Handbook of Pharmacokinetics and Toxicokinetics  book cover
2nd Edition

Handbook of Pharmacokinetics and Toxicokinetics

  • Available for pre-order on June 7, 2023. Item will ship after June 28, 2023
ISBN 9781032197050
June 28, 2023 Forthcoming by CRC Press
640 Pages 224 B/W Illustrations

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USD $220.00

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Book Description

The fully revised and expanded volume is an effort to blend the common approaches to pharmacokinetics and toxicokinetics. It integrates the principles held in common by both fields through a logical and systematic approach, which includes mathematical descriptions of physical and physiological processes employed in approaches to PK/TK modeling. It emphasizes general principles and concepts and related isolated applications and case studies observations.The systematic compilation of mathematical concepts and methodologies allows readers to decide on relevant concepts and approaches for their research, scientific or regulatory decisions, or for offering advance courses/workshops and seminars.

Selling Points:

  • Comprehensive handbook on principles and applications of PK/TK appealing to a diverse audience including scientists and students.
  •  An excellent text fully revised and fully updated for anyone interested in the theoretical and practical pharmacokinetics.
  • The systematic compilation of mathematical concepts and methodologies allows readers to decide on relevant concepts and approaches for their research.
  •  Incorporates research relevant to SDGs and of interest to industrial and regulatory environmental scientists involved in chemical contamination research and regulatory decision making related to soil, water, and ocean.
  • Includes sections on applications and case studies.

Table of Contents

Chapter 1. Pharmacokinetics and Toxicokinetics. Chapter 2. PK-TK Conisderations of Auricular (Optic) - Buccal/Sublingual and Ocular/Ophthalmic Routes of Administration. Chapter 3. PK-TK Considerations of Nasal, Pulmonary and Oral Routes of Administration. Chapter 4. PK-TK Considerations of Intraarterial - Intramuscular Intraperitoneal - Intravenous - and Subcutaneous Routes of Administration. Chapter 5. PK-TK Considerations of Transdermal - Intradermal - and Intraepidermal Routes of Administration. Chapter 6. PK-TK Considerations of Rectal - Vaginal - Intraovarian Routes of Administration. Chapter 7. PK-TK Considerations of Absorption Mechanisms and Rate Equations. Chapter 8. PK-TK Considerations of Distribution Mechanisms and Rate Equations. Chapter 8. PK-TK Considerations of Metabolism Biotransformation of Xenobiotics Mechanisms and Rate Equations. Chapter 10. PK-TK Considerations of Renal Function and Elimination of Xenobiotics Estimation of Parameters and Constants. Chapter 11. Elimination Rates & Clearances (Excretion + Metabolism). Chapter 12. Approaches in PK-PD and TK-TD Mathematical Modeling. Chapter 13. Practical Applications of PK/TK Models Instantaneous Exposure to Xenobiotics Single Intravenous Bolus Injection. Chapter 14. Practical Applications of PK/TK Models Continuous Zero-Order Exposure to Xenobiotics Intravenous Infusion. Chapter 15. Practical Applications of PK/TK Models First-order Absorption via Extravascular Routes Oral Administration. Chapter 16. Practical Application of PK/TK Models Multiple Dosing Kinetics. Chapter 17. Biopharmaceutics Provisions, Dynamics, and Classifications Mechanistic Absorption Models. Chapter 18. Bioavailability, Bioequivalence and Biosimilarity. Chapter 19. Quantitative Extrapolations Cross-Species Extrapolation Low-Dose Extrapolation. Chapter 20. Practical Application of PK/TK Models Population Pharmacokinetics/Toxicokinetics. Chapter 21. Practical Application of PK/TK Models Preclinical PK/TK and Clinical Trials. Chapter 22. Adjustment of Dosage Regimen Renal Impairment, Liver Diseases, Pregnancy.

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Mehdi Boroujerdi is a pharmaceutics and pharmacokinetics/toxicokinetic research and teaching consultant. He previously served as a professor of pharmaceutics and pharmacokinetics at Northeastern University, Boston, MA; University of MCPHS, College of Pharmacy, Boston, MA; Professor of Pharmacokinetics at Albany College of Pharmacy and Health Sciences, Albany, NY; and professor of pharmaceutical sciences at the University of Massachusetts, Lowell. He also served as the dean for all the above colleges and provost at ACPHS. He earned his PhD in pharmaceutics and pharmacokinetics from the University of North Carolina at Chapel Hill and conducted postdoctoral research at the National Institute of Health – National Institute of Environmental Health Sciences in chemical carcinogenesis and low dose extrapolation of carcinogens. Dr. Boroujerdi has a broad background and experience in pharmacokinetics/toxicokinetics research and education. He has published more than 110 peer-reviewed articles as well as two books on pharmacokinetics; and has trained numerous post-docs and graduate undergraduate students in research areas related to PK/PD and TK/TD.