3rd Edition

Handbook of Toxicology

ISBN 9781439890134
Published March 7, 2014 by CRC Press
1022 Pages 7 Color & 340 B/W Illustrations

USD $195.00

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Book Description

The Handbook of Toxicology, Third Edition provides an updated practical reference source for practicing toxicologists in the pharmaceutical and chemical industries, contract laboratories, regulatory agencies, and academia. Written by experts in their specific toxicology fields, the chapters provide both fundamental and applied information. Topics range from General Toxicology, to Genetic Toxicology, Human Clinical Toxicology, Histopathology, Clinical Pathology, Metabolism and Toxicokinetics, Risk Assessment, and more.

New to this edition:

  • Completely rewritten chapters covering immunotoxicology, endocrine toxicology, and reproductive and developmental toxicology, providing a fresh perspective on these topics
  • Addition of new chapters on Chemical Toxicology, Pharmaceutical Toxicology, Juvenile Toxicology, and Safety Pharmacology
  • Updated information dealing with Inhalation Toxicology, Neurotoxicology, and Regulatory Toxicology, which has been consolidated into single chapters for each specialty
  • A separate glossary with toxicological terms presented both alphabetically and by toxicological subspecialty

For nearly 20 years, this handbook has remained the only reference book of its kind, designed to facilitate easy access to information related to the various toxicology specialties. This updated edition of a popular reference book reflects current practices and the state of the science of toxicology.

Table of Contents

Laboratory Animal Management; Joseph C. Siglin, William H. Baker, Aaron M. Sargent, Binod Jacob, and Mark A. Morse

General Toxicology; Carol S. Auletta

Dermal Toxicology; Kimberly L. Bonnette

Ocular Toxicology; Brendan J. Dunn and Kathryn S. Monds

In Vitro
Methods for the Prediction of Ocular and Dermal Toxicity; John W. Harbell and Hans Raabe

Inhalation Toxicology; Gary M. Hoffman, Stuart Cracknell, Justine M. Damiano, Nicholas P. Macri, and Simon Moore

Neurotoxicology; Rosemary C. Mandella

Immunotoxicology; Gary R. Burleson, Florence G. Burleson, and Victor J. Johnson

Renal Toxicology; William J. Powers, Jr.

Developmental and Reproductive Toxicity; Robert M. Parker

Juvenile Toxicology; Robert M. Parker

Endocrine Toxicology; Rochelle W. Tyl

Genetic Toxicology; Marilyn J. Aardema, Valentine O. Wagner III, Jane J. Clarke, Rohan Kulkarni, Shambhu Roy, Yong Xu, Kamala Pant, Leon F. Stankowski, Jr., Tim Lawlor, and Robert R. Young

Carcinogenesis; Michael J. Derelanko

Histopathology; John C. Peckham

Clinical Pathology; Barry S Levine

Metabolism and Toxicokinetics of Xenobiotics; Mohamed B. Abou-Donia

Human Clinical Toxicology; Jill Dolgin and Michael J. Derelanko

Chemical Toxicology; Michael J. Derelanko

Pharmaceutical Toxicology; William J. Brock, and Lorrene A. Buckley

Safety Pharmacology; Theodore J. Baird, Jill A. Dalton, and David V. Gauvin

Risk Assessment; Michael J. Derelanko

Regulatory Toxicology; Carol S. Auletta

Appendix A: LD50 Values
Appendix B: Tables of Comparative Anatomical, Physiological, and Biochemical Data
Appendix C: Mathematics, Symbols, Physical Constants, Conversions, and Statistics
Appendix D: Calculations, Preparation, and Properties of Substances Used in Toxicology
Appendix E: Design and Performance of Toxicology Studies
Appendix F: Organizations and Agencies
Appendix G: Acronyms
Appendix H: Academic Programs in Toxicology
Appendix I: Physical/Chemical Information
Glossary: By Subject

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Michael J. Derelanko, PhD, DABT, FATS, has spent most of his career as a toxicologist in the pharmaceutical and chemical industries. He most recently was director of nonclinical drug safety assessment for Adolor Corporation where he contributed to the discovery and development of novel drugs for nearly ten years. Prior to that, as manager of toxicology and risk assessment for Honeywell International, he supported the company’s chemical businesses for over two decades. He currently is employed by Critical Path Services, a Knoell company, where he provides expertise in toxicology and hazard communication.

Carol S. Auletta, DABT, RAC, MBA, has worked in toxicology research for more than 30 years. She is board certified in toxicology by the American Board of Toxicology and in regulatory affairs by the Regulatory Affairs Professionals Society. Carol has spent her career in the CRO industry and currently serves as a senior director in safety assessment and the director of program management at Huntingdon Life Sciences in East Millstone, New Jersey.

Featured Author Profiles

Author - Michael J.  Derelanko

Michael J. Derelanko

, Diplomate American Board of Toxicology/Fellow Academy of Toxicological Sciences
, Pennsylvania, U.S.A.

Learn more about Michael J. Derelanko »


"In summary, an excellent book which this review confirms totally adds up to the claim that it is ‘an updated practical reference source for practicing toxicologists in the pharmaceutical and chemical industries, contract laboratories, regulatory agencies, and academia.’ If you are one of these, then buy the book!"
—Paul Baldrick, Covance Laboratories Ltd, UK in bst News

"This is an excellent consolidated reference, full of information that is useful to professional toxicologists. There are very few books that serve a similar purpose."
—Mitchell McGill, PhD, University of Kansas Medical Center in for Doody's Review Service