Headache and Sleep Exploring the Intersection with Neurodegenerative Disorders

Chapter 1 Types and Classifications of Headaches İrem YILDIRIM, Aynur ÖZGE Chapter 2 Current Explanation for Trigeminovascular System and Central Sensitization Müge YEMİŞÇİ , Talha Berk BOLU, Hülya KARATAŞ KURŞUN Chapter 3 Impact of Headaches on Sleep Architecture Tuba CERRAHOĞLU ŞİRİN Chapter 4 Neurobiological Mechanisms of Sleep Regulation Mona HUSSAIN Chapter 5 Overview of Insomnia, Sleep Apnea, and Circadian Rhythm Disorders Rehab MAGDY, Güldeniz ÇETİN ERCİ Chapter 6 Impact of Comorbidities on Headaches and Sleep Disorders Berin GÜLATAR TÜRKOĞLU , Buse Çağla ARI Chapter 7 Mutual Influence of Sleep Disorders and Headache in Childhood Zeynep Ece TOKSOY, İbrahim ADAK Chapter 8 Current Genetic Associations with Clock Genes and Covariates Information Classification: General Giacomo RACIOPPI, Alessandra VOCI, Romina MOAVERO, Laura PAPETTI, Massimiliano VALERIANI Chapter 9 Potential Role of Frontostriatal Circuit Demet AYGÜN ÜSTEL, Hamit GENÇ Chapter 10 Potential Role of Epigenetic Mechanisms on the Headache-Sleep Disorders Association Turan POYRAZ, Gökhan GÜREL, Vincenzo GUIDETTI Chapter 11 Hallmarks of Neurodegenerative Disorders Hindol CHAKRABORTY Chapter 12 Common Sleep and Pain-Related Symptoms in Neurodegeneration Berkant Anıl ÖZÇELİK, Hatice ÇETİN Chapter 13 Mechanisms Linking Neurodegeneration to Sleep and Headache Pathologies Yeşim KAYA, Ağıt ÇETİNKAYA. Kübra HACIBEYOĞLU Chapter 14 How Sleep Modulates Headache Frequency and Severity Parisa GAZERANI Chapter 15 Headache Disorders as Precursors to Sleep Dysregulation Ayşenur ŞAHİN, Pınar YALINAY DİKMEN Chapter 16 Shared Pathways in Headache and Sleep Disorders Vildan ALTUNAYOĞLU ÇAKMAK, Sibel K.VELİOĞLU Chapter 17 REM Sleep Behavior Disorder and Restless Legs Syndrome in Alpha-Synucleinopathies Pelin YENİLMEZ YEŞİLDAŞ, İnci MÜLKEM ŞİMŞEK Chapter 18 Information Classification: General Sleep Disorders in Dementia Arzu ALDEMİR, Derya BAYRAK Chapter 19 Circadian Disruption in Huntington Disease and Prion Diseases Gülcan GÖÇMEZ YILMAZ , Tuba AKINCI Chapter 20 Crossing Pathways Between Sleep Disorders and Neurodegenerative Disorders Fatma Gülhan ŞAHBAZ, Esra DEMİR ÜNAL Chapter 21 Bidirectional Links Between Insomnia and Neurodegeneration Nur TÜRKMEN, Gizem GÜRSOY Chapter 22 Role of Neuroinflammation and Glial Activation Can ULUTAŞ, Rahşan KARACI Chapter 23 Dopaminergic, Serotonergic, and Orexinergic Pathways Esra KOCHAN KIZILKILIC, Esma KOBAK TUR Chapter 24 Mitochondrial Dysfunction and Oxidative Stress Nermin TEPE, Tuba ERDOĞAN SOYUKIBAR Chapter 25 Impact of Melatonin on Pain, Sleep and Neurodegeneration Serhat AKIN, Çağla ŞİŞMAN Chapter 26 Tools for Evaluating Sleep-Headache Interactions Mona NADA Chapter 27 Information Classification: General Biomarkers in Neurodegeneration: CSF, Imaging and Polysomnography Ozan DÖRTKOL, Arife Çimen ATALAR Chapter 28 Differential Diagnosis: Is it a Primary Disorder or Neurodegeneration? Burak YILDIZ, Ahmet EVLİCE Chapter 29 Pharmacological Interventions: Melatonin, Antiseizures, and CGRP Antagonists Nesrin ERGİN Chapter 30 Non-Pharmacological Approaches: CBT, Light Therapy, and Neurostimulation Tuba TANYEL SARAÇOĞLU, Derya ULUDÜZ Chapter 31 Challenges in the Treatment of Comorbid Conditions Zeynep SELCAN ŞANLI, Wael MOHAMED Chapter 32 Sleep Hygiene and Dietary Modifications Mansoureh TOGHA, Soodeh RAZEGHI Chapter 33 Exercise, Stress Management and Cognitive Training Merve CEREN AKGÖR, Arão Belitardo de OLIVEIRA Chapter 34 Challenges and Opportunities for Global Sleep Medicine Francis FEZEU Chapter 35 Case Studies and Clinical Vignettes: Alzheimer’s Disease with Chronic Migraine and Insomnia Zeynep ZİROĞLU, Esra ACIMAN DEMİREL Information Classification: General Chapter 36 Case Studies and Clinical Vignettes: Parkinson’s Disease with REM Sleep Behavior Disorder and Tension-Type Headache Aygül GÜNEŞ, Onur Serdar GENÇLER Chapter 37 Case Studies and Clinical Vignettes: Sleep Apnea and Chronic Migraine with and without Medication-Overuse Headache Michelle BRAVO, Angeliki VGONTZAS, Alexandra COCORES, Alberto RAMOS, Teshamae S. MONTEITH Chapter 38 Advances in Diagnostic Discovery: Wearable Technology Sümeyye Yasemin ÇALLI, Yağmur Sever FİDAN, Füsun MAYDA DOMAÇ Chapter 39 Emergent Therapies Targeting Shared Pathways Şennur DELİBAŞ KATI Chapter 40 Integrating Precision Medicine into Clinical Practice Burcu KARPUZ SEREN

Biography

Füsun Mayda Domaç, MD, Msc Information Classification: General Professor Füsun Mayda Domaç earned her Medical Degree from Istanbul University, Cerrahpasa Medical Faculty,Türkiye. She is a neurologist and has a master degree of clinical neurophysiology from Marmara University. Dr Domaç is the founding and current Chief Director of both Neurology Department and Sleep Medicine Center at University of Health Sciences Erenköy Mental Health and Nervous Diseases Training and Research Hospital, İstanbul,Türkiye. She is the president of ethical committee of the same institution and also a current board member of Turkish Neurological Society. Dr Domaç has over 130 peer-reviewed publications to her name, has been an author of 30 book chapters and an editor of 6 multi-author scientific books. Being mainly specialized and having extensive experience in sleep disorders and headache, she is advanced in the diagnoses, treatment, management and training of both disorders. She is pioneering efforts in drawing attention to the interactions between headaches and sleep disorders and carries out social responsibility projects to increase public awareness. Wael Mohamed, MSc, MD, PhD, FAAS Dr Mohamed is a Physician Neuroscientist. He earned his Medical Degree from Menoufia Medical School, Egypt, and his Doctorate Degree from Pennsylvania State University, USA. After finishing his training in the Neurosurgery Department, he started his career as a clinical pharmacologist with Information Classification: General psychopharmacology as a subspecialty. Currently, he is a professor in IIUM, Malaysia. His translational brain research targets the investigation and development of novel treatment for Alzheimer’s Disease and Parkinson’s Disease using zebrafish animal models. He is the founder and chair of the AfrAbia Parkinson’s Disease Genetic Consortium (AA-PD-GC), which is supported by GP2 and the Michael J. Fox Foundation to advance PD genotyping efforts across AfrAbia countries. A prolific author and editor, Dr. Mohamed has published over 150 peer-reviewed articles and led 16 influential academic books making him a global leader in neuropharmacology and clinical brain science. Aynur Özge, MD Professor Aynur Özge has extensive experience in international neurological research, medical education, and the leadership of multi-author scientific book projects. With an H-index of 43 and over 230 international publications to her name, she has been a driving force in global collaborations advancing the diagnosis, management, and treatment of complex neurological conditions. Her work is notably distinguished by the founding of the first and only comprehensive 5-step care model for Alzheimer’s disease in Türkiye, showcasing her ability to translate high-level specialist knowledge into practical, community-based care frameworks. Her current academic and clinical work emphasizes integrating specialized Information Classification: General neurology and algology expertise into accessible, clinically usable models for broader healthcare applications. By bridging the gap between advanced medical research and primary care practices, she continues to advocate for patient safety, rational treatment, and the preservation of cognitive health across populations.