4th Edition

Handbook of Obesity - Volume 1 Epidemiology, Etiology, and Physiopathology

Edited By George A. Bray, Claude Bouchard Copyright 2024
    667 Pages 134 Color & 83 B/W Illustrations
    by CRC Press

    667 Pages 134 Color & 83 B/W Illustrations
    by CRC Press

    The fifth edition of Volume 1 of Handbook of Obesity written by global experts covers the basic science aspects under the broad topic areas of epidemiology, etiology, and pathophysiology of obesity. Divided into 5 sections and detailed in 66 chapters, this edition covers the important advances occurring over the past decades. With a focus on science of obesity and factors participating in the etiology of obesity, this topic is studied from biological, behavioural, and environmental perspectives.

    Volume 1 is structured into 5 parts:

    • Part 1 focuses on the history, definitions, and prevalence of the obesity. It identifies the historical references to excess weight, obesity in art and literature, direct and surrogate measurements of adiposity and obesity related traits, epidemiology of obesity around the globe, and age, sex, and ethnic variation completes this part of the volume
    • Part 2 explains the biological determinants of obesity. It explains the bioenergetics, energy dissipation mechanisms and exposure to experimental overfeeding, genetic and epigenetic evidence, metabolic rates, energy expenditure and energy partitioning, and the evidence on infections and adiposity
    • Part 3 describes the behavioral determinants of obesity. It deals with chapters related to food, beverages, and ingestive behavior, dealing with smoking, breast-feeding, and sleep duration and pattern, and sedentary behavior, occupational work, and leisure-time physical activity and obesity
    • Part 4 comprises of chapters explaining the environmental, social, and cultural determinants of obesity. The chapters in this section focus on the role of agriculture and the food industry in the current obesity epidemic, social and economic aspects of obesity, and ethnic and cultural differences, and environmental pollutants
    • Part 5 of this volume discusses the health consequences of obesity. The chapters address important topics such obesity and heart disease, lipoprotein metabolism, insulin resistance and diabetes, metabolic syndrome, cancer, hepatic biology, pulmonary functions, and arthritis and gout, mental health and quality of life, growth and health disorders in pediatric populations, and on bias and discrimination affecting the obese persons.


    About the Editors

    Associate Editors


    Introduction to Volume 1


    1. From Hippocrates to the Obesity Society: A Brief History

    George A. Bray and Marta Sumińska

    2. Obesity in Art and Literature

    Fiona Haslam and David Haslam

    3. Measurement of Total Adiposity, Regional Fat Depots, and Ectopic Fat

    Steven B. Heymsfield, Brooke Smith, and Matthew D. Robson

    4. Anthropometric Indicators of Adiposity in Relation to the Gold Standards

    Peter T. Katzmarzyk

    5. Worldwide and Regional Prevalence of Obesity

    Jacob C. Seidell

    6. Age, Sex, Ethnicity, and Other Sources of Variation in the Prevalence of Obesity

    Sohyun Park and Heidi M. Blanck


    7. Bioenergetics and Obesity

    Matthew D. Lynes and Yu-Hua Tseng

    8. Mitochondrial Metabolic Inefficiencies in Skeletal Muscle: Implications for Obesity and Weight Loss

    Mary-Ellen Harper, Ruth McPherson, and Robert Dent

    9. Human Experimental Overfeeding

    Claude Bouchard and George A. Bray

    10. Biology of Calorie Restriction and Intermittent Fasting

    Leonie Heilbronn, Kai Liu, and Luigi Fontana

    11. Genetic Epidemiology and Obesity

    Karri Silventoinen

    12. Genetic Variation and Obesity

    Ruth J.F. Loos

    13. Single-Gene Defects and Obesity

    Héléna Mosbah, Christine Poitou, and Karine Clément

    14. Micro and Long RNAs as Regulators in Obesity

    Jean-Francois Landrier, Flavie Sicard, and Lourdes Mounien

    15. Epigenetics and Obesity

    Charlotte Ling and Sonia Garcia-Calzon

    16. T he Role of Adipocyte Precursors in Development and Obesity

    Tammy Ying and Rebecca A. Simmons

    17. Small Animal Models of Obesity

    Heike Münzberg, Christopher D. Morrison, and J. Michael Salbaum

    18. Obesity in Nonhuman Primates

    Barbara C. Hansen, Daniel Harrison, Vernon Volante, Nana Gletsu-Miller, and Kai-Lin Catherine Jen

    19. The Transcriptome, Proteome, and Metabolome of Obesity

    Monalisa Hota, Lijin Wang, Pratap Seshachalam, and Sujoy Ghosh

    20. CNS Regulation of Energy Balance

    Justin L. Grobe and Matthew J. Potthoff

    21. Gastrointestinal Regulation of Energy Balance

    Timothy Sean Kairupan, Nova Hellen Kapantow, and Akio Inui

    22. Gut Microbiome and Obesity

    Kristina Martinez-Guryn and Eugene B. Chang

    23. Sympathetic Nervous System and Obesity

    Elisabeth Lambert

    24. Hypothalamic–Pituitary Hormones and Obesity

    Jonathan Q. Purnell, Mary Samuels, and Maria Fleseriu

    25. Brown, Beige, and White Adipocyte Development

    Shingo Kajimura

    26. Adipose Tissue Metabolism, Adipokines, and Obesity

    Ricardo J. Samms and Philipp E. Scherer

    27. Hepatic, Visceral, Pancreatic, and Cardiac Fat Deposition

    Amalia Gastaldelli

    28. Skeletal Muscle Metabolism and Obesity

    Polina M. Krassovskaia, Nicholas T. Broskey, and Joseph A. Houmard

    29. Resting Metabolic Rate, Thermic Effect of Food, and Obesity

    Yves Schutz and Abdul Dulloo

    30. Energy Cost of Exercise, Post-Exercise Metabolic Rates, and Obesity

    Robert Ross, Erin Miller, Emily John, and Laura Guzmán Caballero

    31. Energy Partitioning, Substrate Oxidation Rates, and Obesity

    Angelo Tremblay, Margriet Westerterp-Plantenga, and Patrick Schrauwen

    32. COVID-19, Other Microbial Infections, and Obesity

    Md Akheruzzaman, Vijay Hegde, and Nikhil V. Dhurandhar


    33. Obesity and Dietary Intake

    Eunjin Cheon, Lissa A. Davis, Vinicius M. Valicente, Yu Wang, and Richard D. Mattes

    34. Beverages and Obesity: A Review of Current Scientific Evidence

    Miaobing Zheng, Sofus C. Larsen, Nanna J. Olsen, and Berit L. Heitmann

    35. Obesity and Sedentary Time at Work and Home

    Stuart J. H. Biddle and Gregory J. H. Biddle

    36. Leisure Time Physical Activity and Obesity

    Julianne G. Clina, R. Drew Sayer, and James O. Hill

    37. Role of Early Life Nutrition and Breastfeeding on Obesity Development

    Maryam Kebbe, Kelsey Goynes, and Leanne M. Redman

    38. Tobacco Use, Marijuana Use, Vaping, and Obesity

    Bernard F. Fuemmeler, Kristina L. Tatum, and D. Jeremy Barsell

    39. Sleep and Obesity

    Silvia Cerolini and Caterina Lombardo

    40. Eating Disorders and Obesity

    Jonathan M. Mond and Timothy Gill


    41. The Role of the Food Industry in Obesity

    Martin Binks

    42. Transportation Policies and Obesity

    James E. Peterman and David R. Bassett, Jr.

    43. Urban Environment and Obesity

    Katherine R. White and Lawrence D. Frank

    44. Social and Economic Factors Related to Obesity across the Globe

    Penny Gordon-Larsen and Pasquale E. Rummo

    45. Influence of Culture on Obesity

    Alison Tovar, Peter T. Katzmarzyk, and Aviva Must

    46. Environmental Chemicals and Obesity

    Sumira Phatak, Amanda S. Janesick, Thaddeus T. Schug, Jerrold J. Heindel, and Bruce Blumberg


    47. Obesity and Mortality

    Thorkild I.A. Sørensen, Justin C. Brown, and Terese Sara Høj Jørgensen

    48. Obesity and Heart Disease

    Alexandra M. Sanchez, Nadia I. Abelhad, Andrew Elagizi, Sergey Kachur, Hector O. Ventura, and Carl J. Lavie

    49. Obesity and Hypertension

    John E. Hall, Ana C. M. Omoto, Jussara M. do Carmo, Alexandre A. da Silva, Zhen Wang, Alan J. Mouton, Xuan Li, and Michael E. Hall

    50. Obesity and Lipoprotein Metabolism

    Sally Chiu and Ronald M. Krauss

    51. Obesity and Insulin Resistance

    John P. Kirwan and Christopher L. Axelrod

    52. Obesity and Type 2. Diabetes

    Norbert Stefan

    53. Obesity and Metabolic Syndrome

    André Tchernof and Jean-Pierre Després

    54. Obesity and Cancer

    Alpa V. Patel and Lauren R. Teras

    55. Obesity and Inflammation

    Sierra Nance, Ramiah Jacks, and Carey Lumeng

    56. Obesity, Gallbladder, and Gastrointestinal Diseases

    Michael Camilleri and Andres Acosta

    57. Obesity and Liver Diseases

    Münevver Demir, Josephine Frohme, and Frank Tacke

    58. Obesity, Lung Function, and Lung Disease

    Anne E. Dixon and Swati A. Bhatawadekar

    59. Obesity and Gout

    Lorraine Watson and Edward Roddy

    60. Obesity, Osteoarthritis, and Bone Disorders

    Sanjay Mediwala and Dennis T. Villareal

    61. Obesity and Cognitive Decline

    Adam Tabak, Vince Fazekas-Pongor, Stefano Tarantini, Priya Balasubramanian, Anna Csiszar, and Zoltan Ungvari

    62. Obesity, Mental Health, and Health-Related Quality of Life

    Osnat C. Melamed, Peter Selby, and Valerie H. Taylor

    63. Obesity and Reproductive Dysfunction

    Ronald Swerdloff, Waleed Butt, and Christina Wang

    64. Obesity in Pregnancy Complications and Outcomes

    Amy M. Valent and Aaron B. Caughey

    65. Obesity, Growth, Development, Metabolic Disorder, and Insulin Resistance in Pediatrics

    Nicola Santoro, Alfonso Galderisi, and Sonia Caprio

    66. Bias, Discrimination, and Obesity

    Rebecca M. Puhl



    George A. Bray, MD, MACP, MACE, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, United States

    Claude Bouchard, PhD, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, United States

    Peter T. Katzmarzyk, PhD, FACSM, FTOS, FAHA, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, United States

    John P. Kirwan, PhD, Integrated Physiology and Molecular Medicine Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States

    Leanne M. Redman, PhD, Reproductive Endocrinology and Women’s Health Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, United States

    Philip R. Schauer, MD, Metamor Institute, Pennington Biomedical Research Center, Baton Rouge, Louisiana