1st Edition
Handbook of Regenerative Medicine Cell-Free Therapy Approach
About the Editor
List of Contributors
Chapter 1 Extracellular Vesicles as in Dentistry from Laboratory to Clinic
S.-L. Ng, J.-X. Law, and F. Yazid
Chapter 2 Extracellular Vesicles–Based Cell-Free Therapies in Cardiovascular Diseases
Hongyun Wang, Xuan Ye, Yiqing Chen, Marta Garcia-Contreras, Zilin Guo, Juan Gao, Guoping Li, and Junjie Xiao
Chapter 3 Regenerative Therapy with Extracellular Vesicles in Acute and Chronic Kidney Injury
Alexander E. Berezin and Tetiana A. Berezina
Chapter 4 Isolation and Characterization of IPSC EVs Preconditioned with Severe Critically Ill COVID-19 Patient’s Serum
Radiana Dhewayani Antarianto, Suratno Lulut Ratnoglik, Meutia Admiralda Andini, Nurhamitha Humairoh, Adrian Pragiwaksana, Dita Aditianingsih, Ismail Hadisoebroto Dilogo, and Jeanne Adiwinata Pawitan
Chapter 5 Therapeutic Efficacy of Mesenchymal Stem Cells and Their Derived Exosomes in Different Neurodegenerative Disorders: Current Status and Future Perspectives
Lamiaa A. Ahmed, Khaled F. Al-Massri, and Khawaja Husnain Haider
Chapter 6 Applications and Implications of Mesenchymal Stem Cell-Derived Exosomes in Ophthalmology
K.Y. Wu, G. Lin, M.C. Louismé, Marjorie Carbonneau, and S.D. Tran
Chapter 7 Future Management of Type 2 Diabetes and Its Complications by Mesenchymal Stem Cell−Derived Exosomes (MSC-Exos)
Avinash Sanap, Avinash Kharat, and Ramesh Bhonde
Chapter 8 Liquid Biopsy Biomarkers for Personalized Management in Heart Failure
Alexander E. Berezin and Oleksandr O. Berezin
Chapter 9 Prospective Implications of Autologous Platelet-Rich Plasma in Tissue Engineering and Organ Rejuvenation
Saravanan Ramesh, Victor Samuel, Karthikeyan Meenakshisundaram, Durga Kathirvelu, Arthi Sunil Richard, Khawaja Husnain Haider, and Kavitha Govarthanan
Chapter 10 Cell-Free and Cell-Based Therapy in Regenerative Medicine
Yujie Liang, Jiang Xia, Limei Xu, Yuanming Zhang, Xiao Xu, and Khawaja Husnain Haider
Chapter 11 Mesenchymal Cell-Free and Cell-Based Therapy in Regenerative Medicine: A Crucial Exploration of Formulation, GMP Production, Regulatory Approval, and Market Access
E. Bari, M.L. Torre, and C. Jommi
Chapter 12 Unveiling Mesenchymal Stem Cells Secretome Potentials in Regenerative Medicine and Disease Therapeutics
Ranjeet Singh Mahla
Chapter 13 Engineering Therapeutic Mesenchymal Stem Cells Secretome for Bone Regeneration
Alberto González-González, Itziar Álvarez-Iglesias, Flor M. Pérez-Campo, Luis Antonio Diaz-Gomez, and Patricia Díaz-Rodríguez
Chapter 14 Cell-Free Scaffolding: A Tissue-Engineering Approach with the Potential to Revolutionize the Regeneration of Chondral Tissue
Mario A. Simental-Mendia, Elsa N. Garza-Treviño, Juan Antonio Rojas Murillo, Jorge A. Roacho-Perez, Gerardo R. Padilla-Rivas, and Jose Francisco Islas
Chapter 15 The Secretome of Mesenchymal Stromal Cells in Treating Intracerebral Hemorrhage: Our Experience
Stalik Dzhauari, Nataliya Basalova, Alexandra Primak, Anastasia Efimenko, Vadim Balabanyan, Kirill Bozov, Zhanna Akopyan, Vsevolod Tkachuk, and Maxim Karagyau
Chapter 16 Stem Cell Secretome as Theranostics for Traumatic Brain Injury
Suleiman Alhaji Muhammad, Abdulwasiu Ibrahim, Amina Jiyah, Abdullahi Yahya Abbas, Yusuf Saidu, Lawal Suleiman Bilbis, and Sharida Fakurazi
Chapter 17 Cell-Free and Cell-Based Therapies in Regenerative Medicine
Sarah Miremadi, Alireza Rajabzadeh, Ali Dehghani Firouzabadi, Elahe Esmaeili, Amin Ebrahimi Sadrabadi, Maryam Hasani, Moustapha Hassan, and Massoud Vosough
Chapter 18 Mesenchymal Stem Cell Secretomes for Cell-Free Therapy of the Broken Heart
Syed Mohammad Habib, Mohammad Fateh Martini, Omran Al Ahmed, Abdullah Radwan Qassab, and Khawaja Husnain Haider
Chapter 19 From 2D to 3D and Cellular to Cell-Free: Evolutions in Strategies for Regenerative Medicine
Shalini Raik and Shalmoli Bhattacharyya
Chapter 20 Cell-Free and Cell-Based Approaches in Neurological Surgery
Sara Mohammadi, Abdol-Mohammad Kajbafzadeh, Alireza Soltani Khaboushan, and Afarin Neishabouri
Chapter 21 A Clinical Overview of Cell-Free and Cell-Based Therapies in Regenerative Medicine
Naba Farooqui and Mrudula Munagala
Chapter 22 Autologous versus Allogenic Mesenchymal Stem Cells in Heart Disease: Revisiting Preclinical and Clinical Trials
Omar T. Ahmed, Ziyad T. Ahmed, Abdulrahman W. Dairi, Rana H. Alkahlot, Ghazi I. Al Jowf, and Khawaja Husnain Haider
Chapter 23 Exosomes and Encapsulated ExomiRs in Breast Cancer: Theragnostic Applications and Clinical Implications
Muhammad Imran Sajid, Shafia Bukhari, Hamid Ilyas, Rubina Malik, Minahil Fatima, Rakesh Kumar Tiwari, Surya M. Nauli, and Khawaja Husnain Haider
Chapter 24 The Potential of Mesenchymal Stem Cell−Derived Exosomes in Cell-Free Therapy for Myocardial Repair
Syed Mohammad Habib, Khawaja Husnain Haider, and Mohammad Fateh Martini
Chapter 25 Theragnostic Applications of Exosomes in Alzheimer’s Disease
Rukh Yusuf and Khawaja Husnain Haider
Index
Biography
Dr. Khawaja Husnain Haider is a Professor of Cellular and Molecular Pharmacology (Stem Cell and Gene Therapy) and Chairman of the Basic Sciences Department (Medical Program) at Sulaiman AlRajhi University. Before his current assignment, he served in several prestigious institutions in various parts of the world. He has also served as Principal Investigator (PI) and Co-PI on multiple National Institute of Health (NIH) funded stem cell research projects. He has been on the editorial boards and invited reviewer panels for several respected international journals. His research focuses on using, either alone or in combination, DNA, miRNAs, and stem cells as “drugs,” a topic that has gained popularity in regenerative medicine. He has extensively published on cellular and sub-cellular preconditioning of stem cells and using their conditioned media for cell-free therapy. He has published nearly 350 book chapters, abstracts, and research papers in various books and leading research journals, including Circulation, Circulation Research, Cardiovascular Research, JCMM, the Journal of Biological Chemistry, Cell Cycle, Basic Research in Cardiology, and Antioxidant Redox Signaling. He has also given numerous presentations and edited ten books covering various facets of stem cells and their applications from drug to drug development.
