1st Edition

Handbook of Personalized Medicine Advances in Nanotechnology, Drug Delivery, and Therapy

Edited By Ioannis S. Vizirianakis Copyright 2013
    1560 Pages 48 Color & 88 B/W Illustrations
    by Jenny Stanford Publishing

    This book compiles multidisciplinary efforts to conceptualize the environment in research and clinical setting that creates the fertile ground for the practical utility of personalized medicine decisions and also enables clinical pharmacogenomics for establishing pharmacotyping in drug prescription. Its covers innovative drug formulations and nanotheranostics, molecular imaging and signatures, translational nanomedicine and informatics, stem cell therapy approaches, modeling and predictability of drug response, pharmacogenetics-guided drug prescription, pediatric drug dosing, pharmacovigilance and regulatory aspects, ethical and cost-effectiveness issues, pharmacogenomics knowledge bases, personal genome sequencing, molecular diagnostics, as well as information-based medicine.

    Implementation of pharmacogenetics in evidence-based medicine
    Pharmacotyping-based drug prescription
    Pharmacogenetics-guided antithrombotic therapy
    Translational bioinformatics and systems biology
    Predictive genomic signatures
    Personalizing stem cell therapeutic potential
    RNAi nanomedicines
    Nanotechnology advancements for personalized medicine
    Pharmacogenetics and pharmacovigilance
    Genetic variability of cytochrome P450 drug metabolizing enzymes
    Developmental Pharmacology and Pediatric Drug Dosing
    Functional mapping of drug response
    Predictive molecular signatures
    Information-based medicine
    Simcyp population-based ADME simulator
    The Coriell personalized medicine collaborative
    Drug bioavailability and gene profiling
    Safety assessment in nanotechnology
    In vivo pharmacology
    Biostatistics and text mining
    Intersection of pharmacology, imaging, and genetics
    Boron Neutron Capture Therapy
    Personalized medicine in breast cancer
    Personalized therapy of metabolic diseases
    Molecular biomarkers and imaging
    Pharmacogenomics of drug-induced hepatotoxicity
    Education programs for pharmacogenomics
    Computerized clinical decision support systems for prescribing
    Therapeutic drug monitoring
    Cost-effectiveness of pharmacogenomics
    Ethical and legal pharmacogenomics issues


    Ioannis S. Vizirianakis

    The development of the Handbook of Personalized Medicine is timely. Medicine and health have evidently moved on and continue to progress and develop at a pace. Gone are the days, perhaps, when medical treatments for patients were developed and designed as a ‘one size fits all’ solution. Much more is now understood about individual differences in the way in which diseases develop and specifically also about individual differences in response to treatments. ... This book represents an exceedingly comprehensive and detailed account of these developments, with the aim of integrating certain of these approaches into every day clinical practice. ... its structure is clearly laid out, contributing authors clearly stated and the periodic use of comprehensive tables, graphs, and colour figures undoubtedly improve its understanding. ... This book has been a massive undertaking to produce and portrays a journey from the most basic considerations through to the medical practice of the future."
    David Fishwick, Occupational Medicine Journal