modality not based on ionizing radiation – ultrasound. Finally, the last chapter of this book discusses future perspectives of the field of nuclear medicine.

This text will be an invaluable resource for libraries, institutions, and clinical and academic medical physicists searching for a complete account of what defines nuclear medicine.

  • The most comprehensive reference available providing a state-of-the-art overview of the field of nuclear medicine
  • Edited by a leader in the field, with contributions from a team of experienced medical physicists, chemists, engineers, scientists, and clinical medical personnel
  • Includes the latest practical research in the field, in addition to explaining fundamental theory and the field's history

Table of Contents

1.  Principles behind Radiopharmacy
Thuy A. Tran and Erik Samén

2.  Radiopharmaceuticals for diagnostics: Planar/SPECT
Jim Ballinger and Jacek Koziorowski

3.  Radiopharmaceuticals for diagnostics: PET
Philip Elsinga

4.  Radiopharmaceuticals for radionuclide therapy
Meltem Ocak, Emre Demirci, Jessie R. Nedrow and Rebecca Krimins

5.  Design Considerations for a Radiopharmaceutical Production Facility
Nic Gillings

6.  Methods and Equipment for Quality Control of Radiopharmaceuticals
Rolf Zijlma, Danique Giesen, Yvette Kruiter, Philip Elsinga and Gert Luurtsema

7.  Environmental Compliance and Control for Radiopharmaceutical Production: Commercial Manufacturing and Extemporaneous Preparation
Ching-Hung Chiu, Ya-Yao Huang, Wen-Yi Chang and Jacek Koziorowski

8.  GMP - rules and recommendations
Oliver Neels

9.  Management of Radioactive Waste in Nuclear Medicine
Lena Jönsson and Hanna Holstein

10.  Translation of Radiopharmaceuticals: Mouse to Man
Pedro Fragoso Costa, Latifa Rbah-Vidal, An Aerts, Fijs W.B. van Leeuwen and Margret Schottelius

11.  Radionuclide Bone Scintigraphy
Kanhaiyalal Agrawal and Gopinath Gnanasegaran

12.  Radionuclide Examinations of the Kidneys
Martin Šámal and Jiří Trnka

13.  Neuroimaging in Nuclear Medicine
Anne Larsson Strömvall and Susanna Jakobson Mo

14.  Methodology and Clinical Implementation of Ventilation/Perfusion Tomography for Diagnosis and Follow-up of Pulmonary Embolism and Other Pulmonary Diseases Clinical use of hybrid V/P SPECT-CT
Marika Bajc and Ari Lindqvist

15.  Myocardiac Perfusion Imaging
Elin Trägårdh, David Minarik and Mark Lubberink

16.  Infection and Inflammation
Erik H.J.G. Aarntzen and Andor W.J.M. Glaudemans

17.  Special Considerations In Pediatric Nuclear Medicine
Sofie Lindskov Hansen, Søren Holm,  Liselotte Højgaard and Lise Borgwardt

18.  Antibody-Based Radionuclide Imaging
Steffie Peters, Erik H.J.G. Aarntzen and Sandra Heskamp

18.  Radionuclide-Based Diagnosis and Therapy of Prostate Cancer
Sven-Erik Strand,  Mohamed Altai, Joanna Strand and David Ulmert

20.  Peptide Receptor Radionuclide Therapy for Neuroendocrine Tumors
Anna Sundlöv and Katarina Sjögreen Gleisner

21.  Lymphoscintigraphy
Rimma Axelsson, Maria Holstensson and Ulrika Estenberg

22.  Diagnostic Ultrasound
Tomas Jansson

23.  Clinical Trials - Purpose and Procedures
Anna Sundlöv

24.  Introduction to Patient Safety and Improvement Knowledge
Tomas Kirkhorn

25.  Closing remarks
László Pávics




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Michael Ljungberg is a Professor at Medical Radiation Physics, Lund, Lund University, Sweden. He started his research in the Monte Carlo field in 1983 through a project involving a simulation of whole-body counters but later changed the focus to more general applications in nuclear medicine imaging and SPECT. As a parallel to his development of the Monte Carlo code SIMIND, he started working in 1985 with quantitative SPECT and problems related to attenuation and scatter. After obtaining his PhD in 1990, he received a research assistant position that allowed him to continue developing SIMIND for quantitative SPECT applications and establish successful collaborations with international research groups. At this time, the SIMIND program also became used world-wide. Dr. Ljungberg later became an associate professor in 1994 and he received, after a couple of years working clinically as a nuclear medicine medical physicist, a full professorship in the Science Faculty at Lund University in 2005. He became the Head of the Department of Medical Radiation Physics at Lund University in 2013 and a full professor in the Medical Faculty at Lund University in 2015.

Beside from the development of SIMIND to include also new camera system such as CZT detectors, his research includes an extensive project in oncological nuclear medicine, where he, with colleagues, develop dosimetry methods based on quantitative SPECT, Monte-Carlo absorbed dose calculations, and methods for accurate 3D dose planning for internal radionuclide therapy. During the recent years, his has been focused on implementing Monte-Carlo based image reconstruction in SIMIND. He is also involved in the undergraduate education of medical physicists and bio-medical engineers and are supervising MSc and PhD students. In 2012, Professor Ljungberg became a member of the European Association of Nuclear Medicines task group on Dosimetry and served there for six years. He has published over 100 original papers, 18 conference proceedings, 18 books and book chapters and 14 peer-reviewed review papers.