Handbook of Radiotherapy Physics : Theory and Practice, Second Edition, Two Volume Set book cover
2nd Edition

Handbook of Radiotherapy Physics
Theory and Practice, Second Edition, Two Volume Set

ISBN 9780367192075
Published December 31, 2021 by CRC Press
1460 Pages 757 B/W Illustrations

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Book Description

From the essential background physics and radiobiology to the latest imaging and treatment modalities, the updated second edition of Handbook of Radiotherapy Physics: Theory & Practice covers all aspects of the subject.

In Volume 1, Part A includes the Interaction of Radiation with Matter (charged particles and photons) and the Fundamentals of Dosimetry with an extensive section on small-field physics. Part B covers Radiobiology with increased emphasis on hypofractionation. Part C describes Equipment for Imaging and Therapy including MR-guided linear accelerators. Part D on Dose Measurement includes chapters on ionisation chambers, solid-state detectors, film and gels, as well as a detailed description and explanation of Codes of Practice for Reference Dose Determination including detector correction factors in small fields. Part E describes the properties of Clinical (external) Beams. The various methods (or ‘algorithms’) for Computing Doses in Patients irradiated by photon, electron and proton beams are described in Part F with increased emphasis on Monte-Carlo-based and grid-based deterministic algorithms.

In Volume 2, Part G covers all aspects of Treatment Planning including CT-, MR- and Radionuclide-based patient imaging, Intensity-Modulated Photon Beams, Electron and Proton Beams, Stereotactic and Total Body Irradiation and the use of the dosimetric and radiobiological metrics TCP and NTCP for plan evaluation and optimisation. Quality Assurance fundamentals with application to equipment and processes are covered in Part H. Radionuclides, equipment and methods for Brachytherapy and Targeted Molecular Therapy are covered in Parts I and J, respectively. Finally, Part K is devoted to Radiation Protection of the public, staff and patients. Extensive tables of Physical Constants, Photon, Electron and Proton Interaction data, and typical Photon Beam and Radionuclide data are given in Part L.

Edited by recognised authorities in the field, with individual chapters written by renowned specialists, this second edition of Handbook of Radiotherapy Physics provides the essential up-to-date theoretical and practical knowledge to deliver safe and effective radiotherapy. It will be of interest to clinical and research medical physicists, radiation oncologists, radiation technologists, PhD and Master’s students.

Table of Contents

Part A Fundamentals

Chapter 1 Structure of Matter

Jean Chavaudra

Chapter 2 Radioactivity

Jean Chavaudra

Chapter 3 Interactions of Charged Particles with Matter

Alan Nahum

Chapter 4 Interactions of Uncharged Particles with Matter

David R. Dance, Jean-Claude Rosenwald, and Gudrun Alm Carlsson

Chapter 5 Principles and Basic Concepts in Radiation Dosimetry

Alan Nahum


Part B Radiobiology

Chapter 6 Radiobiology of Tumours

Gordon Steel, Catharine West, and Alan Nahum

Chapter 7 Radiobiology of Normal Tissues

Gordon Steel and Catharine West

Chapter 8 Dose Fractionation in Radiotherapy

Gordon Steel, Catharine West, and Alan Nahum


Part C Equipment

Chapter 9 Equipment for Patient Data Acquisition

Jean-Claude Rosenwald

Chapter 10 Kilovoltage X-Ray Units

Tony Greener and David Eaton

Chapter 11 Traditional Linear Accelerators

Hamish Porter

Chapter 12 Machines with Radionuclide Sources

John Saunders, Lee Walton, and Katharine Hunt

Chapter 13 In-Room Imaging Devices Used for Treatment

Cephas Mubata

Chapter 14 CyberKnife, TomoTherapy and MR-Guided Linear Accelerators

Thomas Lacornerie, Albert Lisbona, and Andrew W. Beavis

Chapter 15 Accelerators for Protons and Other Heavy Charged Particles

Alejandro Mazal and Annalisa Patriarca


Part D Dose Measurement

Chapter 16 Ionisation Chambers

Bryan Muir and Alan Nahum

Chapter 17 Solid-State Dose Measuring Devices

Ginette Marinello

Chapter 18 Two-dimensional and Three-dimensional Dosimetry

Mark Oldham, Devon Godfrey, Titania Juang, and Andrew Thomas

Chapter 19 Reference Dose Determination under Reference Conditions

Alan Nahum and Bryan Muir

Chapter 20 Relative Dose Measurements

Ivan Rosenberg


Part E Clinical Beams

Chapter 21 The Framework Relating Measurements to Calculation of Delivered Dose

Philip Mayles

Chapter 22 Kilovoltage X-Ray Beams

Philip Mayles

Chapter 23 High-Energy Photon Beams

Philip Mayles

Chapter 24 Electron Beams

David Thwaites and Alan McKenzie

Chapter 25 Proton and Other Heavy Charged-Particle Beams

Alejandro Mazal and Ludovic de Marzi


Part F Patient Dose Calculation Methods

Chapter 26 Parameters and Methodology for Point Dose Calculation in Photon Beams

Ivan Rosenberg and Jean-Claude Rosenwald

Chapter 27 Framework for Computation of Patient Dose Distribution

Jean-Claude Rosenwald

Chapter 28 Photon Beams: Broad-Beam and Superposition Methods

Jean-Claude Rosenwald, Ivan Rosenberg, and Glyn Shentall

Chapter 29 Charged-Particle Beams: The Pencil-Beam Approach

Alan Nahum

Chapter 30 Monte-Carlo and Grid-Based-Deterministic Models for Patient Dose Computation

Alan Nahum and Jean-Claude Rosenwald




Preface to the Second Edition

The Editors

List of Contributors to the Second Edition

Part G Treatment Planning

Chapter 31 Target and Organ at Risk Definition – Dose Prescription and Reporting

Anthony Neal and Jean-Claude Rosenwald

Chapter 32 Computed Tomography Imaging in Radiotherapy

Nathalie Fournier-Bidoz

Chapter 33 Magnetic Resonance Imaging in Treatment Planning

Vincent S. Khoo

Chapter 34 Radionuclide Imaging in Treatment Planning

Yolande Petegnief

Chapter 35 Image Registration, Segmentation and Virtual Simulation

Vibeke Nordmark Hansen and Jean-Claude Rosenwald

Chapter 36 Photon-Beam Forward Planning Techniques

Peter Childs and Christine Lord

Chapter 37 Intensity-Modulated Radiation Therapy and Inverse Planning

Helen Mayles, John Fenwick, and Steve Webb

Chapter 38 Electron-Beam Treatment Planning Techniques

Alan McKenzie and David Thwaites (Updated by Philip Mayles)

Chapter 39 Proton-Beam Treatment Planning Techniques

Francesca Albertini, Alessandra Bolsi, and Juliane Daartz

Chapter 40 Intracranial and Body Stereotactic Radiotherapy

Jim Warrington and Vivian Cosgrove

Chapter 41 Total Body Irradiation

Philip Mayles

Chapter 42 Total Skin Electron Irradiation

David Thwaites and Alan McKenzie (Updated by Philip Mayles)

Chapter 43 Dose Evaluation of Treatment Plans

Margaret Bidmead and Jean-Claude Rosenwald

Chapter 44 Radiobiological Evaluation and Optimisation of Treatment Plans

Alan Nahum and Eva Onjukka


Part H Quality Assurance

Chapter 45 Quality and Safety Management

Philip Mayles, David Thwaites, and Jean-Claude Rosenwald

Chapter 46 Quality Control of High-Energy External Beams

Edwin Aird, Philip Mayles, and Cephas Mubata

Chapter 47 Quality Assurance of the Treatment Planning Process

Jean-Claude Rosenwald

Chapter 48 Quality Assurance of Treatment Delivery

Margaret Bidmead, Nathalie Fournier-Bidoz, Ginette Marinello, Jean-Claude Rosenwald, Helen Mayles

Chapter 49 Data Communication with DICOM

John Sage, John N.H. Brunt and Philip Mayles


Part I Brachytherapy

Chapter 50 Brachytherapy Clinical Introduction

Peter Hoskin

Chapter 51 Calibration and Quality Assurance of Sources

Colin H. Jones and Chris D. Lee

Chapter 52 Afterloading Equipment for Brachytherapy

Margaret Bidmead

Chapter 53 Dose Calculation for Brachytherapy Sources

Philip Mayles

Chapter 54 Brachytherapy Treatment Planning

Margaret Bidmead, Dorothy Ingham, Peter Bownes and Chris D. Lee

Chapter 55 Radiobiology of Brachytherapy

Roger Dale


Part J Therapy with Unsealed Sources

Chapter 56 Radionuclide Selection for Targeted Molecular Radiotherapy

Caroline Stokke

Chapter 57 Targeted Molecular Radiotherapy – Clinical Considerations and Dosimetry

Glenn Flux and Alan Nahum


Part K Radiation Protection in Radiotherapy

Chapter 58 Theoretical Background to Radiation Protection

Mike Rosenbloom and Philip Mayles

Chapter 59 Radiation Protection Regulation

Mike Rosenbloom and Philip Mayles

Chapter 60 Radiation Protection of Staff and the Public

Mike Rosenbloom and Philip Mayles

Chapter 61 Radiation Protection of the Patient

Philip Mayles and Uwe Schneider

Appendix K1: A Regulatory Framework (UK example

Philip Mayles

Appendix K2: Example Wall Thickness Calculations

Philip Mayles

Appendix K3: Example Local Rules for Handling Radioactive Sources

Mike Rosenbloom and Philip Mayles


Part L Data Tables

Tables L1 Physical Constants and Useful Data

Tables L2 Charged Particle Stopping Power and Range

Tables L3 Photon Interaction Coefficients

Tables L4 Typical Megavoltage Photon Beam Data.

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Philip Mayles, formerly of the Clatterbridge Centre for Oncology, UK.

Alan Nahum, formerly of the Clatterbridge Centre for Oncology, UK.

Jean Claude Rosenwald, formerly at Institute Curie, Paris, France.


Praise for the first edition:

"… Due to the broad range of topics covered and the clear, concise explanations, this text would be ideal for anyone wishing to study or refresh their knowledge of any central area of radiotherapy physics. IPEM Part 1 trainees in the UK (and any other trainee following a similar training programme elsewhere) in particular should take note … . Part 2 trainees will also benefit, especially in exploring the excellent source of referenced material. In comparison to other reference texts, the Handbook of Radiotherapy Physics is clear and also filled with many knowledgeable and useful observations and notes. … It is an excellent reference text and sits nicely on the shelf alongside your old copy of Williams and Thwaites."
SCOPE, December 2009

"… comprehensive reference … With contributions from renowned specialists, this book provides essential theoretical and practical knowledge to deliver safe and effective radiotherapy."
Anticancer Research, 2009, Vol. 29

"The editors have managed with great success to assemble the information submitted by the contributing authors and put it in a format that is concise, easy to read, and rich in content … it can serve as an excellent reference manual and resource."
Niko Papanikolaou, University of Texas Health Sciences Center, Medical Physics, September 2008, Vol. 35, No. 9

Praise for the second edition:

"This is the 2nd edition of the Handbook of Radiotherapy published in 2007. The book is organized into 11 parts, each dealing with a self-contained subject area including but not limited to Fundamentals, Radiobiology, Equipment, Dose Measurement, Treatment Planning, Quality Assurance, Therapy with Unsealed Sources, and Radiation Protection. An additional part has been included at the end of Vol.2, which provides tables of physical constants and radiation interaction data. This textbook is meant to be a comprehensive handbook practical radiotherapy knowledge for both medical that covers theoretical and physics trainees and practicing medical physicists. It provides a good overview of theoretical knowledge along with a practical description of concepts. In keeping with the original intent of the first edition, this book is intended primarily as course book for physicists in training but could also act as a reference book for practicing radiation physicists. It is a useful supplement to classic radiotherapy textbooks; concepts are introduced very well and extensive references are provided if the readers require a more in-depth review. The editors and authors have wide ranging medical physics experience across the UK, Europe, and U.S.

The text is very comprehensive, with sections covering classic topics in the field along with modern topics such as knowledge-based planning, artificial intelligence, and MR-guided linear accelerators. I especially appreciated the quality assurance (QA) part, which included chapters ranging from QA of treatment planning and treatment delivery to data communication with DICOM. Overall, this is a well-written handbook. Due to the extensive changes in the field of medical physics since 2007, this is a necessary and thoughtful update. The editors did a great job of assembling a huge amount of information. Given the breadth and scope of this text, along with the extensive bibliography, this handbook would be a great resource, especially for trainees and early career physicists."
—Katelyn Hasse (University of California, San Francisco), in Medical Physics, The International Journal of Medical Physics Research and Practice (July 2022)