500 Pages
    by CRC Press

    500 Pages
    by CRC Press

    Heart Failure, Second Edition has been updated to provide the latest advancements in heart failure research. Supplemented by more than 200 high-quality figures and illustrations, the book helps cardiologists and emergency care physicians quickly and accurately identify the cause and severity of a patient’s cardiac impairment.

    New topics in this edition include:

    • Developments in mechanical and pharmacologic treatments

    • Discoveries in developmental biology

    • Up-and-coming imaging modalities

    • Surgical options for mechanical circulatory support and cardiac transplantation

    • Pharmacogenomics and gene-based and cell-based therapies

    • Gene expression/recurrence in heart failure

    • Changes in metabolic substrate utilization and pathways

    Part 1: Cellular and Molecular Basis for Heart Failure
    A Brief Primer on the Development of the Heart
    Serge Gregoire and Sean Wu
    The Genetics of Dilated and Hypertrophic Cardiomyopathies
    Calum Macrae
    Molecular Signaling Networks Underlying Cardiac Hypertrophy and Failure
    Gerald W Dorn II MD
    Excitation-Contraction Coupling in the Normal and Failing Heart
    Mattew Coggins, Bernhard Haring, Federica del Monte
    Myocardial energetics and cellular metabolism in the failing heart
    Joanne S. Ingwall
    Animal Models of Heart Failure
    William Carlson

    Part II: Pathophysiology of Heart Failure
    Ventricular Remodeling and Secondary Valvular Dysfunction in Heart Failure Progression
    Kibar Yared, Judy Hung
    Neurohormonal and Cytokine Activation in Heart Failure
    Dennis McNamara
    Cardiomyopathies in the Adult
    Richard Rodeheffer
    Water and Salt: the cardiorenal syndrome
    Maria Rosa Costanzo

    Part III: The Demographics, Diagnosis and Monitoring of Heart Failure:
    The Clinical Syndrome of Heart Failure
    Thomas DiSalvo, Jordon Shin
    Clinical Profiles and Bedside Assessment
    Lynne Warner Stevenson
    Prognosis in Heart Failure
    J. Susie Woo, Wayne C. Levy,
    Biomarkers in Heart Failure
    Ravi V. Shah, MD and Thomas J. Wang
    Noninvasive Imaging Modalities for the Evaluation of Heart Failure
    Kimberly A. Parks and Malissa J. Wood
    Role of Invasive Monitoring in Heart Failure: Pulmonary Artery Catheters in the Post-ESCAPE Era
    W. H. Wilson Tang, Gary S. Francis

    Part IV: The Medical Treatment of Clinical Heart Failure
    Conventional Therapy of Chronic Heart Failure: Diuretics, Vasodilators, and Digoxin
    G. William Dec, MD
    Conventional Therapy of Chronic Heart


        Marc Semigran is Associate Professor of Medicine, Harvard Medical School; Director, Heart Failure and Transplant Service, Massachusetts General Hospital; Attending Physician, Cardiac Catheterization, Laboratory, Medical Services, Coronary Care Unit, and Cardiology Consultation Service, Massachusetts General Hospital, Boston, Massachusetts, USA. He is a member of fellow of several organizations, including the American College of Physicians, the American College of Cardiology, the American Heart Association, the International Society of Heart and Lung Transplantation, and the Working Group of Transplant Cardiologists.

        Dr. Semigran is a reviewer for several publications, including the American Journal of Cardiology, Anesthesia, Journal of the American College of Cardiology, New England Journal of Medicine, Journal of the American College of Cardiology, Arthritis and Rheumatism, Circulation, and the Journal of Heart and Lung Transplantation. He also contributed to the first edition of Heart Failure.

        Jordan T. Shin is Professor of Medicine, Harvard Medical School and Assistant Physician, Massachusetts General Hospital, Boston, Massachusetts, USA. He is a member of numerous organizations, including the Massachusetts Medical Society, the American Medical Association, American College of Cardiology, the American Association for the Advancement of Science, Member, the American Heart Association, and the Heart Failure Society of America.