5th Edition

Handbook of Obesity, Two-Volume Set

    1212 Pages 224 Color & 133 B/W Illustrations
    by CRC Press

    1212 Pages 224 Color & 133 B/W Illustrations
    by CRC Press

    This 2 volume set comprises of the 4th edition of Volume 1 and the 5th edition of Volume 2.

    The fifth edition of Volume 1 of Handbook of Obesity written by global experts covers the basic science aspects under the broad topic areas of epidemiology, etiology, and pathophysiology of obesity. Divided into 5 sections and detailed in 66 chapters, this edition covers the important advances occurring over the past decades. With a focus on science of obesity and factors participating in the etiology of obesity, this topic is studied from biological, behavioural and environmental perspectives.

    Volume 1 is structured into 5 parts:

    Part 1 focuses on the history, definitions, and prevalence of the obesity. It identifies the historical references to excess weight, obesity in art and literature, direct and surrogate measurements of adiposity and obesity related traits, epidemiology of obesity around the globe, and age, sex and ethnic variation completes this part of the volume.

    Part 2 explains the biological determinants of obesity. It explains the bioenergetics, energy dissipation mechanisms and exposure to experimental overfeeding, genetic and epigenetic evidence, metabolic rates, energy expenditure and energy partitioning, and the evidence on infections and adiposity.

    Part 3 describes the behavioral determinants of obesity. It deals with chapters related to food, beverages, and ingestive behavior, dealing with smoking, breast-feeding, and sleep duration and pattern, and sedentary behavior, occupational work, and leisure-time physical activity and obesity.

    Part 4 comprises of chapters explaining the environmental, social, and cultural determinants of obesity. The chapters in this section focus on the role of agriculture and the food industry in the current obesity epidemic, social and economic aspects of obesity, and ethnic and cultural differences and environmental pollutants.

    Part 5 of this volume discusses the health consequences of obesity. The chapters address important topics such obesity and heart disease, lipoprotein metabolism, insulin resistance and diabetes, metabolic syndrome, cancer, hepatic biology, pulmonary functions, and arthritis and gout, mental health and quality of life, growth and health disorders in pediatric populations, and on bias and discrimination affecting the obese persons.

    Volume 2 of the 5th Edition of the Handbook of Obesity spotlights on clinical applications for evaluation, diagnosis, prevention, and treatment of obesity. It covers on the several major developments occurred between the previous and the new edition, including the effect of SARS-CoV-2 on people with obesity, the concept of "Precision Medicine", and new medications approved by USFDA aiding patients with obesity weight loss of 15 to 20%.

    This volume is structured into 5 parts:

    Part 1 provides insights from evolution on changes in diet and physical activity, and the implications and results for preventing obesity, health care costs associated with obesity and the cost-effectiveness of obesity prevention and treatment.

    Part 2 deals with evaluation of overweight patients, approaches for classifying obesity and using this knowledge to evaluate patients, and addressing ethnic and racial considerations in evaluating patients with obesity.

    Part 3 explains the impact of lifestyle in managing obesity, which include behavioural management, diet, dietary composition, and meal timing, and the effects of physical activity and exercise in weight loss and weight loss maintenance.

    Part 4 is focused on medications in the management of obesity. This includes drug selection, various classes of drugs, combination of drugs affecting weight loss, effect of herbal agents on weight loss and treatment of obesity in pediatric populations, genetic diseases causing obesity and the role of drugs in treating the dyslipidemias.

    Part 5 discusses bariatric surgery, its history, procedure and effects in details, and other surgical techniques including electric stimulation of the vagus nerve, gastric balloons, intestinal liners and liposuction.

    Volume One

    Part 1 History, Definitions, and Prevalence

    Chapter 1 From Hippocrates to the Obesity Society: A Brief History
    George A. Bray and Marta Sumińska

    Chapter 2 Obesity in Art and Literature
    Fiona Haslam and David Haslam

    Chapter 3 Measurement of Total Adiposity, Regional Fat Depots, and Ectopic Fat
    Steven B. Heymsfield, Brooke Smith, and Matthew D. Robson

    Chapter 4 Anthropometric Indicators of Adiposity in Relation to the Gold Standards
    Peter T. Katzmarzyk

    Chapter 5 Worldwide and Regional Prevalence of Obesity
    Jacob C. Seidell

    Chapter 6 Age, Sex, Ethnicity, and Other Sources of Variation in the Prevalence of Obesity
    Sohyun Park and Heidi M. Blanck

    Part 2 Biological Determinants of Obesity

    Chapter 7 Bioenergetics and Obesity
    Matthew D. Lynes and Yu-Hua Tseng 

    Chapter 8 Mitochondrial Metabolic Inefficiencies in Skeletal Muscle: Implications for Obesity and Weight Loss
    Mary-Ellen Harper, Ruth McPherson, and Robert Dent

    Chapter 9 Human Experimental Overfeeding
    George A. Bray and Claude Bouchard

    Chapter 10 Biology of Calorie Restriction and Intermittent Fasting
    Leonie Heilbronn, Kai Liu, and Luigi Fontana

    Chapter 11 Genetic Epidemiology and Obesity
    Karri Silventoinen

    Chapter 12 Genetic Variation and Obesity
    Ruth J. F. Loos

    Chapter 13 Single Gene Defects and Obesity
    Héléna Mosbah, Christine Poitou, and Karine Clément

    Chapter 14 Micro and Long RNAs as Regulators in Obesity
    Jean-Francois Landrier, Flavie Sicard, and Lourdes Mounien

    Chapter 15 Epigenetics and Obesity
    Charlotte Ling and Sonia Garcia-Calzon

    Chapter 16 The Role of Adipocyte Precursors in Development and Obesity
    Tammy Ying and Rebecca A. Simmons

    Chapter 17 Small Animal Models of Obesity
    Heike Münzberg, Christopher D. Morrison, and J. Michael Salbaum

    Chapter 18 Obesity in Nonhuman Primates
    Barbara C. Hansen, Daniel Harrison, Vernon Volante, Nana Gletsu-Miller, and Kai-Lin Catherine Jen

    Chapter 19 The Transcriptome, Proteome, and Metabolome of Obesity
    Monalisa Hota, Lijin Wang, Pratap Seshachalam, and Sujoy Ghosh

    Chapter 20 CNS Regulation of Energy Balance
    Justin L. Grobe and Matthew J. Potthoff

    Chapter 21 Gastrointestinal Regulation of Energy Balance
    Timothy S. Kairupan, Nova H. Kapantow, and Akio Inui

    Chapter 22 Gut Microbiome and Obesity
    Kristina Martinez-Guryn and Eugene B. Chang

    Chapter 23 Sympathetic Nervous System and Obesity
    Elisabeth Lambert

    Chapter 24 Hypothalamic-Pituitary Hormones and Obesity
    Jonathan Q. Purnell, Mary Samuels, and Maria Fleseriu

    Chapter 25 Brown, Beige, and White Adipocyte Development
    Shingo Kajimura

    Chapter 26 Adipose Tissue Metabolism, Adipokines, and Obesity
    Ricardo J. Samms and Philipp E. Scherer

    Chapter 27 Hepatic, Visceral, Pancreatic, and Cardiac Fat Deposition
    Amalia Gastaldelli

    Chapter 28 Skeletal Muscle Metabolism and Obesity
    Polina M. Krassovskaia, Nicholas T. Broskey, and Joseph A. Houmard

    Chapter 29 Resting Metabolic Rate, Thermic Effect of Food, and Obesity
    Yves Schutz and Abdul Dulloo

    Chapter 30 Energy Cost of Exercise, Postexercise Metabolic Rates, and Obesity
    Robert Ross, Erin Miller, Emily John, and Laura Guzmán Caballero

    Chapter 31 Energy Partitioning, Substrate Oxidation Rates, and Obesity
    Angelo Tremblay, Margriet Westerterp-Plantenga, and Patrick Schrauwen
    Chapter 32 COVID-19, Other Microbial Infections, and Obesity
    Md Akheruzzaman, Vijay Hegde, and Nikhil V. Dhurandhar

    Part 3 Behavioral Determinants of Obesity

    Chapter 33 Obesity and Dietary Intake
    Eunjin Cheon, Lissa A. Davis, Vinicius M. Valicente, Yu Wang, and Richard D. Mattes

    Chapter 34 Beverages and Obesity: A Review of Current Scientific Evidence
    Miaobing Zheng, Sofus C. Larsen, Nanna J. Olsen, and Berit L. Heitmann

    Chapter 35 Obesity and Sedentary Time at Work and Home
    Stuart J.H. Biddle and Gregory J.H. Biddle

    Chapter 36 Leisure Time Physical Activity and Obesity
    Julianne G. Clina, Drew Sayer, and James O. Hill

    Chapter 37 Role of Early Life Nutrition & Breastfeeding on Obesity Development
    Maryam Kebbe, Kelsey Goynes, and Leanne M. Redman

    Chapter 38 Tobacco Use, Marijuana Use, Vaping, and Obesity
    Bernard F. Fuemmeler, Kristina L. Tatum, and D. Jeremy Barsell

    Chapter 39 Sleep and Obesity
    Silvia Cerolini and Caterina Lombardo

    Chapter 40 Eating Disorders and Obesity
    Jon M. Mond and Timothy Gill

    Part 4 Environmental, Social, and Cultural Determinants of Obesity

    Chapter 41 The Role of the Food Industry in Obesity
    Martin Binks

    Chapter 42 Transportation Policies and Obesity
    James E. Peterman and David R. Bassett, Jr.

    Chapter 43 Urban Environment and Obesity
    Katherine R. White and Lawrence D. Frank

    Chapter 44 Social and Economic Factors Related to Obesity Across the Globe
    Penny Gordon-Larsen and Pasquale E. Rummo

    Chapter 45 Influence of Culture on Obesity
    Alison Tovar, Peter T. Katzmarzyk, and Aviva Must

    Chapter 46 Environmental Chemicals and Obesity
    Sumira Phatak, Amanda S. Janesick, Thaddeus T. Schug, Jerrold J. Heindel and Bruce Blumberg

    Part 5 Consequences of Obesity

    Chapter 47 Obesity and Mortality
    Thorkild I.A. Sørensen, Justin C. Brown, and Terese Sara Høj Jørgensen

    Chapter 48 Obesity and Heart Disease
    Alexandra M. Sanchez, Nadia I. Abelhad, Andrew Elagizi, Sergey Kachur, Hector O. Ventura, and Carl J. Lavie

    Chapter 49 Obesity and Hypertension
    John E. Hall, Ana C. M. Omoto, Jussara M. do Carmo, Alexandre A. da Silva, Zhen Wang, Alan Mouton, Xuan Li, and Michael E. Hall

    Chapter 50 Obesity and Lipoprotein Metabolism
    Sally Chiu and Ronald M. Krauss

    Chapter 51 Obesity and Insulin Resistance
    John P. Kirwan and Christopher L. Axelrod

    Chapter 52 Obesity and Type 2 Diabetes
    Norbert Stefan

    Chapter 53 Obesity and Metabolic Syndrome
    André Tchernof and Jean-Pierre Després

    Chapter 54 Obesity and Cancer
    Alpa V. Patel and Lauren R. Teras

    Chapter 55 Obesity and Inflammation
    Sierra Nance, Ramiah Jacks, and Carey Lumeng

    Chapter 56 Obesity, Gallbladder, and Gastrointestinal Diseases
    Michael Camilleri and Andres Acosta

    Chapter 57 Obesity and Liver Diseases
    Münevver Demir, Josephine Frohme, and Frank Tacke

    Chapter 58 Obesity, Lung Function, and Lung Disease
    Anne E. Dixon and Swati A. Bhatawadekar

    Chapter 59 Obesity and Gout
    Lorraine Watson and Edward Roddy

    Chapter 60 Obesity, Osteoarthritis, and Bone Disorders
    Sanjay Mediwala and Dennis T. Villareal

    Chapter 61 Obesity and Cognitive Decline
    Adam Tabak, Vince Fazekas-Pongor, Stefano Tarantini, Priya Balasubramanian, Anna Csiszar and Zoltan Ungvari

    Chapter 62 Obesity, Mental Health, and Health-related Quality of Life
    Osnat C. Melamed, Peter Selby, and Valerie H. Taylor

    Chapter 63 Obesity and Reproductive Dysfunction
    Ronald Swerdloff, Waleed Butt, and Christina Wang

    Chapter 64 Obesity in Pregnancy Complications and Outcomes
    Amy M. Valent and Aaron B. Caughey

    Chapter 65 Obesity, Growth, Development, Metabolic Disorder, and Insulin Resistance in Pediatrics
    Nicola Santoro, Alfonso Galderisi, and Sonia Caprio

    Chapter 66 Bias, Discrimination, and Obesity
    Rebecca M. Puhl


    Volume Two

    Part 1 Prevention and Economic Outcomes of Obesity
    Chapter 1 Dietary Changes in Human Evolution: Implications for the Prevention of Obesity
    Peter Andrews and Richard Johnson

    Chapter 2 Evolutionary Changes in Physical Activity, Diet, and Energy Expenditure: Implications for the Prevention of Obesity
    Herman Pontzer

    Chapter 3 Prevention of Obesity in Adults
    Suzanne Phelan

    Chapter 4 The Prevention of Obesity in Children and Adolescents
    Tim Lobstein and Louise Baur

    Chapter 5 Re-engineering the Built Environment: Progress in Schools, Worksites, Neighborhoods, and Communities
    Stephanie T. Broyles and Maura M. Kepper

    Chapter 6 The Economic Costs of Obesity
    Adam Biener, John Cawley, and Chad Meyerhoefer

    Chapter 7 Cost-effectiveness of Obesity Prevention and Treatment
    Jaithri Ananthapavan, Marj Moodie, and Victoria Brown

    Chapter 8 Role of Government and Non-Government Organizations in the Obesity Pandemic and Its Prevention
    Simon Barquera, Mariel White, Gabriela Argumedo, Carolina Batis, and Juan Rivera-Dommarco

    Chapter 9 Role of Reimbursement in the Delivery of Treatment for Obesity in Adults and Children
    Chika Vera Anekwe, Veronica R. Johnson, Matthew J. Townsend, and Fatima Cody Stanford

    Part 2 Evaluation of the Patients with Overweight or Obesity

    Chapter 10 Classification, Evaluation, and Staging of the Patient with Obesity
    Robert F. Kushner and Amanda Velazquez

    Chapter 11 Indicators of Central Adiposity: A Critical Evaluation of Their Usefulness
    Ian J. Neeland, Jean-Pierre Després, André C. Carpentier, and Paul Poirier

    Chapter 12 Genetic Obesity Syndromes
    I. Sadaf Farooqi and Stephen O'Rahilly

    Chapter 13 Ethnic and Racial Considerations in the Evaluation of the Patient with Obesity
    Peter T. Katzmarzyk, Sean Wharton, Fatima Cody Stanford, and Daniel G. Aaron

    Part 3 Lifestyle in the Management of Obesity: Behavioral Modification, Diet, and Exercise

    Chapter 14 Best Practices: Obesity and the Primary Care Providers
    Christine Gallagher, Donna H. Ryan, and William Dietz

    Chapter 15 In-person Behavioral Approaches for Weight Management
    Jena S. Tronieri and Thomas A. Wadden

    Chapter 16 Behavioral Interventions Delivered Remotely
    Christoph Höchsmann and Corby K. Martin

    Chapter 17 Cultural Considerations in Behavioral Therapy for Management of Obesity
    Robert L. Newton, Jr., Elva Arredondo, Patricia Dionicio, and Noe C. Crespo

    Chapter 18 Diet Composition and Weight Loss: Is a Calorie a Calorie?
    Kevin D. Hall

    Chapter 19 Circadian Rhythms and Weight Loss: Timed Food Intake
    Emily N. C. Manoogian, Nikko R. Gutierrez, Erika Padilla, and Michael J. Wilkinson

    Chapter 20 Comparison of Modern-Millennial Diets
    Monica Dinu, Daniela Martini, Francesco Sofi, Mauro Serafini, Marisa Porrini, and Donato Angelino

    Chapter 21 Dietary Energy Density and Its Contribution to Weight Control
    Faris M. Zuraikat and Barbara J. Rolls

    Chapter 22 Dietary Patterns as a Basis for Diet Selection
    Catherine Champagne

    Chapter 23 Physical Activity and Weight Loss: Volume, Intensity, and Mode
    John M. Jakicic and Renee J. Rogers

    Chapter 24 Modifying Sedentary Behavior for the Prevention and Treatment of Obesity  
    Bethany Barone Gibbs

    Chapter 25 Preventing Weight Regain After Weight Loss
    Stephen D. Anton and Michael G. Perri

    Chapter 26 Personalized and Precision Nutrition in the Management of Obesity: Can We Tailor the Treatment to the Patient?
    George Thom and Mike Lean

    Part 4 Medications in the Management of Obesity

    Chapter 27 Drug-associated Weight Gain and Clinical Alternatives
    Barbara Ameer and Michael A. Weintraub

    Chapter 28 Mechanisms of Drug Action in Obesity
    M. Furkan Burak, Nawfal W. Istfan, and Caroline M. Apovian

    Chapter 29 Metabolic Effects of Progressive Weight Loss
    Faidon Magkos

    Chapter 30 Older Drugs Used to Manage Obesity: Sympathomimetics and Orlistat
    Frank L. Greenway and George A. Bray

    Chapter 31 Serotonergic Drugs for Treating Obesity
    Mireille J. Serlie

    Chapter 32 Antidiabetic Drugs that Reduce Weight and Are Cardioprotective
    Carolina M. Perdomo, Javier Escalada, and Gema Frühbeck

    Chapter 33 Approved Combination Agents: Phentermine/Topiramate
    W. Timothy Garvey

    Chapter 34 Approved Combination Agents: Naltrexone-Bupropion
    Igho J. Onakpoya and Carl J. Heneghan

    Chapter 35 Drugs That Affect Body Weight: The Glucagon-like Peptide-1 Agonists
    Randa Ghazal-Asswad and John P.H. Wilding

    Chapter 36 Hydrogels in the Treatment of Obesity
    Frank L. Greenway

    Chapter 37 Dual and Triple-Action Peptides
    Thinzar Min and Stephen C. Bain

    Chapter 38 Antiobesity Medications on the Horizon
    Sarah R. Barenbaum and Louis J. Aronne

    Chapter 39 Treatments for Rare Forms of Genetic Obesity
    Joan C. Han, Nandini Basuray, and Andrea M. Haqq

    Chapter 40 Special Issues in Using Medications in Children & Adolescents
    Jaime M. Moore, Stephen R. Daniels, and Claudia K. Fox
    Chapter 41 Dietary Supplements and Weight Management
    Carol J. Haggans, Rebecca B. Costello, Leila G. Saldanha, Abby G. Ershow, and William T. Cefalu

    Part 5 Surgical Interventions for Obesity

    Chapter 42 Historical Overview of Metabolic and Bariatric Surgery
    Henry Buchwald

    Chapter 43 Overview: Current Metabolic Operations and Long-term Outcomes
    Robert C. Ross, Vance L. Albaugh, Ali Aminian, and Philip R. Schauer

    Chapter 44 Effects of Metabolic Surgery on Type 2 Diabetes
    Pia Roser, Ghassan Chamseddine, and Francesco Rubino

    Chapter 45 Cardiovascular Outcomes in Metabolic Surgery
    Wen Hui Tan, Tammy Kindel, Steven Nissen, and Philip R. Schauer

    Chapter 46 Effect of Bariatric Surgery on Cancer
    Justin C. Brown, Andrea M. Stroud, Priya A. Rajdev, and Bruce M. Wolfe

    Chapter 47 Bariatric Surgery in Pediatric Patients
    Sarah Ogle and Thomas Inge

    Chapter 48 Other Bariatric Procedures: Nerve Stimulation, Gastric Balloons, Intestinal Liners, and Others
    Cullen F. Roberts, Colston Edgerton, and Scott A. Shikora


    George A. Bray, MD, MACP, MACE, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, United States

    Claude Bouchard, PhD, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, United States

    Peter T. Katzmarzyk, PhD, FACSM, FTOS, FAHA, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, United States

    John P. Kirwan, PhD, Integrated Physiology and Molecular Medicine Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States

    Leanne M. Redman, PhD, Reproductive Endocrinology and Women’s Health Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, United States

    Philip R. Schauer, MD, Metamor Institute, Pennington Biomedical Research Center, Baton Rouge, Louisiana