2nd Edition

Handbook of Radiotherapy Physics
Theory and Practice, Second Edition, Two Volume Set

  • Available for pre-order. Item will ship after December 31, 2021
ISBN 9780367192075
December 31, 2021 Forthcoming by CRC Press
1460 Pages 757 B/W Illustrations

USD $450.00

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Book Description

From the essential background physics and radiobiology to the latest imaging and treatment modalities, the updated second edition of Handbook of Radiotherapy Physics: Theory & Practice covers all aspects of the subject.

In Volume 1, Part A includes the Interaction of Radiation with Matter (charged particles and photons) and the Fundamentals of Dosimetry with an extensive section on small-field physics. Part B covers Radiobiology with increased emphasis on hypofractionation. Part C describes Equipment for Imaging and Therapy including MR-guided linear accelerators. Part D on Dose Measurement includes chapters on ionisation chambers, solid-state detectors, film and gels, as well as a detailed description and explanation of Codes of Practice for Reference Dose Determination including detector correction factors in small fields. Part E describes the properties of Clinical (external) Beams. The various methods (or ‘algorithms’) for Computing Doses in Patients irradiated by photon, electron and proton beams are described in Part F with increased emphasis on Monte-Carlo-based and grid-based deterministic algorithms.

In Volume 2, Part G covers all aspects of Treatment Planning including CT-, MR- and Radionuclide-based patient imaging, Intensity-Modulated Photon Beams, Electron and Proton Beams, Stereotactic and Total Body Irradiation and the use of the dosimetric and radiobiological metrics TCP and NTCP for plan evaluation and optimisation. Quality Assurance fundamentals with application to equipment and processes are covered in Part H. Radionuclides, equipment and methods for Brachytherapy and Targeted Molecular Therapy are covered in Parts I and J, respectively. Finally, Part K is devoted to Radiation Protection of the public, staff and patients. Extensive tables of Physical Constants, Photon, Electron and Proton Interaction data, and typical Photon Beam and Radionuclide data are given in Part L.

Edited by recognised authorities in the field, with individual chapters written by renowned specialists, this second edition of Handbook of Radiotherapy Physics provides the essential up-to-date theoretical and practical knowledge to deliver safe and effective radiotherapy. It will be of interest to clinical and research medical physicists, radiation oncologists, radiation technologists, PhD and Master’s students.

Table of Contents

Interaction of Charged Particles with Matter
Interactions of Photons with Matter
The Monte Carlo Simulation of Radiation Transport
Principles and Basic Concepts in Radiation Dosimetry

Radiobiology of Tumors
Radiobiology of Normal Tissues
Dose Fractionation in Radiotherapy

Kilovoltage X-Ray Units
Linear Accelerators
Cobalt Machines
Portal Imaging Devices

Ionisation Chambers
Radiothermoluminescent Dosimeters and Diodes
Radiation Sensitive Films and Gels
Absolute Dose Determination under Reference Conditions
Relative Dose Measurements and Commissioning

From Measurements to Calculations
Kilovoltage X-Rays
Megavoltage Photon Beams
Manual Dose Calculations in Photon Beams
Electron Beams

Principles of Patient Dose Computation
Patient Dose Computation for Photon Beams
Patient Dose Computation for Electron Beams
Monte-Carlo Based Patient Dose Computation

Target Definition
Patient Data Acquisition
Magnetic Resonance (MR) Imaging in Treatment Planning
Beam Definition - Virtual Simulation
Photon-Beam Treatment Planning Techniques
Electron-Beam Treatment Planning Techniques
Dose Evaluation of Treatment Plans
Biological Evaluation of Treatment Plans

Rationale and Management of the Quality System
Quality Control of Megavoltage Equipment
Quality Assurance of the Treatment Planning Process
Quality Control of Treatment Delivery
Recording and Verification - Networking
Data Communication with DICOM

Conformal and Intensity-Modulated Radiation Therapy
Intensity-Modulation Therapy: Practical Aspects
Stereotactic Techniques
Proton Beams in Radiotherapy
Total Body Irradiation (TBI)
Total Skin Electron Irradiation
High LET Modalities

Clinical Introduction to Brachytherapy
Calibration and Quality Assurance of Brachytherapy Sources
Afterloading Equipment for Brachytherapy
Dose Calculation for Brachytherapy Sources
Brachytherapy Treatment Planning
Radiobiology of Brachytherapy

Dosimetry of Unsealed Sources
Radionuclide Selection for Unsealed Source Therapy
Radiopharmaceutical Targeting for Unsealed Source Therapy

Theoretical Background to Radiation Protection
Radiation Protection Regulation
Practical Radiation Protection in Radiotherapy
Radiation Protection Regulation in the United Kingdom


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Philip Mayles, Clatterbridge Centre for Oncology, UK.

Alan Nahum, formerly of the Clatterbridge Centre for Oncology, UK.

Jean Claude Rosenwald, Institute Curie, Paris, France.


Praise for the first edition:

"… Due to the broad range of topics covered and the clear, concise explanations, this text would be ideal for anyone wishing to study or refresh their knowledge of any central area of radiotherapy physics. IPEM Part 1 trainees in the UK (and any other trainee following a similar training programme elsewhere) in particular should take note … . Part 2 trainees will also benefit, especially in exploring the excellent source of referenced material. In comparison to other reference texts, the Handbook of Radiotherapy Physics is clear and also filled with many knowledgeable and useful observations and notes. … It is an excellent reference text and sits nicely on the shelf alongside your old copy of Williams and Thwaites."
SCOPE, December 2009

"… comprehensive reference … With contributions from renowned specialists, this book provides essential theoretical and practical knowledge to deliver safe and effective radiotherapy."
Anticancer Research, 2009, Vol. 29

"The editors have managed with great success to assemble the information submitted by the contributing authors and put it in a format that is concise, easy to read, and rich in content … it can serve as an excellent reference manual and resource."
Niko Papanikolaou, University of Texas Health Sciences Center, Medical Physics, September 2008, Vol. 35, No. 9