Handbook of Physics in Medicine and Biology: 1st Edition (Hardback) book cover

Handbook of Physics in Medicine and Biology

1st Edition

Edited by Robert Splinter

CRC Press

548 pages | 565 B/W Illus.

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Hardback: 9781420075243
pub: 2010-04-05
eBook (VitalSource) : 9780429193064
pub: 2010-04-05
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In considering ways that physics has helped advance biology and medicine, what typically comes to mind are the various tools used by researchers and clinicians. We think of the optics put to work in microscopes, endoscopes, and lasers; the advanced diagnostics permitted through magnetic, x-ray, and ultrasound imaging; and even the nanotools, that allow us to tinker with molecules. We build these instruments in accordance with the closest thing to absolute truths we know, the laws of physics, but seldom do we apply those same constants of physics to the study of our own carbon-based beings, such as fluidics applied to the flow of blood, or the laws of motion and energy applied to working muscle.

Instead of considering one aspect or the other,Handbook of Physics in Medicine and Biology explores the full gamut of physics’ relationship to biology and medicine in more than 40 chapters, written by experts from the lab to the clinic.

The book begins with a basic description of specific biological features and delves into the physics of explicit anatomical structures starting with the cell. Later chapters look at the body's senses, organs, and systems, continuing to explain biological functions in the language of physics.

The text then details various analytical modalities such as imaging and diagnostic methods. A final section turns to future perspectives related to tissue engineering, including the biophysics of prostheses and regenerative medicine.

The editor’s approach throughout is to address the major healthcare challenges, including tissue engineering and reproductive medicine, as well as development of artificial organs and prosthetic devices. The contents are organized by organ type and biological function, which is given a clear description in terms of electric, mechanical, thermodynamic, and hydrodynamic properties. In addition to the physical descriptions, each chapter discusses principles of related clinical diagnostic methods and technological aspects of therapeutic applications. The final section on regenerative engineering, emphasizes biochemical and physiochemical factors that are important to improving or replacing biological functions. Chapters cover materials used for a broad range of applications associated with the replacement or repair of tissues or entire tissue structures.


The handbook includes hundreds of diagrams, images and tables, making it a useful tool for both medical physicists/engineers and other medical/biology specialists … includes materials that are rarely combined together, which strengthens its interdisciplinary approach.

Physics in Medicine and Biology, 55 (2010)

My deep impression is this is an excellent work by a highly competent team. The book chapters follow logically from the properties of the cell membrane through sensors and electroreception, biomechanics and fluid dynamics to the recording of bioelectrical signals, bioelectric impedence analysis, x-ray and computed tomography, magnetic resonance imaging, nuclear medicine, ultrasonic and thermographic imaging … keep this book close at hand and do not hesitate to use it frequently.

BioMedical Engineering OnLine, 2010

Table of Contents


1 Physics of the Cell Membrane, Thomas Wolkow

2 Protein Signaling, Sonja Braun-Sand

3 Cell Biology and Biophysics of the Cell Membrane, Didier Dreau

4 Cellular Termodynamics, Pavlina Pike

5 Action Potential Transmission and Volume Conduction, Robert Splinter


6 Medical Decision Making, Robert Splinter

7 Senses, Robert Splinter

8 Somatic Senses: Touch and Pain, Jean-Marc Aimonetti and Sasa Radovanovic

9 Hearing, Mark S. Hedrick

10 Vision, Hiroto Ishikawa, Naohiro Ikeda, Sanae Kanno, Tomohiro Ikeda, Osamu Mimura, and Mari Dezawa

11 Electroreception, Robert Splinter


12 Biomechanics, Robert Splinter

13 Artifi cial Muscle, Robert Splinter and Paul Elliott

14 Cardiovascular System, Istvan Osztheimer

15 Control of Cardiac Output and Arterial Blood Pressure Regulation, Istvan Osztheimer and Pal Maurovich

16 Fluid Dynamics of the Cardiovascular System, Aurélien F. Stalder and Michael Markl

17 Fluid Dynamics, Takuji Ishikawa

18 Modeling and Simulation of the Cardiovascular System to Determine Work Using Bond Graphs, Paola Garcia

19 Anatomy and Physics of Respiration, Tim Moss, Jane Pillow, and David Baldwin


20 Electrodes, Rossana E. Madrid, Ernesto F. Treo, Myriam C. Herrera, and Carmen C. Mayorga Martínez

21 Recording of Bioelectrical Signals: Theory and Practice, Juha Voipio


22 Medical Sensing and Imaging, Robert Splinter

23 Electrocardiogram: Electrical Information Retrieval and Diagnostics from the Beating Heart, Orsolya Kiss

24 Electroencephalography: Basic Concepts and Brain Applications, Jodie R. Gawryluk and Ryan C.N. D’Arcy

25 Bioelectric Impedance Analysis, A.V. Smirnov, D.V. Nikolaev, and S.G. Rudnev

26 X-Ray and Computed Tomography, Ravi Chityala

27 Confocal Microscopy, Robert Splinter

28 Magnetic Resonance Imaging, El-Sayed H. Ibrahim and Nael F. Osman

29 Positron Emission Tomography, Robert Splinter

30 In Vivo Fluorescence Imaging and Spectroscopy, Gregory M. Palmer and Karthik Vishwanath

31 Optical Coherence Tomography, Kevin A Croussore and Robert Splinter

32 Ultrasonic Imaging, Robert Splinter

33 Near-Field Imaging, Kert Edward

34 Atomic Force Microscopy, Christian Parigger

35 Scanning Ion Conductance Microscopy, Shelley J Wilkins and Martin F Finlan

36 Quantitative Thermographic Imaging, John Pearce

37 Intracoronary Thermography, Frank Gijsen

38 Schlieren Imaging: Optical Techniques to Visualize Thermal Interactions with Biological Tissues, Rudolf Verdaasdonk

39 Helium Ion Microscopy, John A. Notte

40 Electron Microscopy: SEM/TEM, Fernando Nieto, Juan Jimenez Millan, Gleydes Gambogi Parreira, H. Chiarini-Garcia, and R.C.N. Melo


41 Lab-on-a-Chip, Shalini Prasad, Yamini Yadav, Vindhya Kunduru, Manish Bothara, and Sriram Muthukumar

42 The Biophysics of DNA Microarrays, Cynthia Gibas

43 Nuclear Medicine, Robert Splinter


44 Biophysics of Regenerative Medicine, Amanda W. Lund, George E. Plopper, and David T. Corr

About the Editor

Dr. Robert Splinter is the Senior Scientist of Technology Development at the Spectranetics Corporation. He is also an Adjunct Assistant Professor in the Department of Physics and Optical Science at the University of North Carolina at Charlotte.

Subject Categories

BISAC Subject Codes/Headings:
SCIENCE / Physics