Handbook of Proteases in Cancer Cellular and Molecular Aspects

I.  General Aspects  

 1.1. Calpain as a therapeutic target in B-cell lymphoma and other malignant diseases

 Azizul Haque^1,2,3* Naren L. Banik^1,2,3

. 1.2  Proteases in cancer: Theoretical insights on the proteases’ evolutionary pathway

Salvatore Chirumbolo^1,2*, Geir Bjorklund, Luigi Valdenassi, Sergio Pandolfi², Umberto Tirelli⁴, Antonio Vella

. 1. 3  Role of extracellular proteases in Glioblastoma

Ira Sharma, Febe Ferro, Lynden Guy Nicely, Sourav Banerjee

. 1. 4 Metalloprotease in colon cancer proliferation and metastasis

Mubarak Labaran Liman¹, Paul T. Olonishuwa², Uju Dorathy Iliemene

. 1.5 Role of proteolytic enzymes in colon cancer

Keerthi ^#, Ameena Farhana^1#,  Diptimayee Das¹, Antara Banerjee¹, Surajit Pathak

1.6.  Tumor associated fibroblast and ADAMS orchestrate tumor microenvironment in hepatocellular carcinoma

Shivani Sethuraman, Mohanprasanth Aruchamy, Sudhandiran Ganapasam

1.7 Unmasking the Protease Paradigm: Exploring the Molecular 

Complexity of Proteases in Breast Cancer

Mohd Mustafa¹, Kashif Abbas², Mudassir Alam², Sidra Islam³, Irfan Qadir Tantry⁴, Neda Tufail¹, Rizwan Ahmad¹, Bazigha Hamim¹, Waleem Ahmad⁵, Hamda Khan¹, Moinuddin¹, Imtaiyaz Hassan⁶, Nazura Usmani², Safia Habib

1. 8  Roles of MM7 in cancer

Angshuman Bagchi

1.9. The Role of Matrix Metalloproteinases MMP2 and MMP9 in Ovarian Cancer Progression

Shreya Bandopadhyay, Udit Dey, Subhadip Kundu, Debabrata Laik , Parna Chakraborty, Pallabi Debnath, Sib Sankar Roy

II. Signal Transduction Mechanisms

2.1. Role of calpains in cancer: an overview

Sajal Chakraborti*, Mahasweta Ghosh, Kausik Mondal, Priyanka Ghosh, Tapati Chakraborti

2.2. Dual role of the ADAMTS family in breast cancer

Álvaro J Obaya , Tania Fontanil

2.3. PKC isoforms and autophagy in cancer

 Alakananda Basu*, Hope K. Fiadjoe

2.4. Mechanistic insights into the ferroptotic regulation of ubiquitin specific proteases in gastrointestinal tumors

Showket Yahya, Rabitha Ravichandiran, Sudhandiran Ganapasam

2.5. Serine proteases as critical modulators of the tumor microenvironment

Dipita Bhakta-Guha*, Gunjan Guha

2.6. Protease paradigm in cancer progression: Roles of Caspase-8 and matrix metalloproteinase family in cancer with special reference to head and neck squamous cell carcinoma

Shouvik Chakravarty¹,², Arnab Ghosh¹,², Pratyusha Chikkala¹,², Nidhan K Biswas

2.7. ENTPDs in the tumor microenvironment: A promising context for cancer diagnosis

 Soni Shaikh

2.8 Matrix Metalloproteases in Breast Cancer

Dimple Patel, Sanu Thankachan¹, KP Kavitha, Saraswathy Sreeram, Shama Prasada Kabbekodu⁴, Padmanaban S Suresh

2.9. Targeting EGFR-driven signaling of MMP-2 secretion for the management of metastatic cancers

.: Loganayaki Periyasamy¹, Abhaya Krishnan², Sneha Krishnamoorthy¹, Vishwanathan M³, Sridhar Muthusami^1,4*

2.10 Protease in Signal Transduction Mechanism in Cancer: Unraveling the Role of Proteolytic Enzymes in Tumor Progression

Anjali Kumaria, Rajakishore Mishra

2.11. Sirtuin inhibition modifies matrix metalloproteinases in cancer

S.Sundaresan, S.K.Lavanya

2.12. Breast cancer metastasis– insight into Nexin-1 mediated signaling mechanism

Basavaraj Gorjanal, Monika B M, Monisha K M¹, Gobianand Kuppannan², Kanthesh M Basalingappa

2.13 The role of matrix metalloproteinase in molecular and   cellular aspects of oral squamous cell carcinoma

Iyshwarya B K¹, Ramakrishnan Veerabathiran¹*, Ganesan Sivamani², M.Nithyakalyani

2.14 The dichotomous role of CHIP in cancer

Mrinal K Ghosh¹, Sunny Kumar¹, Sayani Ghosh¹, Malini Basu

III. Gene expression, apoptosis and necrosis

3.1 Mechanisms of apoptotic/necrotic cell death-related proteases: Cysteine and serine proteases

.: Eray Metin Guler^1,2* and Beyza Nur Ozkan¹

3.2. Apoptotic and non-apoptotic roles of caspases

Bharat Bhushan^1*, Satish Kumar², Ajay Pal³, Ajay Kumar⁴, Dharam Paul Choudhary¹

3.3. Role of cysteine proteases and matrix metalloproteases in apoptosis and necrosis in cancer

Manal N. Abdel Azeem, Nour Y. S. Yassin, Noha A. Ahmed, Osama M. Ahmed

3.4. Role of SIRT1 in the regulation of gene expressions in breast cancer

  Bidyadhar Das, Kitboklang Khongsti, Superior Syngkli and Riva Mary Rani

3.5. Future Vision of Protease Inhibitors in Context of Cocktail and Singular Therapy

 Arunima Maiti¹, Arunima Sinha², Supratik Chatterjee², Danial Kordbacheh³, Riddhi Goswami², Sourav Banerjee⁴, Nilabja Sikdar²*

3.6. Regulation of cell death by cysteine proteases in breast cancer

Priyanka Saha, Anurima Samanta, Sukanya Ghosh, Rupa Chaudhuri, Dona Sinha

3.7. Ubiquitin Specific Protease 7 (USP7) – Role in human pathologies and potential targeting opportunities in cancer

.: Mrinal K Ghosh^{1, # ,*}, Srija Roy^{1, #}, Mouli Chatterjee¹, Sabana Begam¹                        and Malini Basu

Biography

Dr. Sajal Chakraborti is a Professor at the Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India. He did postdoctoral research at the Johns Hopkins Medical Institution, New York Medical College, the University of Utah, and the University of Florida. He has over 35 years of teaching and independent research experience in Biochemistry and Cell Biology. He has published over 110 original research papers, 15 review articles, and 12 books.