Handbook of Opioid Bowel Syndrome

• About the Editor
  
• Contributors
  
• Preface
  
• Introduction (Chun-Su Yuan and Marco Pappagallo)
  
• SECTION I: BASIC CONCEPTS IN OPIOID BOWEL DYSFUNCTION
  
• Chapter 1. Gastrointestinal Opioid Physiology and Pharmacology (Keri L. Fakata and Arthur G. Lipman)
  
• Gastrointestinal Physiology
  
• Opioid Effects on the Gastrointestinal System
  
• Exogenous Opioid Effects on the Gastrointestinal System
  
• Chapter 2. Pathophysiology of Opioid-Induced Bowel Dysfunction (Sangeeta R. Mehendale and Chun-Su Yuan)
  
• Gastrointestinal Dysfunction Caused by Exogenous Opioids
  
• Role of Endogenous Opioids in Normal and Impaired Gut Function
  
• Chapter 3. Opioid-Induced Immunosuppression (Gang Wei, Jonathan Moss, and Chun-Su Yuan)
  
• Studies of Opioid-Induced Immunosuppression
  
• Is Opioid-Induced Immunosuppression Centrally Mediated?
  
• Is Opioid-Induced Immunosuppression Peripherally Mediated?
  
• Summary and Future Work
  
• SECTION II: CLINICAL STATES
  
• Chapter 4. The Epidemiology of Opioid Bowel Dysfunction (Ysmael Yap and Marco Pappagallo)
  
• Introduction
  
• Gastrointestinal Adverse Effects of Opioids
  
• Prevalence in the General Population
  
• Prevalence in the Opioid-Treated Population
  
• Discussion
  
• Chapter 5. Opioid Bowel Dysfunction in Palliative Care (Nigel P. Sykes)
  
• Introduction
  
• Constipation
  
• Evaluation of Constipation
  
• Management
  
• Nausea and Vomiting
  
• Conclusion
  
• Chapter 6. Opioid Bowel Dysfunction in Acute and Chronic Nonmalignant Pain (Keri L. Fakata, Ashok K. Tuteja, and Arthur G. Lipman)
  
• Introduction
  
• Differentiating Pain Types
  
• Opioid Bowel Dysfunction in Acute Pain
  
• Opioid Bowel Dysfunction in Chronic Nonmalignant Pain
  
• Is Opioid Bowel Dysfunction Properly Addressed in These Populations?
  
• Current Treatment Options for Opioid Bowel Dysfunction
  
• Conclusion
  
• Chapter 7. Postoperative Bowel Dysfunction (Cormac Fahy and Tong J. Gan)
  
• Introduction
  
• Pathogenesis of Postoperative Ileus
  
• Contribution of Perioperative and Postoperative Opioids
  
• Role of General Anesthesia in Postoperative Bowel Dysfunction
  
• Therapy of Postoperative Bowel Dysfunction
  
• Conclusions
  
• Chapter 8. Postsurgical Bowel Dysfunction in the Gynecologic Patient (Eric J. Bieber)
  
• Introduction
  
• Pathophysiology
  
• Bowel Function After Hysterectomy
  
• Effect of Early Feedings and NG Use on Bowel Function
  
• Epidurals, General Anesthesia, and Patient-Controlled Analgesia
  
• Opioid Antagonists
  
• Conclusion
  
• SECTION III: ADVANCES IN TREATING OPIOID BOWEL DYSFUNCTION
  
• Chapter 9. Using Oral Naloxone in Management of Opioid Bowel Dysfunction (Nigel P. Sykes)
  
• Evidence for a Peripheral Site of Opioid Constipating Action
  
• Naloxone As an Opioid Antagonist
  
• The Use of Naloxone for Treatment of Opioid-Induced Constipation
  
• Discussion of Reported Clinical Studies
  
• Use of Oral Naloxone for Idiopathic Constipation
  
• Discussion of Reported Studies of Naloxone for Idiopathic Constipation
  
• Chapter 10. Methylnaltrexone: Investigations in Treating Opioid Bowel Dysfunction (Thomas A. Boyd and Chun-Su Yuan)
  
• Receptor-Binding Studies
  
• Preclinical Studies
  
• Absorption, Elimination, and Metabolism
  
• Safety and Tolerance Studies in Humans
  
• Efficacy Studies
  
• Summary
  
• Chapter 11. Management of Opioid-Induced Bowel Dysfunction and Postoperative Ileus: Potential Role of Alvimopan (Joseph F. Foss and William K. Schmidt)
  
• Introduction
  
• Preclinical Development
  
• Clinical Development
  
• Summary
  
• Index
  
• Reference Notes Included
  

Biography

Editor: Chun-Su Yuan, MD, PhD, is the Cyrus Tang Professor in the Department of Anesthesia & Critical Care at the Pritzker School of Medicine, University of Chicago. Since 1994, Dr.Yuan has been conducting clinical trials evaluating the safety and efficacy of a novel peripheral opioid receptor antagonist, methylnaltrexone, for reversing opioid-induced bowel dysfunction. He has published over 150 research papers, including many articles on opioid action and antagonism of opioid side effects.