Handbook of Pre-Clinical Continuous Intravenous Infusion: 1st Edition (Hardback) book cover

Handbook of Pre-Clinical Continuous Intravenous Infusion

1st Edition

Edited by Guy Healing, David Smith

CRC Press

344 pages

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Hardback: 9780748408672
pub: 2000-08-31
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Description

Any scientist or technician involved in pre-clinical drug studies knows that infusing animal models with test substances is no simple matter, especially if one wants to do it humanely as well as guarantee results that are not compromised by the procedure. The challenge becomes compounded if one is employing a variety of species. What works for a rat or mouse does not necessarily work for a rabbit or primate.

The Handbook of Pre-clinical Continuous Intravenous Infusion answers the needs of researchers and technicians by providing complete instructions for a wide range of infusion techniques delivered to several species. With sections devoted to rats, mice, rabbits, dogs, mini-pigs, and nonhuman primates (both large and small), this thorough text gives step-by-step instructions for the use of a variety of techniques, and equipment. It includes procedures for multidose infusion toxicity and reproductive toxicology studies, and provides guidance on the use of a variety of equipment, including tail cuffs, harnesses, and implanted buttons. It also offers detailed information on surgical preparation for primates and mini-pigs, along with advice about the use of preoperative anesthesia, post surgical analgesics, and antibiotic administration, as well as valuable input on surgical suite design.

"… I was amazed and gratified about the level of detail and the practical emphasis on technical expertise and animal well-being. This book is unique in having that as an overt aim."

From the Foreword, David B. Morton, University of Birmingham, UK

The text concludes with a chapter on general non-species-specific information that discusses common pathological findings in continuous infusion studies, the use of mini-osmatic pumps, and controllable variables such as vehicles, rates of administration and volumes. With contributions from several established experts in the handling of pre-clinical animal models, this authoritative volume removes the need for any guesswork, allowing technicians and researchers to proceed with confidence in undertaking critical studies.

Reviews

"…an excellent buy for anyone involved in drug development, risk assessment or within drug licensing agencies and in academic research. …This book represents a benchmark achievement for this technique …it will become the standard for many years to come"

British Toxicology Society Newsletter

Table of Contents

Introduction; D. Smith and G. Healing

CONTINUOUS INTRAVENOUS INFUSION IN THE RAT

Femoral Cannulation Using the Jacket/Harness Model in the Rat; O. Green and D. Patten

Femoral Cannulation Using the Tail Cuff Exteriorisation Method in the Rat; A. McCarthy

Tethering and the Implanted Button Model in the Rat; E. Miedel

Multidose Infusion Toxicity Studies in the Rat G. Healing

Reproductive Toxicology Studies by Infusion Studies in the Rat P. Barrow

CONTINUOUS INTRAVENOUS INFUSION IN THE MOUSE

Femoral Cannulation Using the Tail Cuff Model in the Mouse H. Van Wijk and D. Robb

Multidose Infusion Toxicity Studies in the Mouse H. Van Wijk and D. Robb

Jugular Cannulation and Efficacy Studies in the Mouse I. Horii

CONTINUOUS INTRAVENOUS INFUSION IN THE RABBIT

Femoral Cannulation of the Rabbit for Reproductive Toxicity Studies C. Copeman and K. Robinson

Jugular Cannulation of the Rabbit for Reproductive Toxicity Studies E. Gordon and S. Lynch

CONTINUOUS INTRAVENOUS INFUSION IN THE DOG

Jugular Cannulation of the Dog N. Pickersgill

The Non-Ambulatory Model in Dog Multidose Infusion Toxicity Studies N. Pickersgill

The Ambulatory Model in Dog Multidose Infusion Toxicity Studies T.R. Gleason and C. Chengelis

CONTINUOUS INTRAVENOUS INFUSION IN THE PRIMATE

Surgical Preparation of the Large Primate V. Mendenhall, S. Cornell and M. Scalaro

Multidose Infusion Toxicity Studies in the Large Primate M. Walker

Surgical Preparation and Multidose Infusion Toxicity Studies in the Marmoset C. Schnell

CONTINUOUS INTRAVENOUS INFUSION IN THE MINI-PIG

Surgical Preparation of the Mini-Pig P. Brinck

Multidose Infusion Toxicity Studies in the Mini-Pig P. Brinck

Reproductive Toxicity Studies in the Mini-Pig P. McAnulty

CONTINUOUS INTRAVENOUS INFUSION - GENERAL

Common Pathological Findings in Continuous Infusion Studies J. Evans and P. Kerry

The Use of Mini-Osmotic Pumps in Continuous Infusion Studies L. Perkins, C. Peer and P. Murphy-Hackley

The Contribution of Vehicles, Rates of Administration and Volumes to Infusion Studies K. Hickling and D. Smith

Equipment for Continuous Intravenous Infusion A. Jacobson

Subject Categories

BISAC Subject Codes/Headings:
MED106000
MEDICAL / Research
SCI086000
SCIENCE / Life Sciences / General