1st Edition

Hematopoiesis Biochemical, Cellular, Molecular, and Genomic Perspectives

Edited By Ravi Kumar Gutti Copyright 2024
    318 Pages 19 Color & 4 B/W Illustrations
    by Apple Academic Press

    318 Pages 19 Color & 4 B/W Illustrations
    by Apple Academic Press

    This new volume discusses the widespread concerns of hematopoietic challenges in different and emerging ways. With chapters written by faculty and researchers from prestigious institutions working directly in hematopoiesis and advanced areas of biology, the volume offers a comprehensive overview of the regulation of blood cell development, epigenetic mechanisms, and regulatory non-coding RNAs. It presents concepts related to regulation of hematopoietic stem cell development, as well as survival, proliferation, and differentiation. It also discusses the microenvironmental niche where stem cells exist and develop into distinct blood cell types. A model system used to study non-coding RNA functions along with transformation of normal cells into cancer cell is elaborated on as well.

    Key features of the book:

    • Details how to utilize the available investigative tools and techniques to isolate and study single blood cells in different model systems
    • Discusses the epigenetics of hematopoiesis
    • Considers the clinical outcomes of defective hematopoiesis
    • Describes hematopoiesis and cancer stem cells
    • Looks at hematopoiesis in relation to specific diseases, such as minimal residual disease (MRD) and leukemia

    This book provides valuable information related to developments in hematopoiesis that will be helpful for understanding the basics of hematopoiesis and the clinical treatment of blood diseases. Hematopoiesis: Biochemical, Cellular, Molecular, and Genomic Perspectives will be valuable to clinicians, medical school students, and researchers working in hematology.

    1. Unrevealing the Mechanism of Zebrafish Hematopoiesis: A Novel Approach

    Aparajita Chakraborty

    2. Investigative Tools to Study Blood Cells: Focus on Single Cell Isolation and Analysis

    Dushyant Kumar Gautam, Anuradha Venkatakrishnan Chimata, Ravi Kumar Gutti, and Indira Paddibhatla

    3. Evaluation of Chitosan and Its Derivatives in Immunomodulating Blood Sentinel Cells

    Arun Kumar Subramani, Keyur Raval, and Ritu Raval

    4. Proteoglycans and Glycosaminoglycans Regulating Functions of the Hematopoietic Stem Cell Niche

    Samiksha Wasnik, Lakshmi Manasa Chaturvedula, and Chaturvedula Tripura

    5. Epigenetics of Hematopoiesis: Role of HATs and HDACs

    Arunasree M. Kalle and Debasmita Naik

    6. Systems Biology Approaches Toward Understanding Human Long Non-Coding RNA Hematopoietic Cells

    Swati Dahariya, Sanjeev Raghuwanshi, and Ravi Kumar Gutti

    7. Clinical Outcomes of Defective Hematopoiesis

    Geeta Rai, Doli Das, Khushbu Priya, and Hiral Thacker

    8. Circulating Messengers of Blood and Their Clinical Applications

    Rasmita Samal and Anula Divyash Singh

    9. Hematopoiesis and Cancer Stem Cells: The Seed and the Soil Crosstalk

    Akhilesh Prajapati

    10. lncRNAs in Types of Leukaemia

    Swati Dahariya, Aditya Velidandi, Dushyant Kumar Gautam, Ravi Kumar Gutti and Indira Paddibhatla

    11. Minimal Residual Disease (MRD) as a Prognostic Factor in Acute Myeloid Leukaemia

    Anpreet Choudhary, Rekha Sharma, Satti Vishnupriya, Rajender Rao K, Raghunath Manchala, Suvir Singh, Obul Reddy Bandapalli , Prashant Suravajhala, Raghunadharao Digumarthi, and Sugunakar Vuree


    Ravi Kumar Gutti, PhD,  is Professor in the Department of Biochemistry of the School of Life Sciences at the University of Hyderabad, India. He has extensive research and teaching experience from Harvard Medical School (USA), National Institutes of Health (USA), Moffitt Cancer and Research Centre (USA), and RWTH Aachen (Germany). His research primarily focuses on understanding the molecular mechanisms in low platelet diseases and is well funded by several grants from the Government of India and other organizations. He has received awards and recognition from several prominent national and international organizations, including a Chancellor's Award from the University of Hyderabad for making significant contributions to teaching and research. Dr. Gutti has authored several publications in reputed international journals and has presented his research at international scientific meetings.

    "Provid[es] an accurate overview of the functional importance of hematopoiesis from different perspectives and the surrounding molecular mechanisms that influence the process of hematopoiesis in one way or another. Extremely pertinent and up-to-date information . . . Highly recommended . . . Sheds light on different factors that indulge and regulate the hematopoietic events. The uniqueness of this book encompasses the myriad of information on the biology of normal and aberrant hematopoiesis, epigenetic factors, and on the research tools to assist in the deeper study of aspects relating to the status of blood cells in cancerous scenario. . . . Some specifics of leukemia/lymphoma governed by various non-conventional molecules are also part of this book."

    From the Foreword by Prof. Dr. Natália Cruz-Martins, PhD, Cooperativa de Ensino Superior Politécnico e Universitário (CESPU); Faculdade de Medicina, Universidade do Porto (FMUP), Porto, Portugal