680 pages | 70 Color Illus. | 172 B/W Illus.
Tumors/cancers are characterized by uncontrolled growths of abnormal cells that extend beyond their usual boundaries and disrupt the normal functions of affected organs and systems. While about 85% of tumors/cancers arise sporadically without family connection, 15% appear to result from inheritance of genetic mutations, some (5-10%) of which are responsible for causing tumor syndromes (or cancer susceptibility syndromes). In comparison with sporadic tumors/cancers, those associated with tumor syndromes (>300 described so far) tend to occur at a younger age, involve multiple organs and systems, produce multiple (often in a distinct spectrum) and bilateral lesions, associate with multiple hamartomatous, benign, or precursor lesions, locate in specific site, display unique syndromic features, and affect multiple members/generations of family.
This book provides a state-of-art and authoritative coverage of nearly 100 tumor syndromes. Each chapter presents an overview of a particular tumor syndrome in relation to its biology, epidemiology, pathogenesis, clinical features, diagnosis, treatment and prognosis. With contributions from oncologists, clinicians and specialists, this book offers a useful reference for scholars and students of medicine, dentistry, pharmacology, nursing, public health and other biomedical disciplines.
J. R. McIntosh. Understanding Cancer: An Introduction to the Biology, Medicine, and Societal Implications of this Disease (ISBN 978-0-8153-4535-0)
P. S. T. Shanmugam. Understanding Cancer Therapies (ISBN 978-1-1381-9815-9)
J. M. Baehring and J. M. Piepmeier, eds. Brain Tumors: Practical Guide to Diagnosis and Treatment (ISBN 978-0-3673-9022-8)
D. Liu. Tumors and Cancers: Endocrine Glands – Blood – Marrow – Lymph (ISBN 978-1-4987-2975-8)
Dongyou Liu, Ph.D., studied veterinary science at Hunan Agricultural University, China and undertook postgraduate training at the University of Melbourne, Australia. Over the past three decades, he has worked at several research and clinical laboratories in Australia and the United States of America, with focuses on molecular characterization of microbial pathogens and detection of human genetic disorders and tumors/cancers. He is the primary author of >50 original research and review articles in various international journals, the contributor of 197 book chapters, and the editor of Molecular Detection of Human Viral Pathogens (2010), Molecular Detection of Human Bacterial Pathogens (2011), Molecular Detection of Human Fungal Pathogens (2011), Molecular Detection of Human Parasitic Pathogens (2012), Molecular Detection of Animal Viral Pathogens (2016), and Handbook of Foodborne Diseases (2018) as well as the co-editor of Molecular Medical Microbiology 2nd edition (2014). He is also the founding series editor and author of several volumes in the Pocket Guides to Biomedical Sciences book series.
Introductory remarks. Tumor Syndromes Affecting Central and Peripheral Nervous Systems. Aicardi syndrome (Klinefelter syndrome). Hereditary neuroblastoma. Neurofibromatosis types 1 and 2. Rhabdoid tumor predisposition syndrome. Tumor Syndromes Affecting Digestive System. Familial adenomatous polyposis. Familial gastrointestinal stromal tumor. Familial juvenile polyposis. Gardner syndrome (or familial colorectal polyposis). Hereditary diffuse gastric cancer (HDGC). Lynch syndrome (hereditary non polyposis colon cancer or Turcot syndrome). MUTYH associated polyposis. Peutz-Jeghers syndrome. Tumor Syndromes Affecting Urogenitory System. Birt–Hogg–Dubé Syndrome. Hereditary breast cancer and ovarian cancer syndrome (BRCA1, BRCA2). Cowden syndrome (PTEN hamartoma tumor syndrome). Hereditary leiomyomatosis and renal carcinoma (HLRCC). Hereditary papillary renal cell cancer (HPRCC). Hereditary prostate cancer. Tumor Syndromes Affecting Skin, Soft Tissue and Bone. Basal cell nevus syndrome (or Gorlin syndrome). Costello syndrome. Familial chordoma. Familial atypical multiple mole melanoma syndrome. Hereditary multiple exostoses (or hereditary multiple osteochondromas). Howel-Evans syndrome (Tylosis with esophageal cancer). Mosaic variegated aneuploidy syndrome. Rothmund-Thomspon syndrome. Xeroderma pigmentosum. Tumor Syndromes Affecting Endocrine System. Beckwith–Wiedemann syndrome. Familial hyperparathyroidism. Hereditary paraganglioma-pheochromocytoma syndrome. Mahvash disease. Multiple endocrine neoplasia types 1, 2, 4. Tumor Syndromes Affecting Hematopoietic and Lymphoreticular Systems. Ataxia-telangiectasia syndrome (or Louis–Bar syndrome). Bloom syndrome. Dyskeratosis congenita (or Zinsser-Engman-Cole syndrome). Familial acute myeloid leukemia. Familial chronic lymphocytic leukemia. Familial Hodgkin lymphoma. Familial non-Hodgkin lymphoma. Familial multiple myeloma. Fanconi anemia. Nijmegen breakage syndrome. Tumor Syndromes Affecting Multiple Organs/Systems. BAP1 hereditary cancer predisposition syndrome. Carney complex. Li-Fraumeni syndrome. McCune-Albright syndrome. Retinoblastoma. Tuberous sclerosis (TSC1 and TSC2). Von Hippel-Lindau syndrome (VHL)