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Handbook of Tumor Syndromes




ISBN 9780815393801
Published May 21, 2020 by CRC Press
846 Pages 70 Color & 172 B/W Illustrations

 
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Book Description

Tumors/cancers are characterized by uncontrolled growths of abnormal cells that extend beyond their usual boundaries and disrupt the normal functions of affected organs and systems. While about 75%–80% of tumors/cancers arise sporadically without a family connection, 20%–25% appear to be familial (including 10%–15% nonhereditary familial tumors [or familial tumors] and 5%–10% hereditary familial tumors [or hereditary tumors]). As nonhereditary and hereditary familial tumors often show both tumor-related and non-tumor-related (or syndromic) symptoms, they are referred to as tumor syndromes (or cancer susceptibility syndromes).

In comparison with sporadic tumors/cancers, tumor syndromes (>300 described so far) tend to occur at a younger age, involve multiple organs and systems, produce multiple (often in a distinct spectrum) and bilateral lesions, form multiple hamartomatous, benign, or precursor lesions; locate in specific site(s), display unique syndromic features, and affect multiple members/generations of a family.

This book provides state-of-art and authoritative coverage of nearly 100 tumor syndromes, with chapters presenting overviews of individual tumor syndromes in relation to their biology, epidemiology, pathogenesis, clinical features, diagnosis, treatment, and prognosis. Featuring contributions from oncologists, clinicians, and specialists, the book offers a reliable, comprehensive reference on tumor syndromes for scholars and students of medicine, dentistry, pharmacology, nursing, public health, and other biomedical disciplines.

Key Features

  • Reviews the biology, epidemiology, pathogenesis, and clinical features of tumor syndromes
  • Contains up-to-date information on the diagnosis and treatment of tumor syndromes
  • Includes expert coverage from leading oncologists and clinicians

Related Titles

J. R. McIntosh, Understanding Cancer: An Introduction to the Biology, Medicine, and Societal Implications of This Disease (ISBN 978-0-8153-4535-0)

P. S. T. Shanmugam, Understanding Cancer Therapies (ISBN 978-1-1381-9815-9)

J. M. Baehring and J. M. Piepmeier, eds., Brain Tumors: Practical Guide to Diagnosis and Treatment (ISBN 978-0-3673-9022-8)

D. Liu, Tumors and Cancers: Endocrine Glands – Blood – Marrow – Lymph (ISBN 978-1-4987-2975-8)

Dongyou Liu, PhD, has worked at several research and clinical laboratories in Australia and the United States for the past three decades, with a focus on molecular characterization of microbial pathogens and detection of human genetic disorders and tumors/cancers. He is the primary author of more than 50 original research and review articles in various peer-reviewed international journals, the contributor of 197 book chapters, and the editor of more than 10 books.

Table of Contents

1. Introductory Remarks. Section I: Tumor Syndromes Affecting the Brain, Head, and Lungs. 2. Aicardi syndrome and Klinefelter syndrome. 3. BAP1 Tumor predisposition syndrome. 4. Congenital central hypoventilation syndrome. 5. Familial neuroblastoma. 6. Pleuropulmonary blastoma. 7. Retinoblastoma. 8. Rhabdoid tumor predisposition syndrome. 9. Rubinstein-Taybi syndrome. 10. Schinzel-Giedion syndrome. 11. Schwannomatosis. 12. Von Hippel-Lindau syndrome. Section II: Tumor Syndromes Affecting the Digestive System. 13. Alagille syndrome. 14. Constitutional mismatch repair deficiency syndrome. 15. Cronkhite-Canada syndrome. 16. Familial adenomatous polyposis. 17. Familial gastrointestinal stromal tumor. 18. Hereditary diffuse gastric cancer. 19. Juvenile polyposis syndrome. 20. Lynch syndrome. 21. MUTYH-associated polyposis. 22. Peutz-Jeghers syndrome. 23. Serrated polyposis syndrome. 24. Tylosis with esophageal cancer. Section III: Tumor Syndromes Affecting the Urogenitory System. 25. Bardet-Biedl synndrome. 26. Birt-Hogg-Dubé syndrome. 27. Bohring-Opitz syndrome. 28. Familial testicular germ cell tumor. 29. Familial Wilms tumor and related syndromes. 30. Hereditary breast cancer and ovarian cancer. 31. Hereditary leiomyomatosis and renal cell cancer. 32. Hereditary papillary renal cell cancer. 33. Hereditary prostate cancer. 34. Microphthalmia-associated transcription family translocation renal cell cancer. 35. Mulibrey nanism. Section IV: Tumor Syndromes Affecting the Skin, Soft Tissue, and Bone. 36. Brooke-Spiegler syndrome. 37. Currarino syndrome. 38. Cutaneous malignant melanoma. 39. Familial atypical multiple mole melanoma syndrome. 40. Familial chordoma. 41. Hereditary multiple osteochondromas. 42. Karatitis-Ichthyosis-Deafness syndrome. 43. Li-Fraumeni syndrome. 44. McCune-Albright syndrome. 45. Milroy disease. 46. Mosaic variegated aneuploidy syndrome. 47. Roberts syndrome. 48. Rothmund-Thompson syndrome. 49. Werner syndrome. 50. Xeroderma pigmentosum. Section V: Tumor Syndromes Affecting the Endocrine System. 51. Carney complex. 52. Congenital adrenal hyperplasia. 53. Familial hyperparathyroidism. 54. Familial isolated pituitary adenoma. 55. Familial non-medullary thyroid carcinoma. 56. Familial pancreatic cancer. 57. Hereditary pancreatitis. 58. Hereditary pheochromocytoma and paraganglioma syndrome. 59. Mahvash disease. 59. Multiple endocrine neoplasia. 60. Pendred syndrome. Section VI: Tumor Syndromes Affecting the Hematopoietic and Lymphoreticular Systems. 62. Ataxia-telangiectasia syndrome. 63. Autoimmune lymphoproliferative syndrome. 64. Bloom syndrome. 65. Chediak-Higashi syndrome. 66. Congenital amegakaryocytic thrombocytopenia. 67. Diamond-Blackfan anemia. 68. Down syndrome. 69. Dyskeratosis congenita. 70. Familial acute myeloid leukemia. 71. Familial monosomy 7 syndrome. 72. Familial multiple myeloma. 73. Fanconi anemia. 74. GATA2 Deficiency. 75. LPD Associated with Epstein-Barr virus infection. 76. Nijmegen breakage syndrome. 77. Severe congenital neutropenia. 78. Shwachman-Diamond syndrome. 79. Sjögren syndrome. 80. SRP72-Associated bone marrow failure syndrome. 81. Thrombocytopenia-absent radius. 82. Waldenström macroglobulinemia. Section VII: Overgrowth Syndromes, PTENopathies, and RASopathies. 84. Bannayan-Riley-Ruvalcaba syndrome. 85. Basal cell nevus syndrome. 86. Beckwith-Wiedemann syndrome. 87. CBL Syndrome. 88. CLOVES Syndrome. 89. Costello syndrome. 90. Cowden syndrome. 91. Klippel-Trenaunay syndrome. 92. Neurofibromatosis typese 1 and 2. 93. Noonan syndrome. 94. Perlman syndrome. 95. Proteus syndrome. 96. Schimmelpennning-Feuerstein-Mims syndrome. 97. Simpson-Golabi-Behmel syndrome. 98. Sotos syndrome. 99. Tuberous sclerosis complex. 100. Weaver syndrome.

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Biography

Dongyou Liu, PhD, has worked at several research and clinical laboratories in Australia and the United States for the past three decades, with a focus on molecular characterization of microbial pathogens and detection of human genetic disorders and tumors/cancers. He is the primary author of more than 50 original research and review articles in various peer-reviewed international journals, the contributor of 197 book chapters, and the editor of more than 10 books.