7th Edition

Hayes' Principles and Methods of Toxicology

    2140 Pages 496 B/W Illustrations
    by CRC Press

    Hayes’ Principles and Methods of Toxicology has long been established as a reliable and informative reference for the concepts, methodologies, and assessments integral to toxicology. The new edition contains updated and new chapters with the addition of new authors while maintaining the same high standards that have made this book a benchmark resource in the field.

    Key Features:

    • The comprehensive yet concise coverage of various aspects of fundamental and applied toxicology makes this book a valuable resource for educators, students, and professionals.
    • Questions provided at the end of each chapter allow readers to test their knowledge and understanding of the material covered.
    • All chapters have been updated and over 60 new authors have been added to reflect the dynamic nature of toxicological sciences
    • New topics in this edition include Safety Assessment of Cosmetics and Personal Care Products, The Importance of the Dose/Rate Response, Novel Approaches and Alternative Models, Epigenetic Toxicology, and an Expanded Glossary.  

    The volume is divided into 4 major sections, addressing fundamental principles of toxicology (Section I. "Principles of Toxicology"), major classes of established chemical hazards (Section II. "Agents"), current methods used for the assessment of various endpoints indicative of chemical toxicity (Section III. "Methods"), as well as toxicology of specific target systems and organs (Section IV. "Organ- and System-Specific Toxicology").

    This volume will be a valuable tool for the audience that wishes to broaden their understanding of hazards and mechanisms of toxicity and to stay on top of the emerging methods and concepts of the rapidly advancing field of toxicology and risk assessment.

    SECTION I    Principles of Toxicology

    Chapter 1    History, Understanding and a Possible Future of Toxicology. Harming and Helping through Time.

    Richard W. Lane with revisions and a new section by Anthony D. Dayan

    Chapter 2    Use of Toxicology in the Regulatory Process

    Robyn L. Prueitt, Barbara D. Beck, and Edward J. Calabrese

    Chapter 3    The Dose–Response: A Fundamental Concept in Toxicology

    Edward J. Calabrese

    Chapter 4    Metabolism: A Determinant of Toxicity

    Tao Wang and Richard Zang

    Chapter 5    Toxicokinetics

    Leanne L. Bedard

    Chapter 6    Physiologically Based Pharmacokinetic and Toxicokinetic Models

    Harvey J. Clewell III, Rebecca A. Clewell, and Melvin E. Andersen

    Chapter 7    Toxicopanomics: Applications of Genomics, Transcriptomics,
    Proteomics, Metabolomics and Lipidomics in Predictive Mechanistic Toxicology

    Mohamed-Amin Choukrallah, Marja Talikka, Stephanie Boue, Philippe Alexandre Guy, Aditya Reddy Kolli, Sandro Steiner, David Bovard, Diego Marescotti, Oksana Lavrynenko, Catherine Nury, James N. Battey, Bjorn Titz, Ulrike Kogel, Alain Sewer, Nicolas Sierro, Florian Martin, Nikolai V. Ivanov, Manuel C. Peitsch, and Julia Hoeng

    Chapter 8     Toxicologic Assessment of Pharmaceutical, Medical Device and Biotechnology Products

    Michael A. Dorato, Caitlin J. Murphy, J. Scott Daniels, Erin M. Quist, and C. Steven Godin

    Chapter 9    Statistics and Experimental Design for Toxicologists

    Shayne C. Gad

    Chapter 10  The Practice of Exposure Assessment

    Dennis J. Paustenbach, Amy K. Madl, and Andrey Massarsky

    Chapter 11  Epidemiology for Toxicologists

    Geary W. Olsen, Robert R. Roy, Sarah E. Kleinschmidt, and Ralph R. Cook

    Chapter 12  Pathology Principles and Practices for Toxicity Studies

    Brad Bolon, Tara Arndt, Adam Aulbach, and Kenneth A. Schafer

    Chapter 13  Chemical Toxicology Information Resources

    Stephanie Holmgren, Jacqueline Patterson, Kristina Thayer, Philip Wexler, and Antony J. Williams

    SECTION II    Agents

    Chapter 14  Food Safety and Foodborne Toxicants

    Fleur De Mooij, Yu Janet Zang, Amy L. Roe, and Angelika Tritscher

    Chapter 15  Plant and Animal Toxins

    Kevin D. Welch, Glenn F. King, Julian White, Leanne A. Pearson, Brett A. Neilan, and Daniel Cook

    Chapter 16  Safety Assessment of Cosmetics and Personal Care Products

    Christina Hickey, Siti Amelia Juraimi, Lauren Hutchison, Anne Marie Api, and Benjamin P.C. Smith

    Chapter 17  Solvents and Industrial Hygiene

    John E. Snawder

    Chapter 18  Crop Protection Chemicals: Mechanism of Action and Hazard Profiles

    James Bus

    Chapter 19  Metals

    Paul B. Tchounwou, Joseph R. Landolph, Jr., and Janis E. Hulla

    Chapter 20  Radiation Toxicity

    Roger O. McClellan

    SECTION III    Methods

    Chapter 21  The Humane Care and Use of Laboratory Animals in Toxicology Research

    Michael J. Caruso, Tyler C. Plachta, Christopher N. Papagiannis, Zac Lloyd, Dale M. Cooper, and David G. Serota

    Chapter 22  Novel Approaches and Alternative Models. Validation and Regulatory Acceptance of Toxicological Testing Methods and Strategies

    Nicole Kleinstreuer and David Allen

    Chapter 23  Modern Instrumental Methods for Studying Mechanisms of Toxicology

    W.M. Coleman, III, Serban C. Moldoveanu, Mehdi Ashraf-Khorassini, and Francis L. Martin

    Chapter 24  Acute Toxicity and Eye Irritancy

    Saura C. Sahu and A. Wallace Hayes

    Chapter 25  Short-Term, Subchronic, and Chronic Toxicology Studies

    Daniel T. Wilson, Jerry F. Hardisty, Torrie A. Crabbs, and Shannon M. Wallace

    Chapter 26  Genetic and Epigenetic Toxicology

    Leslie Recio and Tetyana Kobets

    Chapter 27  Carcinogenicity Bioassays and Related Assays; Human Relevance

    Gary M. Williams, Tetyana Kobets, Michael J. Iatropoulos, Thomas Nolte, and Esther Vock

    Chapter 28  Assessment of Behavioral Toxicity

    Deborah A. Cory-Slechta and Marissa Sobolewski

    SECTION IV    Organ- and System-Specific Toxicology

    Chapter 29  Dermatotoxicology

    Benjamin B. Hayes and Howard J. Maibach

    Chapter 30  Inhalation Toxicology

    John J. Godleski, Sandra A. McDonald, and Lester Kobzik

    Chapter 31  Gastrointestinal Toxicology

    Peter Pressman, Roger Clemens, and Robert W. Kapp, Jr.

    Chapter 32  Hepatotoxicology

    Maksat Babayev, Luma Melo, and James Klaunig

    Chapter 33  Principles and Methods for Renal Toxicology

    Jennifer G. Schnellmann and Rick G. Schnellmann

    Chapter 34  Cardiovascular Toxicology Methods

    Barry Bleske and Matthew J. Campen

    Chapter 35  Neurotoxicology

    Anke M. Tukker, Aaron B. Bowman, Lucio G. Costa, and Michael Aschner

    Chapter 36  Toxicology of the Endocrine System

    Carr J. Smith, Thomas A. Perfetti, and Judy A. King

    Chapter 37  Assessment of Male Reproductive Toxicity

    Natasha R. Catlin, Jon C. Cook, and Gregg D. Cappon

    Chapter 38  Female Reproductive and Developmental Toxicology

    Stephen B. Harris, Kary E. Thompson, Pragati S. Coder, Eve Mylchreest, Amy Lavin Williams, and John M. DeSesso

    Chapter 39  Immunotoxicology. The Immune System Response to Toxic Insult

    Florence G. Burleson, Stefanie C.M. Burleson, Gary R. Burleson, and Victor J. Johnson


    Dr. A. Wallace Hayes, a toxicologist with experience in industry and academics, has held professorships at the University of Alabama, University of Mississippi Medical Center, Wake Forest University School of Medicine, and Visiting Scientist at Harvard T. H. Chan School of Public Health and is currently an adjunct professor at the University of South Florida College of Public Health and Michigan State University Institute for Integrative Toxicology. He has 365 plus peer-reviewed publications. He is the editor for the Americas, Human and Experimental Toxicology, the editor-in-chief for Cutaneous and Ocular Toxicology, Toxicology Research and Application, and co-editor of the Target Organ Toxicity Book Series. He is the co-author of the Loomis’ Essentials of Toxicology. Dr. Hayes is a past Secretary-General of IUTOX (two terms), past treasurer of the American Board of Toxicology, past president of the American College of Toxicology, the Toxicology Education Foundation, the Academy of Toxicological Sciences, and the Toxicology Forum, and past councilor of the Society of Toxicology. Dr. Hayes is a diplomate of the American Board of Toxicology, the Academy of Toxicological Sciences, the American Board of Forensic Medicine, and the American Board of Forensic Examiners. He is a Fellow of the Academy of Toxicological Sciences, the Royal Society of Biology (UK), the Royal Society of Medicine (UK), the American College of Forensic Examiners Institute, and the American College of Nutrition. Dr. Hayes is a registered toxicologist in the European Union and a certified nutrition specialist (food safety). Dr. Hayes was honored by the Society of Toxicology in 2006 with the Society's Merit Award, by the Mid-Atlantic Society of Toxicology with its Ambassador Award in 2012, by the American College of Toxicology in 2012 with its Distinguished Scientist Award, by the International Dose-Response Society in 2013 with its Outstanding Leadership Award, and by The American Academy of Toxicology with its Mildred S. Christian Career Achievement Award in 2021. Dr. Hayes was named a Distinguished Fellow by the American College of Toxicology in 2013 and a Fellow by the American Association for the Advancement of Science in 2014.

    Dr. Tetyana Kobets is an Assistant Professor of Pathology, Microbiology, and Immunology at the New York Medical College (NYMC), Valhalla, NY. She conducts research on the development of alternative to animal models for the assessment of genotoxic potential and other hazardous effects of environmental chemicals. Her research interests include environmental and molecular toxicology as well as molecular biology of cancer, including epigenetic and genomic mechanisms of chemical carcinogenesis. In addition to her research work, she is actively involved in teaching pathology to medical and graduate students at NYMC. Dr. Kobets received her MD degree from the Ivano-Frankivsk National Medical University in Ukraine in 2010 and MS in Public Health from the Department of Environmental Sciences and Engineering at the University of North Carolina at Chapel Hill in 2013. Her Postdoctoral Fellowship was conducted in the Division of Biochemical Toxicology at the National Center for Toxicological Research (NCTR), US FDA, in Arkansas. She is a member of several professional societies, including the Society of Toxicology (SOT), Genetic Toxicology Association (GTA), Toxicology Forum and American College of Toxicology (ACT). She serves as an Associate Editor of Toxicology Research and Application.