5th Edition

Handbook of Obesity - Volume 2 Clinical Applications

Edited By George A. Bray, Claude Bouchard Copyright 2024
    542 Pages 90 Color & 50 B/W Illustrations
    by CRC Press

    542 Pages 90 Color & 50 B/W Illustrations
    by CRC Press

    Volume 2 of the 5th Edition of the Handbook of Obesity spotlights on clinical applications for evaluation, diagnosis, prevention, and treatment of obesity. It covers on the several major developments occurred between the previous and the new edition, including the effect of SARS-CoV-2 on people with obesity, the concept of “Precision Medicine”, and new medications approved by USFDA aiding patients with obesity weight loss of 15 to 20%.

    This volume is structured into 5 parts:

    • Part 1 provides insights from evolution on changes in diet and physical activity, and the implications and results for preventing obesity, health care costs associated with obesity and the cost-effectiveness of obesity prevention and treatment
    • Part 2 deals with evaluation of overweight patients, approaches for classifying obesity and using this knowledge to evaluate patients, and addressing ethnic and racial considerations in evaluating patients with obesity
    • Part 3 explains the impact of lifestyle in managing obesity, which include behavioural management, diet, dietary composition, and meal timing, and the effects of physical activity and exercise in weight loss and weight loss maintenance
    • Part 4 is focused on medications in the management of obesity. This includes drug selection, various classes of drugs, combination of drugs affecting weight loss, effect of herbal agents on weight loss and treatment of obesity in pediatric populations, genetic diseases causing obesity and the role of drugs in treating the dyslipidemias
    • Part 5 discusses bariatric surgery, its history, procedure and effects in details, and other surgical techniques including electric stimulation of the vagus nerve, gastric balloons, intestinal liners, and liposuction


    About the Editors

    Associate Editors


    Introduction to Volume 2


    1. Dietary Changes in Human Evolution: Implications for the Prevention of Obesity

    Peter Andrews and Richard Johnson

    2. Evolutionary Changes in Physical Activity, Diet, and Energy Expenditure: Implications for the Prevention of Obesity

    Herman Pontzer

    3. Prevention of Obesity in Adults

    Suzanne Phelan

    4. The Prevention of Obesity in Children and Adolescents

    Tim Lobstein and Louise Baur

    5. Re-engineering the Built Environment: Progress in Schools, Worksites, Neighborhoods, and Communities

    Stephanie T. Broyles and Maura M. Kepper

    6. The Economic Costs of Obesity

    Adam Biener, John Cawley, and Chad Meyerhoefer

    7. Cost-Effectiveness of Obesity Prevention and Treatment

    Jaithri Ananthapavan, Marj Moodie, and Victoria Brown

    8. Role of Government and Non-government Organizations in the Obesity Pandemic and Its Prevention

    Simon Barquera, Mariel White, Gabriela Argumedo, Carolina Batis, and Juan Rivera-Dommarco

    9. Role of Reimbursement in the Delivery of Treatment for Obesity in Adults and Children

    Chika Vera Anekwe, Veronica R. Johnson, Matthew J. Townsend, and Fatima Cody Stanford


    10. Classification, Evaluation, and Staging of the Patient with Obesity

    Robert F. Kushner and Amanda Velazquez

    11. Indicators of Central Adiposity: A Critical Evaluation of Their Usefulness

    Ian J. Neeland, Jean-Pierre Després, André C. Carpentier, and Paul Poirier

    12. Genetic Obesity Syndromes

    I. Sadaf Farooqi and Stephen O’Rahilly

    13. Ethnic and Racial Considerations in the Evaluation of the Patient with Obesity

    Peter T. Katzmarzyk, Sean Wharton, Fatima Cody Stanford, and Daniel G. Aaron


    14. Best Practices: Obesity and the Primary Care Providers

    Christine Gallagher, Donna H. Ryan, and William Dietz

    15. In-Person Behavioral Approaches for Weight Management

    Jena S. Tronieri and Thomas A. Wadden

    16. Behavioral Interventions Delivered Remotely

    Christoph Höchsmann and Corby K. Martin

    17. Cultural Considerations in Behavioral Therapy for the Management of Obesity

    Robert L. Newton, Jr., Elva Arredondo, Patricia Dionicio, and Noe C. Crespo

    18. Diet Composition and Weight Loss: Is a Calorie a Calorie?

    Kevin D. Hall

    19. Circadian Rhythms and Weight Loss: Timed Food Intake

    Emily N.C. Manoogian, Nikko R. Gutierrez, Erika Padilla, and Michael J. Wilkinson

    20. Comparison of Modern-Millennial Diets

    Monica Dinu, Daniela Martini, Francesco Sofi, Mauro Serafini, Marisa Porrini, and Donato Angelino

    21. Dietary Energy Density and Its Contribution to Weight Control

    Faris M. Zuraikat and Barbara J. Rolls

    22. Dietary Patterns as a Basis for Diet Selection

    Catherine M. Champagne

    23. Physical Activity and Weight Loss: Volume, Intensity, and Mode

    John M. Jakicic and Renee J. Rogers

    24. Modifying Sedentary Behavior for the Prevention and Treatment of Obesity

    Bethany Barone Gibbs

    25. Preventing Weight Regain after Weight Loss

    Stephen D. Anton and Michael G. Perri

    26. Personalized and Precision Nutrition in the Management of Obesity: Can We Tailor the Treatment to the Patient?

    George Thom and Mike Lean


    27. Drug-Associated Weight Gain and Clinical Alternatives

    Barbara Ameer and Michael A. Weintraub

    28. Mechanisms of Drug Action in Obesity

    M. Furkan Burak, Nawfal W. Istfan, and Caroline M. Apovian

    29. Metabolic Effects of Progressive Weight Loss

    Faidon Magkos

    30. Older Drugs Used to Manage Obesity: Sympathomimetics and Orlistat

    Frank L. Greenway and George A. Bray

    31. Serotonergic Drugs for Treating Obesity

    Mireille J. Serlie

    32. Antidiabetic Drugs That Reduce Weight and Are Cardioprotective

    Carolina M. Perdomo, Javier Escalada, and Gema Frühbeck

    33. Approved Combination Agents: Phentermine/Topiramate

    W. Timothy Garvey

    34. Approved Combination Agents: Naltrexone-Bupropion

    Igho J. Onakpoya and Carl J. Heneghan

    35. Drugs That Affect Body Weight: The Glucagon-Like Peptide-1. Agonists

    Randa Ghazal Asswad and John P.H. Wilding

    36. Hydrogels in the Treatment of Obesity

    Frank L. Greenway

    37. Dual and Triple-Action Peptides

    Thinzar Min and Stephen C. Bain

    38. Antiobesity Medications on the Horizon

    Sarah R. Barenbaum and Louis J. Aronne

    39. Treatments for Rare Forms of Genetic Obesity

    Joan C. Han, Nandini Basuray, and Andrea M. Haqq

    40. Special Issues in Using Medications in Children and Adolescents

    Jaime M. Moore, Stephen R. Daniels, and Claudia K. Fox

    41. Dietary Supplements and Weight Management

    Carol J. Haggans, Rebecca B. Costello, Leila G. Saldanha, Abby G. Ershow, and William T. Cefalu


    42. Historical Overview of Metabolic and Bariatric Surgery

    Henry Buchwald

    43. Overview: Current Metabolic Operations and Long-Term Outcomes

    Robert C. Ross, Vance L. Albaugh, Ali Aminian, and Philip R. Schauer

    44. Effects of Metabolic Surgery on Type 2. Diabetes

    Pia Roser, Ghassan Chamseddine, and Francesco Rubino

    45. Cardiovascular Outcomes in Metabolic Surgery

    Wen Hui Tan, Tammy Kindel, Steven Nissen, and Philip R. Schauer

    46. Effect of Bariatric Surgery on Cancer

    Justin C. Brown, Andrea M. Stroud, Priya A. Rajdev, and Bruce M. Wolfe

    47. Bariatric Surgery in Pediatric Patients

    Sarah Ogle and Thomas Inge

    48. Other Bariatric Procedures: Nerve Stimulation, Gastric Balloons, Intestinal Liners, and Others

    Cullen F. Roberts, Colston Edgerton, and Scott A. Shikora



    George A. Bray, MD, MACP, MACE, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, United States

    Claude Bouchard, PhD, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, United States

    Peter T. Katzmarzyk, PhD, FACSM, FTOS, FAHA, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, United States

    John P. Kirwan, PhD, Integrated Physiology and Molecular Medicine Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States

    Leanne M. Redman, PhD, Reproductive Endocrinology and Women’s Health Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, United States

    Philip R. Schauer, MD, Metamor Institute, Pennington Biomedical Research Center, Baton Rouge, Louisiana