1st Edition

Handbook of Pharmaceutical Controlled Release Technology

By Donald L. Wise Copyright 2000

    The Handbook of Pharmaceutical Controlled Release Technology reviews the design, fabrication, methodology, administration, and classifications of various drug delivery systems, including matrices, and membrane controlled reservoir, bioerodible, and pendant chain systems.
    Contains cutting-edge research on the controlled delivery of biomolecules!
    Discussing the advantages and limitations of controlled release systems, the Handbook of Pharmaceutical Controlled Release Technology

  • covers oral, transdermal, parenteral, and implantable delivery of drugs
  • discusses modification methods to achieve desired release kinetics
  • highlights constraints of system design for practical clinical application
  • analyzes diffusion equations and mathematical modeling
  • considers environmental acceptance and tissue compatibility of biopolymeric systems for biologically active agents
  • evaluates polymers as drug delivery carriers
  • describes peptide, protein, micro-, and nanoparticulate release systems
  • examines the cost, comfort, disease control, side effects, and patient compliance of numerous delivery systems and devices
  • and more!
  • Polymers as Drug Delivery Carriers

    Hydrophilic Cellulose Derivatives as Drug Delivery Carriers: Influence of Substitution Type on the Properties of Compressed Matrix Tablets,
    Carmen Ferrero Rodriguez, Nathalie Bruneau, Jérôme Barra, Dorothée Alfonso, and Eric Doelker
    Poly(Vinyl Alcohol) as a Drug Delivery Carrier, Surya K. Mallapragada and Shannon McCarthy-Schroeder
    Development of Acrylate and Methacrylate Polymer Networks for Controlled Release by Photopolymerization Technology,
    Robert Scott, Jennifer H. Ward, and Nicholas A. Peppas
    Smart Polymers for Controlled Drug Delivery,
    Joseph Kost and Smadar A. Lapidot
    Complexing Polymers in Drug Delivery,
    Anthony M. Lowman
    Polylactic and Polyglycolic Acids as Drug Delivery Carriers,
    Lisa Brannon-Peppas and Michel Vert
    Use of Infrared and Raman Spectroscopy for Characterization of Controlled Release Systems,
    A. B. Scranton, B. Drescher, E. W. Nelson, and J. L. Jacobs
    Accurate Models in Controlled Drug Delivery Systems,
    Balaji Narasimhan

    Mechanism-Based Classification of Controlled Release Devices

    Drug Release from Swelling-Controlled Systems,
    Paolo Colombo, Patrizia Santi, Ruggero Bettini,Christopher S. Brazel, and Nikolaos A. Peppas
    Superporous Hydrogels as a Platform for Oral Controlled Drug Delivery,
    Haesun Park, Jun Chen, and Kinam Park
    Osmotic Implantable Delivery Systems,
    Jeremy C. Wright, Felix Theeuwes, and Cynthia L. Stevenson
    Bioadhesive Controlled Release Systems,
    Nicholas A. Peppas, Monica D. Little, and Yanbin Huang

    Micro- and Nanoparticulate Release Systems

    Microencapsulation Technology: Interfacial Polymerization Method,
    A. Atïla Hincal and H. Süheyla Kas
    Nanoparticulate Controlled Release Systems for Cancer Therapy,
    C. Dubernet, E. Fattal, and P. Couvreur
    Microencapsulation Using Coacervation/Phase Separation: An Overview of the Technique and Applications,
    H. Süheyla Kas and Levent Öner
    Microsphere Preparation by Solvent Evaporation Method,
    A. Atïla Hincal and Sema Calis
    Nanosuspensions-A Formulation Approach for Poorly Soluble and Poorly Bioavailable Drugs, R. H. Müller, B. H. L. Bohm, and M. J. Grau
    Large-Scale Production of Solid Lipid Nanoparticles (SLN) and Nanosuspensions (DissoCubes),
    R. H. Müller, S. Gohla, A. Dingler, and T. Schneppe
    Solid Lipid Nanoparticles (SLN) as a Carrier System for the Controlled Release of Drugs,
    R. H. Müller, A. Lippacher, and S. Gohla
    Stability of Encapsulated Substances in Poly(Lactide-co-Glycolide) Delivery Systems,
    Steven P. Schwendeman, Gaozhong Zhu, Anna Shenderova, and Wenle Jiang
    Development of Polysaccharides as Novel Drug Carrier Systems,
    C. Vauthier and P. Couvreur

    Classification of Controlled Release Devices According to Administration Site

    An Overview of Controlled Release Systems,
    S. Venkatraman, N. Davar, A. Chester, and L. Kleiner
    Research and Development Aspects of Oral Controlled-Release Dosage Forms,
    Yihong Qiu and Guohua Zhang
    A Gastrointestinal Retentive Microparticulate System to Improve Oral Drug Delivery,
    Y. Kawashima, H. Takeuchi, and H. Yamamoto
    In Vitro-In Vivo Correlations in the Development of Solid Oral Controlled Release Dosage Forms,
    Yihong Qiu, Emil E. Samara, and Guoliang Cao
    Gamma Scintigraphy in the Analysis of the Behavior of Controlled Release Systems,
    C. G. Wilson and N. Washington
    Electrically Assisted Transdermal Delivery of Drugs,
    Ajay K. Banga
    A Novel Method Based on Artificial Neural Networks for Optimizing Transdermal Drug Delivery Systems,
    Kozo Takayama and Tsuneji Nagai
    Transdermal Drug Delivery by Skin Electroporation,
    Tani Chen, Robert Langer, and James C. Weaver
    Enhancement of Transdermal Transport Using Ultrasound in Combination with Other Enhancers,
    Joseph Kost, Samir Mitragotri, and Robert Langer
    Electrotransport Systems for Transdermal Delivery: A Practical Implementation of Iontophoresis,
    Erik R. Scott, J. Bradley Phipps, J. Richard Gyory, and Rama V. Padmanabhan
    Peptide and Protein Release Systems

    Controlled Release Protein Therapeutics: Effects of Process and Formulation on Stability,
    Paul A. Burke
    Solid-State Chemical Stability of Peptides and Proteins: Application to Controlled Release Formulations,
    Elizabeth M. Topp, Yuan Song, Ashley Wilson, Rong Li, Michael J. Hageman, and Richard L. Schowen
    Growth Factor Release from Biodegradable Hydrogels to Induce Neovascularization,
    Yoshita Ikada and Yasuhiko Tabata
    Biopolymers for Release of Interleukin-2 for Treatment of Cancer, Debra J. Trantolo, Joseph D. Gresser, A. Ganiyu Jimoh, Donald L. Wise,and James C. Yang

    Medical Applications of Drug Delivery

    Osmotic Drug Delivery from Asymmetric Membrane Film-Coated Dosage Forms,
    Mary Tanya am Ende, Scott M. Herbig, Richard W. Korsmeyer, and Mark B. Chidlaw
    Controlled Release Pain Management Systems,
    Vasif Hasirci, Dilek Sendil, Leonidas C. Goudas, Daniel B. Carr, and Donald L. Wise
    Biodegradable Systems for Long-Acting Nestorone,
    Debra J. Trantolo, Donald L. Wise, A. J. Moo-Young, Yung-Yueh Hsu, and Joseph D. Gresser
    Preparation and Evaluation of Buprenorphine Microspheres for Parenteral Administration,
    William R. Ravis, Yuh-Jing Lin, and Ram Murty
    Prolonged Release of Hydromorphone from a Novel Poly(Lactic-co-Glycolic) Acid Depot System: Initial In Vitro and In Vivo Observations,
    Leonidas C. Goudas, Daniel B. Carr, Richard M. Kream, Louis Shuster, William M. Vaughan, Joseph D. Gresser,Donald L. Wise, and Debra J. Trantolo
    Incorporation of an Active Agent into a Biodegradable Cement: Encapsulation of the Agent as Protection from Chemical Degradation During Cure and Effect on Release Profile,
    Joseph D. Gresser, Debra J. Trantolo, Pattisapu R. J. Gangadharam, Hisanori X. Nagaoka,Yung-Yueh Hsu, and Donald L. Wise
    The Pharmacoeconomic Value of Controlled Release Dosage Forms,
    Laura B. Gardner


    Donald L. Wise

    ...provide[s] informative reference sources.
    "-Pharmaceutical Research