1st Edition

Handbook of Regenerative Medicine Stem Cell-based Approach

Edited By Khawaja Husnain Haider Copyright 2025
454 Pages 107 Color & 1 B/W Illustrations
by CRC Press

454 Pages 107 Color & 1 B/W Illustrations
by CRC Press

This handbook comprehensively explores various facets of stem cells in regenerative medicine, highlighting the interdisciplinary nature of the research. It covers the biology, characteristics, and applications of mesenchymal and non-mesenchymal stem cells in diverse medical contexts. The potential for treating radiation injuries, spinal cord injuries, diabetes, aging-related diseases,... Read more

Chapter-1

Mesenchymal Stromal Cell: Basic characteristics and Interaction with the Immune System

Charalampos Oikonomidis, Panagiotis Mallis

 

Chapter 2

Significant Progress in Stem Cell Treatment for Alzheimer’s Disease: A Critical Review

1Karina Petkova^, 1Prabriti Neupane^, 2Sarah Schmitt^, 1Nischal Neupane, 1Rajprasad Loganathan, 1Li Yao*

 

Chapter-3

Regenerative Medicine in Ophthalmology

G. Lin,  M. Kulbay, KY. Wu, SD. Tran

 

Chapter-4

Cell Therapy for Diabetes

Mikhail Konoplyannikov, Fedor Zabozlaev, Alexander Smirnov1, Peter Timashev

 

Chapter-5

Revisiting Preclinical and Clinical Trials of Mesenchymal Stem Cells in Heart Disease to Define a Dose-Response

Ziyad T. Ahmed, Maha Saad Zain Al-Abeden, Ghazi I. Al Jowf, Lars M. T. Eijssen, Mohamad Ayham Muqresh, Mohamed Ghaith Al Abdin, Khawaja Husnain Haider

 

Chapter-6

Stemming Pain Sensations with Stem Cells

Eman Ibrahim Anwar, Syeda Ayesha Fatima, Dalia Magdi Ismail, Khawaja H Haider

 

Chapter-7

Osteoarthritis treatment between bio-stimulation and cell therapy

Najib Al idrissi, Nihal Habib, Hassan Ghazal, Mohamed Merzouki, Mustapha Najimi, Anissa Regragui

 

Chapter-8

Cellular Architects of Healing: Mesenchymal Stem Cell-Based Strategies for Fibrosis

Renata Szydlak

 

Chapter-9

Stem cells and mineralized plasmatic matrix therapy in oral surgery

Anissa Regragui, Sara Ouled Saber, Hassan Ghazal, Mohamed Merzouki,

Mustapha Najimi, Najib Al idrissi

 

Chapter-10

Role of stem cell-based therapy in neurodegenerative, ocular, and cardiovascular disease

Sayan Paul, Rajesh Srinivasan, Salma Mohammed, Anandhi Kannan, Vignesh Mariappan, Öznur Özge Özcan, İbrahim Şahbaz, Vijayaraj Kumar Palanirajan, Muhsin Konuk, Tungki Pratama Umar, Drishanu Dey, Mesut Karahan, Khawaja Husnain Haider

 

Chapter-11

Stem Cells Regenerative Therapy in Cardiac Disease: Lessons from Embryonic Development, Current Evidence for Clinical Application and Potential Future Directions

Hatem Mohamed, Hamed Mahmoud Hamed El-hawal, Khaled Ismaeil, Menna-allah Elbisi, Amr Zaher

 

Chapter-12

Challenges And Opportunities in the Study of Bone Marrow-Derived Mesenchymal Stromal Cells: From Where We Stand to Where We Go

Marcia Bastos Convento, Fernanda Teixeira Borges

Chapter 13

Mesenchymal stem cell-mediated therapy in regenerative medicine

M. Mavis, H. Cagsin, N. Serakinci

 

Chapter-14

Routes of Administration of Mesenchymal Stem Cell Therapy in Cardiac Therapy

Muhammad Chandragupta Jihwaprani, Mohamed Ahmed Charbat, Idris Sula, Khawaja Husnain Haider

 

Chapter-15

Neuronal Stem Cells and Regenerative Medicine: Harnessing the Potential for Neural Repair

Ranjeet Singh Mahla

 

Chapter 16

Biomaterial Nanofiber Scaffolds for Neural Regeneration

Linh Huynh, Li Yao

 

Chapter-17

Cell-free and Cell-based Therapy in Treating Spinal Cord Injuries

 

Chapter 18

20-Year Life Prolongation Achieved through Muscle Regeneration by Implanting 50-Billion Allogeneic Myoblasts into Duchenne Muscular Dystrophy (DMD) Boys

Peter K. Law, Danlin M. Law, Ping Lu, Ming Zhang Ao, and Long Jiang Yu

 

Chapter-19

Reversing Insulin Resistance by Novel Cell-based and Cell-free Therapy Approaches with Skeletal Myoblasts

Khawaja Husnain Haider, Mateq Ali Alreshidi, Mabrouk AL-Rasheedi, Kholood S. Aldmasi

 

Chapter-20

Current progress and challenges of non-genetically modified natural killer (NK) cell-based immunotherapy.

*Law JX, Ng MH, Lokanathan Y, Chan AML, Cheah JM

 

Chapter-21

Identification of Potential Botanical Drug Leads for Stem Cell Therapy: Cues

from Sri Lankan Traditional Medicine

Preethi Udagama, Vindya Udalamaththa, and Praneeth Ratnayake

 

 

Chapter-22

Cell-based Therapy for Cancer in Regenerative Medicine

*Figen Abatay Sel, Fatma Savran Oğuz

 

Chapter-23

Lung regeneration against lung diseases: a near future reality?

Beatrice Aramini, Valentina Masciale, Federico Banchelli, Anna Valeria Samarelli, Simone De Sario, Martina Palazzi, Alessia Malagola, Elisa Targhini, Maria Cristina Poggiolini, Christian Di Carlo, Massimo Dominici, Franco Stella, Khawaja Husnain Haider

 

Chapter-24

The pivotal role of glioma stem cells in promoting glioma radio-chemoresistance, progression, and recurrence is a topic of significant interest and potential breakthroughs in neurosurgery, oncology, and molecular biology. These potential breakthroughs inspire hope for improved treatment strategies and patient outcomes.

Edoardo Agosti, Marco Zeppieri, Amanuel Giudici, Sara Antonietti, Tamara Ius, Marco Maria Fontanella, Pier Paolo Panciani

 

Chapter-25

Significance of Targeting Cancer Stem Cells in Gynaecologic Cancer

Kazunori Nagasaka

 

Chapter-26

Role of Stem Cells in diabetes, liver disease, and cancer treatment

Rajamanikkam Kamaraj, Mohammad Javad Mehran, Harshita Tiwari, Monu Kumar Shukla, Mehmet Veysi Cetiz, Zarrin Basharat, Rambod Barzigar, Sana Jalili, Petr Pávek, Ranjith Kumavath, Manash K. Paul, Khawaja Husnain Haider, Sayan Paul

 

Chapter-27

Pluripotent Stem Cells: A Hope to Move Forward for Cardiovascular Applications

Rawan Yousef N Albalawi, Zilal Alchalabi, Leen Aljajah, Shahd Almasri,

Khawaja H Haider

 

Biography

Dr. Khawaja Husnain Haider is a Professor of Cellular and Molecular Pharmacology (Stem Cell and Gene Therapy) and Chairman of the Basic Sciences Department (Medical Program) at Sulaiman AlRajhi University. Before his current assignment, he served in several prestigious institutions in various parts of the world. He has also served as Principal Investigator (PI) and Co-PI on multiple National Institute of Health (NIH) funded stem cell research projects. He has been on the editorial boards and invited reviewer panels for several respected international journals. His research focuses on using, either alone or in combination, DNA, miRNAs, and stem cells as “drugs,” a topic that has gained popularity in regenerative medicine. He has extensively published on cellular and sub-cellular preconditioning of stem cells and using their conditioned media for cell-free therapy. He has published nearly 350 book chapters, abstracts, and research papers in various books and leading research journals, including Circulation, Circulation Research, Cardiovascular Research, JCMM, the Journal of Biological Chemistry, Cell Cycle, Basic Research in Cardiology, and Antioxidant Redox Signaling. He has also given numerous presentations and edited ten books covering various facets of stem cells and their applications from drug to drug development.