Handbook of Personalized Medicine
Advances in Nanotechnology, Drug Delivery, and Therapy
Preview
Book Description
This book compiles multidisciplinary efforts to conceptualize the environment in research and clinical setting that creates the fertile ground for the practical utility of personalized medicine decisions and also enables clinical pharmacogenomics for establishing pharmacotyping in drug prescription. Its covers innovative drug formulations and nanotheranostics, molecular imaging and signatures, translational nanomedicine and informatics, stem cell therapy approaches, modeling and predictability of drug response, pharmacogenetics-guided drug prescription, pediatric drug dosing, pharmacovigilance and regulatory aspects, ethical and cost-effectiveness issues, pharmacogenomics knowledge bases, personal genome sequencing, molecular diagnostics, as well as information-based medicine.
Table of Contents
Implementation of pharmacogenetics in evidence-based medicine
Pharmacotyping-based drug prescription
Pharmacogenetics-guided antithrombotic therapy
Translational bioinformatics and systems biology
Predictive genomic signatures
Personalizing stem cell therapeutic potential
RNAi nanomedicines
Nanotechnology advancements for personalized medicine
Pharmacogenetics and pharmacovigilance
Genetic variability of cytochrome P450 drug metabolizing enzymes
Developmental Pharmacology and Pediatric Drug Dosing
Functional mapping of drug response
Predictive molecular signatures
Information-based medicine
Simcyp population-based ADME simulator
The Coriell personalized medicine collaborative
Drug bioavailability and gene profiling
Safety assessment in nanotechnology
In vivo pharmacology
Biostatistics and text mining
Intersection of pharmacology, imaging, and genetics
Boron Neutron Capture Therapy
Personalized medicine in breast cancer
Personalized therapy of metabolic diseases
Molecular biomarkers and imaging
Pharmacogenomics of drug-induced hepatotoxicity
Education programs for pharmacogenomics
Computerized clinical decision support systems for prescribing
Therapeutic drug monitoring
Cost-effectiveness of pharmacogenomics
Ethical and legal pharmacogenomics issues
Reviews
The development of the Handbook of Personalized Medicine is timely. Medicine and health have evidently moved on and continue to progress and develop at a pace. Gone are the days, perhaps, when medical treatments for patients were developed and designed as a ‘one size fits all’ solution. Much more is now understood about individual differences in the way in which diseases develop and specifically also about individual differences in response to treatments. ... This book represents an exceedingly comprehensive and detailed account of these developments, with the aim of integrating certain of these approaches into every day clinical practice. ... its structure is clearly laid out, contributing authors clearly stated and the periodic use of comprehensive tables, graphs, and colour figures undoubtedly improve its understanding. ... This book has been a massive undertaking to produce and portrays a journey from the most basic considerations through to the medical practice of the future."
—David Fishwick, Occupational Medicine Journal