1st Edition

Heat Shock Proteins in Myocardial Protection

By Rakesh C. Kukreja Copyright 2000
115 Pages 40 B/W Illustrations
by CRC Press

115 Pages
by CRC Press

Myocardial ischemic syndromes pose a major medical problem and a significant economic health care concern. Reperfusion, although used in the clinical arena as essential to the survival of acutely ischemic heart muscle carries with it the risk of "reperfusion injury". Therefore the salvage of additional myocardium is highly desirable. Over a decade ago, it was shown that whole body heat shock... Read more
1. Stress Proteins in Myocardial Protection 2. Heat Stress Proteins: A Possible Route to Myocardial Protection 3. Cardioprotection by Stress Proteins 4. Role of H eat Shock Proteins, Protein Kinase C and ATP -Sensitive Potassium Channel in Delayed Myocardial Protection .5. Hsp70 and Ischemia Tolerance in the Compromised Heart. 6 . Hsp72 in the Regulation of TNF-?? Production: Mechanistic Implication of Protection Against Postischemic Myocardial Dysfunction 7. Preconditioning of Cardiac Myocytes 8. Antisense, Heat Shock Proteins and the Heart 9. Stress Proteins in Myocardial Protection: Culture Shock Protein, Hem e Oxygenase- 1 (Hsp 3 2 ), Induced by Sublethal Stresses Protects the Heart Against Oxidative Stress 10. Physiological Role of Heat Shock Protein 27 11. Ischemia/Reperfusion Injury and Heat Shock Proteins

Biography

Kukreja, Rakesh C.